Wnt Signaling Pathway (Danio rerio)

From WikiPathways

Jump to: navigation, search
GlycosylationEndosomeDesumoylationGolgi apparatusENDMTDCY->PMDAcetylationMethylationSumoylationEnzyme ComplexCY->NUDephosphorylationUbiquitinationNUActivationNU->CYPlasma membraneAutophosphorylationProteolytic cleavageDeacetylationReceptorRecruitmentInhibitionPM->CYDPhosphorylationCY->PMMolecule in the pathwayDemethylationPalmitoylationCY->NUCYGO(Protein-protein interaction)Proteins in a complex interactionTranslocationERCY->NUPMReaction through unknowm mechanisms/moleculesCY->NUExtracellularAccession Number: NetPath_8; cellmap:8LigandDCY->PMDDControlNucleusDCytoplasmComplex formationGene SymbolDeubiquitinationDECEndoplasmic reticulumMolecular AssociationMitochondrionCY->PMCY->NUBTRCFZD9LOC560032CXXC4sb:cb458wnt1TCF4LOC449616UBL1FZD1wnt3lcamk2aruvbl1axin1pias4LRP6smad3bsall1awnt3dvl2LRP6sfrp2cdc2map3k7SOX1zgc:113045wnt1FHL2LOC556379FZD1wnt1WNT4csnk1a1CDH1APCaxin2LOC556379FZD4BTRCFZD8LOC792354fzd2lef1tbpwnt3lLOC560032crybb2fzd8cLOC100149273wnt5aAPCwnt7actnnb1APChipk2arrb1raf1APCSFRP1zgc:136929camk2d2ccnd1wnt1lrp5cmybprkcb1LOC100000823map3k7tfap2azgc:153713PIN1ctnnb1vangl2WNT4LOC100149498im:7163520lef1wu:fc75f05BRD7ankrd6gsk3bLOC100003514ck2bPAX2LOC559111wnt2bcsnk1dbdlg1ARRB2CTNNBIP1zgc:56064LOC565797csnk1daLOC560032FZD4wnt2baxin1FRAT1rac1LOC571171sox9aLOC561183mapk3zgc:172209FRAT2APCLOC792354dvl2dlg2CDC25Cdkk1ctbp2gsk3bwnt1LOC100149082ep300aSKP1Azgc:92241mapk1nkd1runx2ajunFZD7cul1aCAMK2Gctnnb1DAAM1zgc:65879LOC100151220tax1bp3SF1LOC793336cdc2nlk2ARRB2FZD1FZD1axin1JUPMAGI3LOC798222LOC571171


