Estrogen signaling (Rattus norvegicus)

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Transcription Initiation Factors (TIFs)TIFsTFIIE+pActivationanti apoptosis+pRNA polymerase IITFIIATFIIBERE+pHistone Deacetylases (HDACs)TFIIDIKKsTFIIHTranslocationRNA Pol IIGene expression(anti apoptotic)MitochondrionHDACsNucleusInhibitionTATA Box bindingproteinGene expressionMAPKsTFIIFCrebbpPOLR2HGtf2e1JunGtf2a2HDAC5Akt1Taf7Mnat1Nfkb1Hdac8SrcSin3aERCC2Polr2jHdac7Polr2gHdac6EstradiolMapk14Gtf2bEsr1Gtf2h4PI3KPolr2aHdac1EstradiolSos1Hdac3Bcl2Gtf2f2GperCreb1Esr1FosTaf13Shc2Brca1Esr1Polr2bPolr2eTaf5Elk1Mapk9Mapk1Esr1Gngt1Polr2cIlkGnb1EstradiolHdac4Polr2iEstradiolEstradiolEsr1Taf9Ercc3EstradiolBcl2Map2k1CcnhHdac2N-CoREp300PrkacaTAF12IkbkbGSANP_001101058.1Ccnd1BrafTbpCdk7EstradiolGtf2h1LOC367858Gtf2h2Esr1Taf6Esr1TbpIkbkgGtf2h3Grb2EstradiolPolr2fEstradiolPOLR2KCreb1Sp1Gtf2e2Nfkb1Esr1Cyclic AMPEsr1Gtf2a2


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 90% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC
  2. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC
  3. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106948view13:41, 17 September 2019MaintBotHMDB identifier normalization
90718view20:21, 13 December 2016KhanspersModified title
69382view18:56, 8 July 2013MaintBotUpdated to 2013 gpml schema
58949view18:15, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
58517view20:00, 14 February 2013MaintBotOntology Term : 'estrogen signaling pathway' added !
58516view19:59, 14 February 2013MaintBotModified title
48265view21:58, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41697view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
34081view19:13, 9 December 2009MaintBotAutomatic update of empty xrefs
32301view13:17, 15 August 2009MaintBotFixed text labels
31879view12:40, 14 August 2009MaintBotFixed group labels
31330view20:22, 13 August 2009MaintBotFixed text labels
30933view00:38, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
Bcl2GeneProduct24224 (Entrez Gene)
BrafGeneProduct114486 (Entrez Gene)
Brca1GeneProduct497672 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
CcnhGeneProduct84389 (Entrez Gene)
Cdk7GeneProduct171150 (Entrez Gene)
Creb1GeneProduct81646 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
ERCC2GeneProduct308415 (Entrez Gene)
Elk1GeneProduct314436 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
Ercc3GeneProduct291703 (Entrez Gene)
Esr1GeneProduct24890 (Entrez Gene)
EstradiolMetaboliteHMDB0000151 (HMDB)
FosGeneProduct314322 (Entrez Gene)
GSAGeneProduct
Gnb1GeneProduct24400 (Entrez Gene)
Gngt1GeneProduct680149 (Entrez Gene)
GperGeneProduct171104 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Gtf2a2GeneProduct83828 (Entrez Gene)
Gtf2bGeneProduct81673 (Entrez Gene)
Gtf2e1GeneProduct303918 (Entrez Gene)
Gtf2e2GeneProduct306516 (Entrez Gene)
Gtf2f2GeneProduct81674 (Entrez Gene)
Gtf2h1GeneProduct361580 (Entrez Gene)
Gtf2h2GeneProduct294693 (Entrez Gene)
Gtf2h3GeneProduct288651 (Entrez Gene)
Gtf2h4GeneProduct294236 (Entrez Gene)
HDAC5GeneProduct84580 (Entrez Gene) HDAC5; histone deacetylase 5
Hdac1GeneProduct297893 (Entrez Gene) HDAC1; histone deacetylase 1
Hdac2GeneProduct84577 (Entrez Gene) HDAC2; histone deacetylase 2
Hdac3GeneProduct84578 (Entrez Gene) HDAC3; histone deacetylase 3
Hdac4GeneProduct363287 (Entrez Gene) HDAC4; histone deacetylase 4
Hdac6GeneProduct84581 (Entrez Gene) HDAC6; histone deacetylase 6
Hdac7GeneProduct84582 (Entrez Gene) HDAC7A; histone deacetylase 7
Hdac8GeneProduct363481 (Entrez Gene) HDAC8; histone deacetylase
IkbkbGeneProductENSRNOG00000019073 (Ensembl)
IkbkgGeneProductENSRNOG00000037237 (Ensembl)
IlkGeneProduct170922 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
LOC367858GeneProductENSRNOG00000016611 (Ensembl)
Map2k1GeneProductENSRNOG00000010176 (Ensembl)
Mapk14GeneProduct81649 (Entrez Gene)
Mapk1GeneProductENSRNOG00000001849 (Ensembl)
Mapk9GeneProduct50658 (Entrez Gene)
Mnat1GeneProduct266713 (Entrez Gene)
N-CoRGeneProduct
NP_001101058.1GeneProductENSRNOG00000022485 (Ensembl)
Nfkb1GeneProduct81736 (Entrez Gene)
PI3KGeneProduct
POLR2HGeneProduct498109 (Entrez Gene)
POLR2KGeneProduct309224 (Entrez Gene)
Polr2aGeneProduct363633 (Entrez Gene)
Polr2bGeneProduct289561 (Entrez Gene)
Polr2cGeneProduct361365 (Entrez Gene)
Polr2eGeneProduct690966 (Entrez Gene)
Polr2fGeneProduct83503 (Entrez Gene)
Polr2gGeneProduct117017 (Entrez Gene)
Polr2iGeneProduct292778 (Entrez Gene)
Polr2jGeneProduct288588 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
Shc2GeneProduct314612 (Entrez Gene)
Sin3aGeneProduct363067 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
TAF12GeneProduct682902 (Entrez Gene)
Taf13GeneProduct310784 (Entrez Gene)
Taf5GeneProduct294018 (Entrez Gene)
Taf6GeneProduct288533 (Entrez Gene)
Taf7GeneProduct307485 (Entrez Gene)
Taf9GeneProduct373541 (Entrez Gene)
TbpGeneProduct117526 (Entrez Gene)

Annotated Interactions

No annotated interactions
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