Non-homologous end joining (Rattus norvegicus)

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Ligase VXrcc5Xrcc6Xrcc5Xrcc6NP_001101797.1LOC363251Rad50Xrcc5Xrcc6NP_001101797.1Ligase VXrcc6Xrcc6NP_001101797.1Mre11aNP_001101797.1Nhej1Xrcc5Xrcc4Xrcc6NP_001101797.1Xrcc5Xrcc5NP_001101797.1NP_001101797.1Xrcc6Xrcc6Xrcc4Nbs1 ?Xrcc5Xrcc5Xrcc6NP_001101797.1Xrcc5Xrcc6Xrcc5


(From Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.


This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 91% conversion rate.

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69423view19:02, 8 July 2013MaintBotUpdated to 2013 gpml schema
67514view11:19, 26 June 2013DdiglesOntology Term : 'non-homologous end joining pathway of double-strand break repair' added !
58965view18:38, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41746view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
35404view09:55, 12 February 2010MartijnVanIerselModified description
31877view12:40, 14 August 2009MaintBotFixed group labels
30927view00:36, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
LOC363251GeneProductENSRNOG00000018162 (Ensembl)
Ligase VGeneProduct
Mre11aGeneProductENSRNOG00000009506 (Ensembl)
NP_001101797.1GeneProductENSRNOG00000025028 (Ensembl)
Nbs1 ?GeneProduct
Nhej1GeneProduct363251 (Entrez Gene)
Rad50GeneProductENSRNOG00000033065 (Ensembl)
Xrcc4GeneProductENSRNOG00000029966 (Ensembl)
Xrcc5GeneProductENSRNOG00000016105 (Ensembl)
Xrcc6GeneProductENSRNOG00000006392 (Ensembl)

Annotated Interactions

No annotated interactions
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