Hypothetical Network for Drug Addiction (Rattus norvegicus)

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1MAPK signaling pathwayAMPARRegulation of actin cytoskeletonStrong depolarizationRegulation of gap junctionGnRH Signal pathwayNeuroactive ligand-receptorinteractionLong-term potentiationmGluRLocal TranslationGonadotropins gene expression & secretionNMDARGap junctionDrd2Grm1Grin2bAdcy1Gria3PrkacaPrkceCamk4Gria2Grm5Drd1aDrd4Mapk1Grin2aNischZhx2D-GlutamateCyclic AMPMap2k1Adcy8Gria4GsTerf2ipGiGrin1PrkacaGrin2cconnexinMapk3Grin2dCamk2bKrit1Creb1connexinActa1GRIA1Adcy1Ppa1Map2k2Ca++


Adapted from figure 2 in Li et al..


This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 86% conversion rate.

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Ontology Terms



  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC


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107230view14:32, 17 September 2019MaintBotChEBI identifier normalization
102278view08:36, 17 December 2018EgonwReplaced the ChEBI idea of Ca(0) with that of Ca2++
69367view18:54, 8 July 2013MaintBotUpdated to 2013 gpml schema
67353view10:41, 26 June 2013Christine ChichesterOntology Term : 'substance dependence disease pathway' added !
41681view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
34071view19:10, 9 December 2009MaintBotAutomatic update of empty xrefs
32302view13:17, 15 August 2009MaintBotFixed text labels
31881view12:41, 14 August 2009MaintBotFixed group labels
31331view20:22, 13 August 2009MaintBotFixed text labels
30937view00:39, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Acta1GeneProduct29437 (Entrez Gene)
Adcy1GeneProduct305509 (Entrez Gene)
Adcy8GeneProduct29241 (Entrez Gene)
Ca++MetaboliteCHEBI:29108 (ChEBI)
Camk2bGeneProduct24245 (Entrez Gene)
Camk4GeneProduct25050 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
Cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
D-GlutamateMetaboliteCHEBI:15966 (ChEBI)
Drd1aGeneProduct24316 (Entrez Gene)
Drd2GeneProduct24318 (Entrez Gene)
Drd4GeneProduct25432 (Entrez Gene)
GRIA1GeneProduct50592 (Entrez Gene)
Gria2GeneProduct29627 (Entrez Gene)
Gria3GeneProduct29628 (Entrez Gene)
Gria4GeneProduct29629 (Entrez Gene)
Grin1GeneProduct24408 (Entrez Gene)
Grin2aGeneProduct24409 (Entrez Gene)
Grin2bGeneProduct24410 (Entrez Gene)
Grin2cGeneProduct24411 (Entrez Gene)
Grin2dGeneProduct24412 (Entrez Gene)
Grm1GeneProduct24414 (Entrez Gene)
Grm5GeneProduct24418 (Entrez Gene)
Krit1GeneProduct362317 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Map2k2GeneProduct58960 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
NischGeneProduct306255 (Entrez Gene)
Ppa1GeneProduct294504 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene)
Terf2ipGeneProduct307861 (Entrez Gene)
Zhx2GeneProduct314988 (Entrez Gene)

Annotated Interactions

No annotated interactions
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