Hypothetical Network for Drug Addiction (Mus musculus)

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1Strong depolarizationAMPARmGluRGonadotropins gene expression & secretionRegulation of actin cytoskeletonMAPK signaling pathwayRegulation of gap junctionGap junctionGnRH Signal pathwayLong-term potentiationLocal TranslationNeuroactive ligand-receptorinteractionNMDARCamk2bGrin2cGrm5Mapk3Zhx2Gria4NischGria3PrkacaGrin2bGria2Grin2aGria1Map2k2Cyclic AMPActa1PrkceGrin2dDrd2connexinGrm1GiCamk4Krit1Ppa1Terf2ipMapk1Creb1Adcy8Adcy1GsDrd4Drd1aCa++connexinMap2k1Adcy1Grin1PrkacaD-Glutamate


Adapted from figure 2 in Li et al..


This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 89% conversion rate.

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Ontology Terms



  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed


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69102view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67352view10:41, 26 June 2013Christine ChichesterOntology Term : 'substance dependence disease pathway' added !
48795view13:04, 19 June 2012MartijnVanIerseltiny tweak to regenerate SVG
41287view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
34386view22:49, 9 December 2009MaintBotAutomatic update of empty xrefs
32292view13:12, 15 August 2009MaintBotFixed text labels
31851view12:32, 14 August 2009MaintBotFixed group labels
31320view20:17, 13 August 2009MaintBotFixed text labels
30831view00:01, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Acta1GeneProduct11459 (Entrez Gene)
Adcy1GeneProduct432530 (Entrez Gene)
Adcy8GeneProduct11514 (Entrez Gene)
Ca++Metabolite29320 (ChEBI)
Camk2bGeneProduct12323 (Entrez Gene)
Camk4GeneProduct12326 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
Cyclic AMPMetabolite17489 (ChEBI)
D-GlutamateMetabolite15966 (ChEBI)
Drd1aGeneProduct13488 (Entrez Gene)
Drd2GeneProduct13489 (Entrez Gene)
Drd4GeneProduct13491 (Entrez Gene)
Gria1GeneProduct14799 (Entrez Gene)
Gria2GeneProduct14800 (Entrez Gene)
Gria3GeneProduct53623 (Entrez Gene)
Gria4GeneProduct14802 (Entrez Gene)
Grin1GeneProduct14810 (Entrez Gene)
Grin2aGeneProduct14811 (Entrez Gene)
Grin2bGeneProduct14812 (Entrez Gene)
Grin2cGeneProduct14813 (Entrez Gene)
Grin2dGeneProduct14814 (Entrez Gene)
Grm1GeneProduct14816 (Entrez Gene)
Grm5GeneProduct108071 (Entrez Gene)
GsGeneProduct109550 (Entrez Gene)
Krit1GeneProduct79264 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
NischGeneProduct64652 (Entrez Gene)
Ppa1GeneProduct67895 (Entrez Gene)
PrkacaGeneProduct18747 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene)
Terf2ipGeneProduct57321 (Entrez Gene)
Zhx2GeneProduct387609 (Entrez Gene)

Annotated Interactions

No annotated interactions
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