Selenium Micronutrient Network (Rattus norvegicus)

From WikiPathways

Jump to: navigation, search
Unspecified interactions GENERIC ENZYMEPositive effect REACTIONINORGANIC IONMETABOLITEInfluence on expression Transformation TransportNegative effect BindingPLASMAGENERIC BINDING PROTEININTRACELULARPGD2PGE2H2O2RiboflavinROSUric Acid5-HPETETNADPLeukotrieneE4Gpx3BRNS15-HETEBKmoBTMtrPNPOIEa-TocopherolFADTLipoxin A4TRXR 1PGI2PGG2BNADPH15-HETEPGF2aDHA (n-3)Gpx2Ascorbic acidPGD2Tbxas1BBEndoperoxidaseCOX2HemeNiacinZincC22:5 (n-6)Leukotriene F4PtgdsPGF2aBALA (n-3)IronAscorbic acidPGFSBCopperLeukotriene D4XanthineTromboxane A2EPA (n-3)PGG3PGE3Thromboxane A2Leukotriene A4BMethionine sulfoxideAA (n-6)Lipoxin B4Fads2Leukotriene B4Pyridoxal 5'-phosphatePGH3PGH2TGsrFMNDHA (n-3)Gpx1ALA (n-3)Leukotriene C4BSelRSelkLeukotriene D4AA (n-6)a-tocopherolNADPFolic acidHypoxanthine COX1TryptophanCatPtgisBd4 desaturaseLeukotriene E4Lipoxin A4GlutathioneHomocysteineGpx4BC22:5 (n-6)BPGE2Leukotriene B4BTBTFolic acidBTXdhBHomocysteineSepp1LA (n-6)TRXR 3Thromboxane B2BIronNADPHLA (n-6)EPA (n-3)Uric acidLeukotriene C4BIETNGpx6TRXR 2iPF2-alphaGlutathionePGI2Methionine HypoxanthineManganeseMthfrBBBMethionineZincVitamin B12CopperPyridoxal 5'-phosphateTSeleniumTSelWTNAlox5BFads1H2OSod1Bglutathione disulfideCysteineBSeleniumPtgesO2Vitamin B12ThioredoxinCysteineF2-IsoprostaneBLipoic acid21


