EBV LMP1 signaling (Rattus norvegicus)

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1, 4S32-PTES1S36-PS36-PUPPPS32-PTES2UUPPNfkb2Ccl5RelaIfnb1Mapk1IL8RelaIkbkgTnfSFC complexNP_001101390.1Pdlim7Ccl20Nfkb1NP_001101224.1NP_001101058.1Nfkb1TraddNfkb1RelaChukNP_001100528.1RelaIkbkbRelaTRAF1NP_001101390.1Hsp90aa1RelaNfkb1Nfkb2NP_001101771.1Irak1_predictedMapk8I-Kappa-BI-Kappa-B2, 3


based on science-slides...


This pathway was inferred from Homo sapiens pathway WP262(r29609) with a 86% conversion rate.

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Ontology Terms



  1. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC
  2. Lee JS, Lee JY, Son JW, Oh JH, Shin DM, Yuk JM, Song CH, Paik TH, Jo EK; ''Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis.''; Scand J Immunol, 2008 PubMed Europe PMC
  3. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC
  4. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC


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69373view18:55, 8 July 2013MaintBotUpdated to 2013 gpml schema
67171view10:16, 26 June 2013Christine ChichesterOntology Term : 'Epstein-Barr virus infection pathway' added !
58944view18:05, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41687view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
31878view12:40, 14 August 2009MaintBotFixed group labels
30931view00:37, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Ccl20GeneProductENSRNOG00000015992 (Ensembl)
Ccl5GeneProductENSRNOG00000010906 (Ensembl)
ChukGeneProduct309361 (Entrez Gene)
Hsp90aa1GeneProduct299331 (Entrez Gene)
Ifnb1GeneProductENSRNOG00000006268 (Ensembl)
IkbkbGeneProductENSRNOG00000019073 (Ensembl)
IkbkgGeneProductENSRNOG00000037237 (Ensembl)
Irak1_predictedGeneProductENSRNOG00000037263 (Ensembl)
Mapk1GeneProductENSRNOG00000001849 (Ensembl)
Mapk8GeneProductENSRNOG00000020155 (Ensembl)
NP_001100528.1GeneProductENSRNOG00000008441 (Ensembl)
NP_001101058.1GeneProductENSRNOG00000022485 (Ensembl)
NP_001101224.1GeneProductENSRNOG00000004639 (Ensembl)
NP_001101390.1GeneProductENSRNOG00000005724 (Ensembl)
NP_001101771.1GeneProductENSRNOG00000003278 (Ensembl)
Nfkb1GeneProductENSRNOG00000023258 (Ensembl)
Nfkb2GeneProductENSRNOG00000019311 (Ensembl)
Pdlim7GeneProductENSRNOG00000013653 (Ensembl)
RelaGeneProductENSRNOG00000030888 (Ensembl)
SFC complexGeneProduct
TnfGeneProductENSRNOG00000000837 (Ensembl)
TraddGeneProductENSRNOG00000015179 (Ensembl)

Annotated Interactions

No annotated interactions
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