EGFR1 Signaling Pathway (Danio rerio)

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1CYEndosomeNUCYCYPMPMCYGlycosylationNUCYInhibitionCYPMCYNucleusActivationCYCYControlENAcetylation(Protein-protein interaction)DPMCYMAERMALigandCYPalmitoylationCYPMDeacetylationNUCYGOCYAutophosphorylationPMNUAutodephosphorylationAccession Number : NetPath 4; cellmap:4MARecruitmentCYNUNUMANUPMNUPMCYPMMAPlasma membranePMEnzyme complexCytoplasmNUNUMACYPMMAPMNUCYCYCYPhosphorylationGene SymbolDCYCYMAMACYMACYEndoplasmic reticulumMACYProteolytic cleavageCYDephosphorylationGolgi apparatusMACYENCYDNUMANUPMProteins in a complex interactionECMolecule in the pathwayExtracellularPMNUNUMolecular associationMTMAUbiquitinationCYNUMAMitochondrionSumoylationReceptorCYNUPMCYPMMAMAPMDemethylationCYENNUCYDeubiquitinationMATranslocationCYMADesumoylationNUMAPMPMPMReaction through unknown mechanisms/moleculesNUMethylationCYPMPMMAzgc:92074LOC100149498ptpn6PTK6cebpbrps6ka3aprkczKRT17LOC568935tgif1LOC565173SH3KBP1wu:fb92a07raf1egfCH211-251J10.3LOC564517ELK4mapk3ptpn6smad3bSTAT2si:ch211-197i12.3zgc:92024hdac1HRASstat3LOC557176pik3cdmapk7pxnKRT8sh2d3caegfLOC100151336sh3gl2wu:fc83c01cblbcamk2aLOC793823spry2pak1zgc:172250pik3r3prkciSNRPD2SIN3Azgc:110206LOC558153stat1amapk1MYCsocs1PLSCR1appl2stat3stat3casp9LOC571965CEACAM1dnm2crkLOC562032pld2zgc:175192zgc:64130gab1LOC556726RAB5AHIST3H3LOC795505LOC100007590NDUFA13httptk2bbREPS2raf1LOC561737im:7150469hat1APPLjundLOC557123mta2LOC563639znf259sh2d3cadusp1zgc:162129YWHABdusp1egfratf1zgc:112145gab1crklPLEC1DOK2cebpaprkcb1si:dkey-217m5.1LOC567895znf259zgc:175192ptpn11LOC557201junsmad2rps6ka3bLOC558321zgc:158742MAP2K3ripk1lpik3r2ralbAPPLLOC563639LOC558321map3k3SNCAnrasNCK1GRB7plcg2LOC559119EEF1A1DDEF1ARF4STAT5BEEF1A1LOC564899PTPN12sh3gl2SOS1zgc:172209pbpspry2elf3si:dkeyp-192m14.7CH211-125M10.3CSKLOC792354cblstat1acav1kraszgc:172137SOCS3LOC100008005LOC100149671LOC560913map2k1map2k1KLF11FOXO1Awaslaegfrplcg1zgc:56041cx43si:ch211-240l19.1LOC562134cdc42lmapk1wu:fk86g11STAT5APLD1MAP3K14srcSTAT5Aplcg1EPN1PLD1rbb4lCBLCjak1wu:fc58a04LOC100149498egfrLOC100003514mapk14aegfLOC571285VAV2LOC795505APPLARF4jak2bLOC559524KRT18rps6ka3brac1zgc:153534FOXO1Agrb2smad3bplcg2sp1elf3tnip1stat1aegfrstxbp1ARF4stxbp1foszgc:76867STAT2LOC568321cav2VAV1rasa1pitpnacreb1CH211-67F24.8smad2zgc:77033appl2


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 76% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
68672view05:30, 6 July 2013MaintBotUpdated to 2013 gpml schema
67176view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
40845view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35723view23:30, 12 February 2010AlexanderPico
35433view11:29, 12 February 2010MichielAdded ref
34227view21:36, 9 December 2009MaintBotAutomatic update of empty xrefs
31033view01:15, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APPLGeneProduct
ARF4GeneProduct
CBLCGeneProduct
CEACAM1GeneProduct114465 (Entrez Gene)
CH211-125M10.3GeneProduct558144 (Entrez Gene)
CH211-251J10.3GeneProduct799483 (Entrez Gene)
CH211-67F24.8GeneProduct561670 (Entrez Gene)
CSKGeneProduct556454 (Entrez Gene)
DDEF1GeneProduct326709 (Entrez Gene)
DOK2GeneProduct
EEF1A1GeneProduct
ELK4GeneProduct30093 (Entrez Gene)
EPN1GeneProduct406671 (Entrez Gene)
FOXO1AGeneProduct768121 (Entrez Gene)
GRB7GeneProduct
HIST3H3GeneProduct
HRASGeneProduct550286 (Entrez Gene)