DNA Replication (Saccharomyces cerevisiae)

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1-35. Leading/lagging strand synthesis1. Assembly of the pre-replicative complexRNA primer-DNA primer:origin duplex:PCNAUbiquitinp180Mcm 4,6,7 trimer forms and associates with the replication forkUbiquitinDNA polymerase alpha: primase: origin complexDNA Polymerase ARFC36RNA primer-DNA primerProcessive complexPhosphorylation of MCM2-7PrimaseDNA polymerase alpha: primase: origin complexRFC Heteropentamer:RNA primer-DNA primer:PCNA homotrimerUTPPre-replicative complex2. Activation of the pre-replicative complexOriginRFC40Degraded by proteasome in cytosolRFC38RFC373. DNA replication initiationCTPDegraded by proteasome in cytosolp70Pre-replicative complexRFC140RNA primer-DNA primer4. Switching of origins to post-replicative statep49dUTPRFC Heteropentamer:RNA primer-DNA primerp58RNA PrimerCDC54ASKORC3LCDT1POLD3RFA1POL2PRI1HYS2MCM6UBI4ADPCDC6RPL40ACDC46RPA3RFC4ORC5LPOL30dCTPCDC45POL12ORC2PRI2CDC2MCM2ATPdGTPRFC5ATPMCM10GMNNCDT1ORC6LPOL1ORC4LDPB2CDC47ATPRFA2RFC1CDK2dATPORC1LRPA4CDC7ADPRFC2RFC3GTPMCM3POLD4ATPORC2ORC3LORC2ORC3LORC5LORC2ORC3LORC5LORC4LORC2ORC3LORC5LORC4LORC1LORC2ORC3LORC5LORC4LORC1LORC6LORC2ORC3LORC5LORC4LORC1LORC6LCDC6ORC2ORC3LORC5LORC4LORC1LORC6LCDC6CDT1MCM3MCM2CDC54CDC46MCM6CDC47ORC2ORC3LORC5LORC4LORC1LORC6LCDC6CDT1MCM3MCM2CDC54CDC46MCM6CDC47ORC2ORC3LORC5LORC4LORC1LORC6LCDC6CDT1MCM10GMNNMCM10MCM3MCM2CDC54CDC46MCM6CDC47ORC2ORC3LORC5LORC4LORC1LORC6LCDC6CDT1CDT1MCM10MCM3PMCM2PCDC54CDC46PMCM6PPCDC47PORC2ORC3LORC5LORC4LORC1LORC6LCDC6CDT1ORC1LPORC1LUbCDC6PCDC6Ub


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

Source: [wikipedia:DNA_replication|Wikipedia]

http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306

Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed
  2. Marahrens Y, Stillman B; ''A yeast chromosomal origin of DNA replication defined by multiple functional elements.''; Science, 1992 PubMed
  3. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed

History

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CompareRevisionActionTimeUserComment
78398view10:25, 7 January 2015MaintBotadded missing graphIds
76275view21:24, 25 June 2014KhanspersModified description
76274view21:24, 25 June 2014Khanspersremoved genmapp comments
76273view21:22, 25 June 2014Khanspersoverhaul
71354view18:03, 17 October 2013MaintBotAutomated update of data sources
69761view11:05, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69672view20:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
67159view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41916view04:54, 2 March 2011MaintBotRemoved redundant pathway information and comments
35199view15:38, 11 February 2010ThomasModified description
35198view15:38, 11 February 2010ThomasModified description
35197view15:37, 11 February 2010Thomasadded literature
34367view22:36, 9 December 2009MaintBotAutomatic update of empty xrefs
20699view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:DNA replication Reactome]] moved to [[Pathway:WP13]]: Moved to stable identifier
12692view07:58, 17 May 2008MaintBotautomated metabolite conversion
8540view14:02, 7 January 2008MaintBotAdded to category $category
19420view14:02, 7 January 2008D.KorenUploaded new pathway
8538view14:02, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite58-64-0 (CAS)
ASKGeneProduct
ATPMetabolite1927-31-7 (CAS)
CDC2GeneProduct851456 (Entrez Gene)
CDC45GeneProduct850793 (Entrez Gene)
CDC46GeneProduct850980 (Entrez Gene)
CDC47GeneProduct852501 (Entrez Gene)
CDC54GeneProduct856130 (Entrez Gene)
CDC6GeneProduct853244 (Entrez Gene)
CDC7GeneProduct851545 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
CDT1ProteinP47112 (Uniprot-TrEMBL)
DPB2GeneProduct856305 (Entrez Gene)
GMNNGeneProduct
GTPMetabolite2564-35-4 (CAS)
HYS2GeneProduct853462 (Entrez Gene)
MCM10GeneProduct854656 (Entrez Gene)
MCM2GeneProduct852258 (Entrez Gene)
MCM3GeneProduct856680 (Entrez Gene)
MCM6GeneProduct852673 (Entrez Gene)
ORC1LGeneProduct
ORC2GeneProduct852352 (Entrez Gene)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
POL12GeneProduct852245 (Entrez Gene)
POL1GeneProduct855621 (Entrez Gene)
POL2GeneProduct855459 (Entrez Gene)
POL30GeneProduct852385 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
PRI1GeneProduct854825 (Entrez Gene)
PRI2GeneProduct853821 (Entrez Gene)
RFA1GeneProduct851266 (Entrez Gene)
RFA2GeneProduct855404 (Entrez Gene)
RFC1GeneProduct854392 (Entrez Gene)
RFC2GeneProduct853531 (Entrez Gene)
RFC3GeneProduct855426 (Entrez Gene)
RFC4GeneProduct854059 (Entrez Gene)
RFC5GeneProduct852383 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RPL40AGeneProduct854658 (Entrez Gene)
UBI4GeneProduct850620 (Entrez Gene)
dATPMetabolite1927-31-7 (CAS)
dCTPMetabolite2056-98-6 (CAS)
dGTPMetabolite2564-35-4 (CAS)

Annotated Interactions

No annotated interactions

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