Description

Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NethPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP363(r28127) with a 70% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
86972view14:28, 15 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
79345view16:27, 21 March 2015Khanspersupdate
79344view16:26, 21 March 2015Khanspersupdate
79343view16:26, 21 March 2015KhanspersReverted to version '22:20, 1 March 2011' by Khanspers
68694view05:56, 6 July 2013MaintBotUpdated to 2013 gpml schema
40870view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
38721view19:34, 23 September 2010AlexanderPico
35034view09:18, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35026view09:15, 11 February 2010ThomasModified description
34250view21:44, 9 December 2009MaintBotAutomatic update of empty xrefs
31352view20:31, 13 August 2009MaintBotFixed text labels
31035view01:16, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APCGeneProduct386762 (Entrez Gene)
ARRB2GeneProduct
BRD7GeneProduct406675 (Entrez Gene)
BTRCGeneProduct
CAMK2GGeneProduct
CDC25CGeneProduct
CDH1GeneProduct114424 (Entrez Gene)
CTNNBIP1GeneProduct
CXXC4GeneProduct
DAAM1GeneProduct557451 (Entrez Gene)
FHL2GeneProduct
FRAT1GeneProduct
FRAT2GeneProduct
FZD1GeneProduct30365 (Entrez Gene)
FZD4GeneProduct30363 (Entrez Gene)
FZD7GeneProduct
FZD8GeneProduct
FZD9GeneProduct58023 (Entrez Gene)
JUPGeneProduct30415 (Entrez Gene)
LOC100000823GeneProduct100000823 (Entrez Gene)
LOC100003514GeneProduct100003514 (Entrez Gene)
LOC100149082GeneProduct100149082 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC100151220GeneProduct100151220 (Entrez Gene)
LOC449616GeneProduct449616 (Entrez Gene)
LOC556379GeneProduct556379 (Entrez Gene)
LOC559111GeneProduct559111 (Entrez Gene)
LOC560032GeneProduct560032 (Entrez Gene)
LOC561183GeneProduct561183 (Entrez Gene)
LOC565797GeneProduct565797 (Entrez Gene)
LOC571171GeneProduct571171 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
LOC793336GeneProduct793336 (Entrez Gene)
LOC798222GeneProduct798222 (Entrez Gene)
LRP6GeneProduct100003877 (Entrez Gene)
MAGI3GeneProduct
PAX2GeneProduct
PIN1GeneProduct393721 (Entrez Gene)
SF1GeneProduct572785 (Entrez Gene)
SFRP1GeneProduct
SKP1AGeneProduct
SOX1GeneProduct
TCF4GeneProduct
UBL1GeneProduct
WNT4GeneProduct
ankrd6GeneProduct378477 (Entrez Gene)
arrb1GeneProduct553266 (Entrez Gene)
axin1GeneProduct57931 (Entrez Gene)
axin2GeneProduct58080 (Entrez Gene)
camk2aGeneProduct550436 (Entrez Gene)
camk2d2GeneProduct436815 (Entrez Gene)
ccnd1GeneProduct30222 (Entrez Gene)
cdc2GeneProduct80973 (Entrez Gene)
ck2bGeneProduct30428 (Entrez Gene)
cmybGeneProduct30519 (Entrez Gene)
crybb2GeneProduct553182 (Entrez Gene)
csnk1a1GeneProduct192307 (Entrez Gene)
csnk1daGeneProduct322106 (Entrez Gene)
csnk1dbGeneProduct406533 (Entrez Gene)
ctbp2GeneProduct65230 (Entrez Gene)
ctnnb1GeneProduct30265 (Entrez Gene)
cul1aGeneProduct323883 (Entrez Gene)
dkk1GeneProduct30197 (Entrez Gene)
dlg1GeneProduct114446 (Entrez Gene)
dlg2GeneProduct497638 (Entrez Gene)
dvl2GeneProduct323630 (Entrez Gene)
ep300aGeneProduct559273 (Entrez Gene)
fzd2GeneProduct30370 (Entrez Gene)
fzd8cGeneProduct30364 (Entrez Gene)
gsk3bGeneProduct30654 (Entrez Gene)
hipk2GeneProduct557551 (Entrez Gene)
im:7163520GeneProduct556400 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
lef1GeneProduct30701 (Entrez Gene)
lrp5GeneProduct568518 (Entrez Gene)
map3k7GeneProduct553788 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
nkd1GeneProduct751108 (Entrez Gene)
nlk2GeneProduct563460 (Entrez Gene)
pias4GeneProduct406712 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
rac1GeneProduct327204 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
runx2aGeneProduct405784 (Entrez Gene)
ruvbl1GeneProduct317679 (Entrez Gene)
sall1aGeneProduct555721 (Entrez Gene)
sb:cb458GeneProduct368323 (Entrez Gene)
sfrp2GeneProduct566878 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
sox9aGeneProduct60641 (Entrez Gene)
tax1bp3GeneProduct406779 (Entrez Gene)
tbpGeneProduct368882 (Entrez Gene)
tfap2aGeneProduct140618 (Entrez Gene)
vangl2GeneProduct245949 (Entrez Gene)
wnt1GeneProduct30128 (Entrez Gene)
wnt2bGeneProduct359837 (Entrez Gene)
wnt3GeneProduct569420 (Entrez Gene)
wnt3lGeneProduct60632 (Entrez Gene)
wnt5aGeneProduct568191 (Entrez Gene)
wnt7aGeneProduct565714 (Entrez Gene)
wu:fc75f05GeneProduct562231 (Entrez Gene)
zgc:113045GeneProduct664768 (Entrez Gene)
zgc:136929GeneProduct678649 (Entrez Gene)
zgc:153713GeneProduct751630 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:56064GeneProduct393885 (Entrez Gene)
zgc:65879GeneProduct393533 (Entrez Gene)
zgc:92241GeneProduct445027 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools