Keap1-Nrf2 (Danio rerio)

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1S-PT-PPhase II enzymesARES-PT-PNucleusCCAAT/XRELOC562176nfe2l2LOC100149498nfe2l2gclmSulforaphaneLOC561737hmox1GSTA2zgc:63976cebpbnqo1Curcumin6-HITCCaffeic acid phenethyl esterMAFcebpbnfe2l2gclckeap1bkeap1bzgc:172209



This pathway was inferred from Homo sapiens pathway WP3(r29720) with a 88% conversion rate.

Quality Tags

Ontology Terms



  1. Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC


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106069view11:58, 16 August 2019MaintBotHMDB identifier normalization
88687view15:49, 12 August 2016JmeliusOntology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
88686view15:49, 12 August 2016JmeliusOntology Term : 'oxidative stress response pathway' added !
71507view19:21, 17 October 2013MaintBotAutomated update of data sources
68628view04:40, 6 July 2013MaintBotUpdated to 2013 gpml schema
46422view20:47, 27 January 2012MaintBotAutomatic update of PubChem xrefs
40793view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
34183view21:22, 9 December 2009MaintBotAutomatic update of empty xrefs
31921view12:53, 14 August 2009MaintBotFixed group labels
31042view01:19, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
6-HITCMetaboliteFull name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
Caffeic acid phenethyl esterMetabolite
CurcuminMetaboliteHMDB0002269 (HMDB)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC561737GeneProduct561737 (Entrez Gene)
LOC562176GeneProduct562176 (Entrez Gene)
MAFGeneProduct114467 (Entrez Gene)
SulforaphaneMetaboliteHMDB0005792 (HMDB)
cebpbGeneProduct140814 (Entrez Gene)
gclcGeneProduct326857 (Entrez Gene)
gclmGeneProduct333974 (Entrez Gene)
hmox1GeneProduct791518 (Entrez Gene)
keap1bGeneProduct100003679 (Entrez Gene)
nfe2l2GeneProduct360149 (Entrez Gene)
nqo1GeneProduct322506 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:63976GeneProduct406647 (Entrez Gene)

Annotated Interactions

No annotated interactions
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