Toll-like receptor signaling pathway (Rattus norvegicus)

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NK cell)+pChemotactic+p(Neutrophil, immature DC,(Mycobacteria)cytokine receptorImidazoquinolinChemotactic+p+pCostimulatory moleculeseffectsInflammatory cytokinesCpG DNAFlagellar assembly+pEndosomeComplement andLPS(G-)Peptidoglycan(G+)LipoproteinCytokine-DegradationLipoarabinomannan+Autocrine / Paracrine+pinteractionIKKAntiviral effects+p+pdsRNAT cell stimulationUbiquitin mediated proteolysisInflammatory cytokines(anti-viral compounds)biosynthesis(T cell)MyD88-independent pathwayProinflammatoryUnmethylatedSpecific pathwayin pDCsMAPK signaling pathwayApoptosiscoagulation cascades+p+p+pMyD88-dependent pathway+pDNAeffectseffectsssRNAFlagellin+p+Lipopolysaccharide+p+pZymosan (Yeast)Jak-STAT signaling pathwayMyd88JunRac1IFNA5Tlr3Cd40Map3k7IFNA2Il12bPik3cgIrak1Map2k4Map2k3Irf3Pik3cdAkt2TLR1Myd88TnfLY96Pik3r2IFNA6Cd80Pik3r5Nfkb1Tlr7IkbkgIFNA7Mapk10Tlr5Mapk9Ripk1FaddTraf6IFNA13Tlr2Irf5Cxcl9Myd88PIK3CAIFNA17Ticam2Mapk1Mapk14Stat1Mapk11Tlr4NfkbiaIkbkbIrf7Map2k6Akt3ChukRelaCcl4IFNA21Map2k2Tbk1Nfkb1Map3k7ip2Cd14Pik3r1IFNA1Myd88Akt1Mapk12TLR9TirapIkbkeCasp8IL8Traf6Irak1Ifnb1Map2k7Pik3cbTraf3Cxcl10Pik3r3IFNA8TICAM1TLR8Ccl5IFNA4Il12aIFNA14Ifnb1Nfkb2Irak4Cd86Spp1LbpIl1bTraf6Mapk8Ifnar1Tlr6IFNA10CCL3ChukMap2k1IFNA16IFNAR2Cxcl11Irak4TirapMapk13Mapk3Il6Ifnb1TollipFosTlr2Map3k8MAP3K7IP1


