Keap1-Nrf2 (Rattus norvegicus)

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1CCAAT/XREPhase II enzymesARET-PS-PNucleusS-PT-PCurcuminCaffeic acid phenethyl esterNqo1Keap1CebpbGSTA2MafGclcEphb2Mapk8SulforaphanePI3KNfe2l2Jtv1PrkcaNfe2l2Hmox1Nfe2l2CebpbKeap16-HITCGclm



This pathway was inferred from Homo sapiens pathway WP3(r29720) with a 88% conversion rate.

Quality Tags

Ontology Terms



  1. Surh YJ; ''Cancer chemoprevention with dietary phytochemicals.''; Nat Rev Cancer, 2003 PubMed Europe PMC


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106949view13:41, 17 September 2019MaintBotHMDB identifier normalization
69424view19:02, 8 July 2013MaintBotUpdated to 2013 gpml schema
67420view10:59, 26 June 2013DdiglesOntology Term : 'nuclear factor, erythroid derived 2, like 2 signaling pathway' added !
48260view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41747view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
34118view19:26, 9 December 2009MaintBotAutomatic update of empty xrefs
31880view12:40, 14 August 2009MaintBotFixed group labels
30935view00:38, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
6-HITCMetaboliteFull name: 6-(Methylsulfinyl)hexylisothiocyanate, or Japanese horseradish wasabi
Caffeic acid phenethyl esterMetabolite
CebpbGeneProduct24253 (Entrez Gene)
CurcuminMetaboliteHMDB0002269 (HMDB)
Ephb2GeneProduct313633 (Entrez Gene)
GSTA2GeneProduct24422 (Entrez Gene)
GclcGeneProduct25283 (Entrez Gene)
GclmGeneProduct29739 (Entrez Gene)
Hmox1GeneProduct24451 (Entrez Gene)
Jtv1GeneProduct288480 (Entrez Gene)
Keap1GeneProduct117519 (Entrez Gene)
MafGeneProduct54267 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Nfe2l2GeneProduct83619 (Entrez Gene)
Nqo1GeneProduct24314 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
SulforaphaneMetaboliteHMDB0005792 (HMDB)

Annotated Interactions

No annotated interactions
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