Description

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP15(r29615) with a 55% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Guzik TJ, Korbut R, Adamek-Guzik T.; ''Nitric oxide and superoxide in inflammation and immune regulation.''; J Physiol Pharmacol., 2003 PubMed Europe PMC
  2. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, Cirino M, Girard Y, Larue M, Rokach J.; ''Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.''; Prostaglandins., 1982 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106962view13:42, 17 September 2019MaintBotHMDB identifier normalization
91818view06:29, 31 March 2017EgonwROS is a metabolite, and better annotated with the matching Wikidata ID.
87652view08:54, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
82693view18:05, 22 October 2015EgonwFixed a typo.
73553view18:32, 30 January 2014EgonwH2O not H20....
71774view20:30, 17 October 2013MaintBotAutomated update of data sources
69346view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
69078view18:09, 8 July 2013EgonwReplaced an outdated HMDB identifier with the 3.5 one.
68388view10:11, 4 July 2013EgonwMade the link to Wikipedia machine readable.
68387view10:08, 4 July 2013EgonwFixed a number of DataNode types.
66317view17:34, 17 June 2013MaintBotModified title
58922view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58521view20:15, 14 February 2013MaintBotModified title
41659view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
34057view19:04, 9 December 2009MaintBotAutomatic update of empty xrefs
31907view12:48, 14 August 2009MaintBotFixed group labels
31015view01:06, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
15-HETEMetaboliteHMDB0011134 (HMDB)
5-HPETEMetaboliteHMDB0001193 (HMDB)
AA (n-6)MetaboliteHMDB0001043 (HMDB)
ALA (n-3)MetaboliteHMDB0001388 (HMDB)
Alox5Protein25290 (Entrez Gene)
Ascorbic acidMetaboliteHMDB0000044 (HMDB)
BMetabolite
C22:5 (n-6)MetaboliteHMDB0001976 (HMDB)
COX1Protein26195 (Entrez Gene)
COX2Protein26198 (Entrez Gene)
CatProtein24248 (Entrez Gene)
CopperMetaboliteHMDB0000657 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
DHA (n-3)MetaboliteHMDB0002183 (HMDB)
EPA (n-3)MetaboliteHMDB0001999 (HMDB)
EndoperoxidaseProtein
F2-IsoprostaneMetaboliteHMDB0004659 (HMDB)
FADMetaboliteHMDB0001248 (HMDB)
FMNGeneProduct342184 (Entrez Gene)
Fads1Protein84575 (Entrez Gene)
Fads2Protein83512 (Entrez Gene)
Folic acidMetaboliteHMDB0000121 (HMDB)
GlutathioneMetaboliteHMDB0000125 (HMDB)
Gpx1Protein24404 (Entrez Gene)
Gpx2Protein29326 (Entrez Gene)
Gpx3Protein64317 (Entrez Gene)
Gpx4Protein29328 (Entrez Gene)
Gpx6Protein259233 (Entrez Gene)
GsrProteinENSRNOG00000014915 (Ensembl)
H2O2MetaboliteHMDB0003125 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
HemeMetaboliteHMDB0003178 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
Hypoxanthine MetaboliteHMDB0000157 (HMDB)
HypoxanthineMetaboliteHMDB0000157 (HMDB)
IEMetabolite
IronMetaboliteHMDB0000692 (HMDB)
KmoProtein59113 (Entrez Gene)
LA (n-6)MetaboliteHMDB0000673 (HMDB)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
Leukotriene F4MetaboliteHMDB0006465 (HMDB)
LeukotrieneE4MetaboliteHMDB0002200 (HMDB)
Lipoic acidMetabolite
Lipoic acidMetaboliteHMDB0001451 (HMDB)
Lipoxin A4MetaboliteHMDB0004385 (HMDB)
Lipoxin B4MetaboliteHMDB0005082 (HMDB)
ManganeseMetaboliteHMDB0001333 (HMDB)
Methionine MetaboliteHMDB0000696 (HMDB)
Methionine sulfoxideMetaboliteHMDB0002005 (HMDB)
MethionineMetaboliteHMDB0000696 (HMDB)
MthfrProtein362657 (Entrez Gene)
MtrProtein81522 (Entrez Gene)
NADPHMetaboliteHMDB0000221 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
NiacinMetaboliteHMDB0001406 (HMDB)
O2MetaboliteHMDB0001377 (HMDB)
PGD2MetaboliteHMDB0001403 (HMDB)
PGE2Metabolite
PGE3MetaboliteHMDB0002664 (HMDB)
PGF2aMetaboliteHMDB0001139 (HMDB)
PGFSProtein
PGG2MetaboliteHMDB0003235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB0001381 (HMDB)
PGH3Metabolite
PGI2MetaboliteHMDB0001335 (HMDB)
PNPOProtein64533 (Entrez Gene)
PtgdsProtein25526 (Entrez Gene)
PtgesProtein59103 (Entrez Gene)
PtgisProtein25527 (Entrez Gene)
Pyridoxal 5'-phosphateMetaboliteHMDB0001491 (HMDB)
RNSMetabolite
ROSMetaboliteQ424361 (Wikidata) http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB0000244 (HMDB)
SelRGeneProduct51734 (Entrez Gene)
SelWGeneProduct6415 (Entrez Gene)
SeleniumMetaboliteHMDB0001349 (HMDB)
SelkProtein290549 (Entrez Gene)
Sepp1Protein29360 (Entrez Gene)
Sod1Protein24786 (Entrez Gene)
TMetabolite
TGeneProduct292301 (Entrez Gene)
TNMetabolite
TRXR 1GeneProduct7296 (Entrez Gene)
TRXR 2GeneProduct10587 (Entrez Gene)
TRXR 3GeneProduct114112 (Entrez Gene)
Tbxas1Protein24886 (Entrez Gene)
ThioredoxinProtein7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)
Tromboxane A2MetaboliteHMDB0001452 (HMDB)
TryptophanMetaboliteHMDB0000929 (HMDB)
Uric AcidMetaboliteHMDB0000289 (HMDB)
Uric acidMetabolite
Vitamin B12MetaboliteHMDB0002174 (HMDB)
XanthineMetaboliteHMDB0000292 (HMDB)
XdhProtein497811 (Entrez Gene)
ZincMetaboliteHMDB0001303 (HMDB)
a-TocopherolMetaboliteHMDB0001893 (HMDB)
a-tocopherolMetaboliteHMDB0001893 (HMDB)
d4 desaturaseProtein
glutathione disulfideMetaboliteHMDB0000656 (HMDB)
iPF2-alphaMetaboliteHMDB0004659 (HMDB)

Annotated Interactions

No annotated interactions
Personal tools