Signal Transduction of S1P Receptor (Rattus norvegicus)

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1GPCRs similar to S1PS1pr2Akt3LOC100912585Smpd2Mapk4Racgap1Pik3c2bAsah1Gnai1S1pr3Plcb2Akt2Mapk1Gnai3S1pr5S1pr1Mapk12Gnai2Mapk3Plcb1Plcb3Akt1Sphk2Mapk6Sphk1


Description

Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation.

Comments

GenMAPP notes 
Representation of Figure 2. from T. Hla, et al. 2001, Science, 294, pg. 1877
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP26 (r79950) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ; ''Lysophospholipids--receptor revelations.''; Science, 2001 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
95803view14:52, 19 January 2018MkutmonHomology conversion update
69429view19:03, 8 July 2013MaintBotUpdated to 2013 gpml schema
67642view11:43, 26 June 2013DdiglesOntology Term : 'sphingosine 1-phosphate signaling pathway' added !
41753view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
34124view19:27, 9 December 2009MaintBotAutomatic update of empty xrefs
31909view12:49, 14 August 2009MaintBotFixed group labels
31021view01:08, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Akt1GeneProductENSRNOG00000028629 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:207
Akt2GeneProductENSRNOG00000018677 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:208
Akt3GeneProductENSRNOG00000021497 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10000
Asah1GeneProductENSRNOG00000010034 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:427
Gnai1GeneProductENSRNOG00000057096 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2770
Gnai2GeneProductENSRNOG00000016592 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2771
Gnai3GeneProductENSRNOG00000019465 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2773
LOC100912585GeneProductENSRNOG00000002412 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5598
Mapk12GeneProductENSRNOG00000031233 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6300
Mapk1GeneProductENSRNOG00000001849 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5594
Mapk3GeneProductENSRNOG00000053583 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5595
Mapk4GeneProductENSRNOG00000015401 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5596
Mapk6GeneProductENSRNOG00000009381 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5597
Pik3c2bGeneProductENSRNOG00000029938 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5287
Plcb1GeneProductENSRNOG00000004810 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23236
Plcb2GeneProductENSRNOG00000058337 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5330
Plcb3GeneProductENSRNOG00000021150 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5331
Racgap1GeneProductENSRNOG00000049033 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:29127
S1pr1GeneProductENSRNOG00000013683 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1901
S1pr2GeneProductENSRNOG00000020653 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9294
S1pr3GeneProductENSRNOG00000014524 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1903
S1pr5GeneProductENSRNOG00000020901 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:53637
Smpd2GeneProductENSRNOG00000000306 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6610
Sphk1GeneProductENSRNOG00000010626 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8877
Sphk2GeneProductENSRNOG00000021032 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:56848

Annotated Interactions

No annotated interactions
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