Type II interferon signaling (IFNG) (Rattus norvegicus)

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1P[P]BORORPCytoplasm-P[P]NucleusOBO&BExtracellularSpacePAP&TTORORORBT[P] [P]B[P]PPlasmaMembraneTap1CybbEif2ak2IFNAStat1Irf9Irf9Irf9G1p2Jak2Stat2Jak2Ifngr1Nos2Icam1Stat1IfngIrf1Stat1Stat2Ifngr2Stat1Ifnb1Ptpn11PrkcdJak1Cxcl10HIST2H4Stat1CiitaIfngr2Irf9IfngStat2HLA-BJak2Stat1Jak2Stat1G1P3Jak1Irf8Oas1aIfngr1Psmb9Gbp1Socs1Ifngr1Cxcl9Stat1Ifngr1Stat1Stat1Irf9Irf9Il1bReg1aStat1Stat1Jak1Ifit2Stat1Jak1Stat1Irf8Socs3Irf4Irf2Irf9Ifngr2Stat1Stat1IfngIfngIfngStat1Sfpi1Ifngr2Stat2


Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]


This pathway was inferred from Homo sapiens pathway WP619(r28124) with a 94% conversion rate.

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Ontology Terms



  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed Europe PMC


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86846view14:53, 13 July 2016MkutmonOntology Term : 'type II interferon signaling pathway' added !
86845view14:53, 13 July 2016MkutmonOntology Term : 'PW:0000896' removed !
69366view18:54, 8 July 2013MaintBotUpdated to 2013 gpml schema
67732view11:56, 26 June 2013DdiglesOntology Term : 'Type II interferon signaling pathway' added !
41680view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
34070view19:09, 9 December 2009MaintBotAutomatic update of empty xrefs
32305view13:18, 15 August 2009MaintBotFixed text labels
31889view12:43, 14 August 2009MaintBotFixed group labels
31334view20:23, 13 August 2009MaintBotFixed text labels
30961view00:46, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CiitaGeneProduct85483 (Entrez Gene)
Cxcl10GeneProduct245920 (Entrez Gene)
Cxcl9GeneProduct246759 (Entrez Gene)
CybbGeneProduct66021 (Entrez Gene)
Eif2ak2GeneProduct54287 (Entrez Gene)
G1p2GeneProduct298693 (Entrez Gene)
Gbp1GeneProduct304266 (Entrez Gene)
HIST2H4GeneProduct295277 (Entrez Gene)
Icam1GeneProduct25464 (Entrez Gene)
Ifit2GeneProduct294091 (Entrez Gene)
Ifnb1GeneProduct24481 (Entrez Gene)
IfngGeneProduct25712 (Entrez Gene)
Ifngr1GeneProduct116465 (Entrez Gene)
Ifngr2GeneProduct360697 (Entrez Gene)
Il1bGeneProduct24494 (Entrez Gene)
Irf1GeneProduct24508 (Entrez Gene)
Irf2GeneProduct290749 (Entrez Gene)
Irf4GeneProduct291100 (Entrez Gene)
Irf8GeneProduct292060 (Entrez Gene)
Irf9GeneProduct305896 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
Nos2GeneProduct24599 (Entrez Gene)
Oas1aGeneProduct192281 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
Psmb9GeneProduct24967 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
Reg1aGeneProduct24714 (Entrez Gene)
Sfpi1GeneProduct366126 (Entrez Gene)
Socs1GeneProduct252971 (Entrez Gene)
Socs3GeneProduct89829 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat2GeneProduct288774 (Entrez Gene)
Tap1GeneProduct24811 (Entrez Gene)

Annotated Interactions

No annotated interactions
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