1PDGF-BB complexBoneOsteoclastOsteoclast activationH+RANKPDGFBNa+/H+ transporterTRAPRANK ligandOsteopontinPDGFBPiOGR1IFN-bNa+Ca2+MAPK8Cathepsin KTRAPCathepsin KNa+H+H+AIMP2H+Type 1 interferon receptorH+ ATPaseH+Ca2+OPGb3 integrinTRPV