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 80% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
72183view07:18, 27 October 2013EgonwAdded a metabolite ID for imidazoquinolin.
69370view18:55, 8 July 2013MaintBotUpdated to 2013 gpml schema
67704view11:52, 26 June 2013DdiglesOntology Term : 'Toll-like receptor signaling pathway' added !
41684view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
34073view19:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32312view13:21, 15 August 2009MaintBotFixed text labels
31905view12:48, 14 August 2009MaintBotFixed group labels
31341view20:26, 13 August 2009MaintBotFixed text labels
31007view01:03, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Akt2GeneProduct25233 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
Akt3GeneProduct29414 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CCL3GeneProduct25542 (Entrez Gene) Original kegg element: gene;44;hsa:6348
Casp8GeneProduct64044 (Entrez Gene) Original kegg element: gene;87;hsa:841
Ccl4GeneProduct116637 (Entrez Gene) Original kegg element: gene;38;hsa:6351
Ccl5GeneProduct81780 (Entrez Gene) Original kegg element: gene;58;hsa:6352
Cd14GeneProduct60350 (Entrez Gene) Original kegg element: gene;84;hsa:929
Cd40GeneProduct171369 (Entrez Gene) Original kegg element: gene;29;hsa:958
Cd80GeneProduct25408 (Entrez Gene) Original kegg element: gene;69;hsa:941
Cd86GeneProduct56822 (Entrez Gene) Original kegg element: gene;28;hsa:942
ChukGeneProduct309361 (Entrez Gene) Original kegg element: gene;42;hsa:1147
Cxcl10GeneProduct245920 (Entrez Gene) Original kegg element: gene;25;hsa:3627
Cxcl11GeneProduct305236 (Entrez Gene) Original kegg element: gene;23;hsa:6373
Cxcl9GeneProduct246759 (Entrez Gene) Original kegg element: gene;24;hsa:4283
FaddGeneProduct266610 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FosGeneProduct314322 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA10GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct298210 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct298207 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProduct298213 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct298205 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct690894 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR2GeneProductOriginal kegg element: gene;49;hsa:3454 hsa:3455
IL8GeneProductOriginal kegg element: gene;43;hsa:3576
Ifnar1GeneProduct288264 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
Ifnb1GeneProduct24481 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IkbkbGeneProduct84351 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IkbkeGeneProduct363984 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IkbkgGeneProduct309295 (Entrez Gene) Original kegg element: gene;85;hsa:8517
Il12aGeneProduct84405 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
Il12bGeneProduct64546 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
Il1bGeneProduct24494 (Entrez Gene) Original kegg element: gene;51;hsa:3553
Il6GeneProduct24498 (Entrez Gene) Original kegg element: gene;57;hsa:3569
ImidazoquinolinMetabolite14697812 (Chemspider)
Irak1GeneProduct363520 (Entrez Gene) Original kegg element: gene;41;hsa:3654
Irak4GeneProduct300177 (Entrez Gene) Original kegg element: gene;86;hsa:51135
Irf3GeneProduct292892 (Entrez Gene) Original kegg element: gene;67;hsa:3661
Irf5GeneProduct296953 (Entrez Gene) Original kegg element: gene;21;hsa:3663
Irf7GeneProduct293624 (Entrez Gene) Original kegg element: gene;20;hsa:3665
JunGeneProduct24516 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LY96GeneProduct448830 (Entrez Gene) Original kegg element: gene;71;hsa:23643
LbpGeneProduct29469 (Entrez Gene) Original kegg element: gene;77;hsa:3929
MAP3K7IP1GeneProduct315139 (Entrez Gene) Original kegg element: gene;59;hsa:10454
Map2k1GeneProduct170851 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
Map2k2GeneProduct58960 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
Map2k3GeneProduct303200 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
Map2k4GeneProduct287398 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
Map2k6GeneProduct114495 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
Map2k7GeneProduct363855 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
Map3k7GeneProduct313121 (Entrez Gene) Original kegg element: gene;37;hsa:6885
Map3k7ip2GeneProduct308267 (Entrez Gene) Original kegg element: gene;61;hsa:23118
Map3k8GeneProduct116596 (Entrez Gene) Original kegg element: gene;13;hsa:1326
Mapk10GeneProduct25272 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Mapk1GeneProduct116590 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
Mapk11GeneProduct689314 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk12GeneProduct60352 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk13GeneProduct29513 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk14GeneProduct81649 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
Mapk3GeneProduct50689 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
Mapk8GeneProduct116554 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Mapk9GeneProduct50658 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
Myd88GeneProduct301059 (Entrez Gene) Original kegg element: gene;47;hsa:4615
Nfkb1GeneProduct81736 (Entrez Gene) Original kegg element: gene;14;hsa:4790
Nfkb2GeneProduct309452 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NfkbiaGeneProduct25493 (Entrez Gene) Original kegg element: gene;64;hsa:4792
PIK3CAGeneProduct170911 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cbGeneProduct85243 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cdGeneProduct366508 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3cgGeneProduct298947 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r1GeneProduct25513 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r2GeneProduct29741 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r3GeneProduct60664 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Pik3r5GeneProduct497931 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
Rac1GeneProduct363875 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RelaGeneProduct309165 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
Ripk1GeneProduct306886 (Entrez Gene) Original kegg element: gene;17;hsa:8737
Spp1GeneProduct25353 (Entrez Gene) Original kegg element: gene;15;hsa:6696
Stat1GeneProduct25124 (Entrez Gene) Original kegg element: gene;62;hsa:6772
TICAM1GeneProductOriginal kegg element: gene;82;hsa:148022
TLR1GeneProduct305354 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR8GeneProduct684440 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct338457 (Entrez Gene) Original kegg element: gene;78;hsa:54106
Tbk1GeneProduct299827 (Entrez Gene) Original kegg element: gene;52;hsa:29110
Ticam2GeneProduct364867 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TirapGeneProduct680127 (Entrez Gene) Original kegg element: gene;83;hsa:114609
Tlr2GeneProduct310553 (Entrez Gene) Original kegg element: gene;74;hsa:7097
Tlr3GeneProduct364594 (Entrez Gene) Original kegg element: gene;73;hsa:7098
Tlr4GeneProduct29260 (Entrez Gene) Original kegg element: gene;79;hsa:7099
Tlr5GeneProduct289337 (Entrez Gene) Original kegg element: gene;72;hsa:7100
Tlr6GeneProduct305353 (Entrez Gene) Original kegg element: gene;76;hsa:10333
Tlr7GeneProduct317468 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TnfGeneProduct24835 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TollipGeneProduct361677 (Entrez Gene) Original kegg element: gene;81;hsa:54472
Traf3GeneProduct362788 (Entrez Gene) Original kegg element: gene;16;hsa:7187
Traf6GeneProduct311245 (Entrez Gene) Original kegg element: gene;53;hsa:7189

Annotated Interactions

No annotated interactions
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