Estrogen Signaling (Danio rerio)

From WikiPathways

Jump to: navigation, search
Transcription Initiation Factors (TIFs)TIFsTFIIE+pActivationanti apoptosis+pRNA polymerase IITFIIATFIIBERE+pHistone Deacetylases (HDACs)TFIIDIKKsTFIIHTranslocationRNA Pol IIGene expression(anti apoptotic)MitochondrionHDACsNucleusInhibitionTATA Box bindingproteinGene expressionMAPKsTFIIFcrebbpbLOC792188si:ch211-194d6.2junzgc:110584LOC557486LOC792354taf7mnat1NFKBhdac8srcSIN3ercc2polr2jHDAC7Apolr2glhdac6Estradiolmapk14agtf2besr1gtf2h4LOC561737polr2ahdac1EstradiolSOShdac3BCL2GTF2F2gpercreb1esr1fostaf13si:dkey-94n12.3BRCA1esr1LOC100149268polr2etaf5LOC567895LOC100149273mapk1esr1gngt1LOC792258ilkGNB1Estradiolhdac4POLR2IEstradiolEstradiolesr1taf9ercc3EstradiolBCL2map2k1ccnhHDAC2ncor1ep300azgc:158799TAF12ikbkbLOC557353chukccnd1braftbpcdk7Estradiolzgc:92126RASgtf2h2esr1taf6esr1tbpikbkgGTF2H3grb2EstradiolLOC791979EstradiolPOLR2Kcreb1sp1gtf2e2NFKBesr1Cyclic AMPesr1zgc:110584


Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.


This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 81% conversion rate.

Quality Tags

Ontology Terms



  1. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  2. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC Scholia
  3. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia


View all...
106068view11:58, 16 August 2019MaintBotHMDB identifier normalization
88034view13:35, 25 July 2016SusanOntology Term : 'estrogen signaling pathway' added !
70181view01:26, 13 July 2013AlexanderPicoModified title
68629view04:41, 6 July 2013MaintBotUpdated to 2013 gpml schema
58786view22:45, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
46427view20:47, 27 January 2012MaintBotAutomatic update of PubChem xrefs
40795view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
34184view21:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32319view13:24, 15 August 2009MaintBotFixed text labels
31920view12:52, 14 August 2009MaintBotFixed group labels
31354view20:32, 13 August 2009MaintBotFixed text labels
31040view01:18, 30 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
BCL2GeneProduct570772 (Entrez Gene)
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
EstradiolMetaboliteHMDB0000151 (HMDB)
GNB1GeneProduct322104 (Entrez Gene)
GTF2F2GeneProduct415217 (Entrez Gene)
GTF2H3GeneProduct436837 (Entrez Gene)
HDAC2GeneProductHDAC2; histone deacetylase 2
HDAC7AGeneProductHDAC7A; histone deacetylase 7
LOC100149268GeneProduct100149268 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC557353GeneProduct557353 (Entrez Gene)
LOC557486GeneProduct557486 (Entrez Gene) HDAC5; histone deacetylase 5
LOC561737GeneProduct561737 (Entrez Gene)
LOC567895GeneProduct567895 (Entrez Gene)
LOC791979GeneProduct791979 (Entrez Gene)
LOC792188GeneProduct792188 (Entrez Gene)
LOC792258GeneProduct792258 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
TAF12GeneProduct386637 (Entrez Gene)
brafGeneProduct403065 (Entrez Gene)
ccnd1GeneProduct30222 (Entrez Gene)
ccnhGeneProduct541325 (Entrez Gene)
cdk7GeneProduct405897 (Entrez Gene)
chukGeneProductENSDARG00000011662 (Ensembl)
creb1GeneProduct573207 (Entrez Gene)
crebbpbGeneProduct503776 (Entrez Gene)
ep300aGeneProduct559273 (Entrez Gene)
ercc2GeneProduct393900 (Entrez Gene)
ercc3GeneProduct324323 (Entrez Gene)
esr1GeneProduct259252 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
gngt1GeneProduct335656 (Entrez Gene)
gperGeneProduct565271 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
gtf2bGeneProduct324823 (Entrez Gene)
gtf2e2GeneProduct334854 (Entrez Gene)
gtf2h2GeneProduct323239 (Entrez Gene)
gtf2h4GeneProduct334839 (Entrez Gene)
hdac1GeneProduct192302 (Entrez Gene) HDAC1; histone deacetylase 1
hdac3GeneProduct393965 (Entrez Gene) HDAC3; histone deacetylase 3
hdac4GeneProduct568877 (Entrez Gene) HDAC4; histone deacetylase 4
hdac6GeneProduct565482 (Entrez Gene) HDAC6; histone deacetylase 6
hdac8GeneProduct406740 (Entrez Gene) HDAC8; histone deacetylase
ikbkbGeneProductENSDARG00000079123 (Ensembl)
ikbkgGeneProductENSDARG00000017037 (Ensembl)
ilkGeneProduct393543 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
map2k1GeneProductENSDARG00000007825 (Ensembl)
mapk14aGeneProduct65237 (Entrez Gene)
mapk1GeneProductENSDARG00000027552 (Ensembl)
mnat1GeneProduct450080 (Entrez Gene)
ncor1GeneProduct393246 (Entrez Gene)
polr2aGeneProduct553347 (Entrez Gene)
polr2eGeneProduct445170 (Entrez Gene)
polr2glGeneProduct324088 (Entrez Gene)
polr2jGeneProduct554099 (Entrez Gene)
si:ch211-194d6.2GeneProduct567899 (Entrez Gene)
si:dkey-94n12.3GeneProduct562011 (Entrez Gene)
sp1GeneProduct324109 (Entrez Gene)
srcGeneProduct325084 (Entrez Gene)
taf13GeneProduct324153 (Entrez Gene)
taf5GeneProduct641491 (Entrez Gene)
taf6GeneProduct447818 (Entrez Gene)
taf7GeneProduct100002261 (Entrez Gene)
taf9GeneProduct321485 (Entrez Gene)
tbpGeneProduct368882 (Entrez Gene)
zgc:110584GeneProduct798997 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)
zgc:92126GeneProduct447857 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools