IL-2 Signaling Pathway (Danio rerio)

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Molecule in the pathwayDesumoylationERDDDDDMethylationMitochondrionPhosphorylationCYReactions through unknown mechanisms/moleculesCY -> NUInhibitionCY -> NUMTMolecular associationDeacetylationPhosphorylationCytoplasmCY -> NUExtracellularNucleusPalmitolyationPMDeubiquitinationActivationControlGene SymbolRecruitmentSumoylationNUCY -> NUGlycosylationCY -> NUReceptorCY -> NUCY -> NUMTEndoplasmic reticulumENDDCY -> NUDemethylationDProteins in a complex interactionPlasma membraneDDUbiquitinationDProteolytic cleavageNucleus(Protein-protein interaction)EndosomeTranslocationDephosphorylationGolgi apparatusECCY -> PMPM -> CYAccession Number: NetPath 14DLigandNUAutophosphorylationEnzyme complexAcetylationGOcrkmapk3grb2ets1aSOS1raf1cishzgc:172209socs1IL2LOC792354ybx1IL2RAgnb2l1pik3r2STAT5Bmap2k1tertrelaIL2RBICAM1prkczraf1jak1hsp90a.2LOC792354NFKB1BCL2fynbptpn6tertstam2ybx1LOC564517LOC559281SOCS3IRS2STAT5Afrap1zgc:92124mknk1JAK3mapk1LOC100149273IL2jak2bLOC563639LOC561737IL2crklkraszgc:92106LOC792354rps6kb1NMIwu:fb92a07IFNA1NFKB1IL2ptk2bbIL2zgc:101581zgc:172250stamSHBstat1azgc:64051eif3bitm2basykfoxo5IL2RGcreb1mapk1mapk3LOC557176VAV1nr3c1crkpik3cdmapkapk2acblstat3STAT5ASTAT5Brelaptpn11PLCB1LCKchukzgc:77033mapk14a


Description

IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 71% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
89852view12:18, 6 October 2016Mkutmonremove GenMAPP notes
89848view12:16, 6 October 2016MkutmonModified description
70236view21:24, 15 July 2013MaintBotupdated to 2013 schema
67367view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
40829view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35786view06:21, 13 February 2010MaintBotAdded description
34215view21:33, 9 December 2009MaintBotAutomatic update of empty xrefs
31348view20:29, 13 August 2009MaintBotFixed text labels
31029view01:13, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BCL2GeneProduct570772 (Entrez Gene)
ICAM1GeneProduct
IFNA1GeneProduct
IL2GeneProduct
IL2RAGeneProduct
IL2RBGeneProduct793920 (Entrez Gene)
IL2RGGeneProduct
IRS2GeneProduct
JAK3GeneProduct561370 (Entrez Gene)
LCKGeneProduct414333 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC559281GeneProduct559281 (Entrez Gene)
LOC561737GeneProduct561737 (Entrez Gene)
LOC563639GeneProduct563639 (Entrez Gene)
LOC564517GeneProduct564517 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
NFKB1GeneProduct565756 (Entrez Gene)
NMIGeneProduct335331 (Entrez Gene)
PLCB1GeneProduct
SHBGeneProduct
SOCS3GeneProduct
SOS1GeneProduct
STAT5AGeneProduct
STAT5BGeneProduct
VAV1GeneProduct
cblGeneProduct492364 (Entrez Gene)
chukGeneProduct393287 (Entrez Gene)
cishGeneProduct767678 (Entrez Gene)
creb1GeneProduct573207 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
crklGeneProduct556443 (Entrez Gene)
eif3bGeneProduct796380 (Entrez Gene)
ets1aGeneProduct280651 (Entrez Gene)
foxo5GeneProduct30296 (Entrez Gene)
frap1GeneProduct324254 (Entrez Gene)
fynbGeneProduct574422 (Entrez Gene)
gnb2l1GeneProduct30722 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
hsp90a.2GeneProduct565155 (Entrez Gene)
itm2baGeneProduct323632 (Entrez Gene)
jak1GeneProduct30280 (Entrez Gene)
jak2bGeneProduct30298 (Entrez Gene)
krasGeneProduct445289 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mapkapk2aGeneProduct327321 (Entrez Gene)
mknk1GeneProduct555974 (Entrez Gene)
nr3c1GeneProduct553740 (Entrez Gene)
pik3cdGeneProduct394174 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
ptk2bbGeneProduct245950 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
ptpn6GeneProduct335573 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
relaGeneProduct415099 (Entrez Gene)
rps6kb1GeneProduct406349 (Entrez Gene)
socs1GeneProduct445073 (Entrez Gene)
stam2GeneProduct492497 (Entrez Gene)
stamGeneProduct386967 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
sykGeneProduct405769 (Entrez Gene)
tertGeneProduct796551 (Entrez Gene)
wu:fb92a07GeneProduct100002263 (Entrez Gene)
ybx1GeneProduct58144 (Entrez Gene)
zgc:101581GeneProduct493617 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zgc:64051GeneProduct393342 (Entrez Gene)
zgc:77033GeneProduct406598 (Entrez Gene)
zgc:92106GeneProduct326672 (Entrez Gene)
zgc:92124GeneProduct447804 (Entrez Gene)

Annotated Interactions

No annotated interactions
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