Non-homologous end joining (Mus musculus)

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Ligase VXrcc6PrkdcXrcc6PrkdcXrcc5Xrcc5Mre11aXrcc6Xrcc6Xrcc5Xrcc5PrkdcNbs1 ?Xrcc5Xrcc4PrkdcLigase VXrcc6Xrcc5Nhej1PrkdcPrkdcXrcc4Xrcc6Xrcc6Xrcc5Xrcc5Xrcc5Xrcc5Nhej1Rad50Xrcc6Xrcc6PrkdcPrkdcXrcc6


(From Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.


This pathway was inferred from Homo sapiens pathway WP438(r29612) with a 91% conversion rate.

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Ontology Terms



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69140view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67513view11:19, 26 June 2013DdiglesOntology Term : 'non-homologous end joining pathway of double-strand break repair' added !
59048view20:53, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41329view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35403view09:55, 12 February 2010MartijnVanIerselModified description
31847view12:31, 14 August 2009MaintBotFixed group labels
30822view23:58, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Ligase VGeneProduct
Mre11aGeneProductENSMUSG00000031928 (Ensembl)
Nbs1 ?GeneProduct
Nhej1GeneProduct75570 (Entrez Gene)
Nhej1GeneProductENSMUSG00000026162 (Ensembl)
PrkdcGeneProductENSMUSG00000022672 (Ensembl)
Rad50GeneProductENSMUSG00000020380 (Ensembl)
Xrcc4GeneProductENSMUSG00000021615 (Ensembl)
Xrcc5GeneProductENSMUSG00000026187 (Ensembl)
Xrcc6GeneProductENSMUSG00000022471 (Ensembl)

Annotated Interactions

No annotated interactions
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