Estrogen Signaling (Drosophila melanogaster)

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InhibitionTFIIHGene expressionTFIIAMitochondrionActivationTranslocationRNA Pol IIMAPKsRNA polymerase IITIFsGene expression(anti apoptotic)Histone Deacetylases (HDACs)TFIIF+p+pHDACsTranscription Initiation Factors (TIFs)+pNucleusanti apoptosisTATA Box bindingproteinTFIIBTFIIETFIIDIKKsEREGPR30RpII140HDAC6G-salpha60APOLR2KERTfIIEalphaTaf13CCND1SHCTbpBCL2rlTaf7SosBRCA1HDAC5e(y)1p38RelBCL2HDAC8Tfb1ERCycHTaf6EstradiolphlhayRpII15JNKskeyC-FOSEstradiolnejEstradiolSin3ARpd3PKB/AktCyclic AMPEstradiolTfb2ERRelXpdEstradiolN-CoRRpb7Taf12Ssl1TfIIA-STfIIA-STfb4Hdac3TbpRpII18PKACARpb5ERERRas85DEstradiolSP1HDAC2Rpb8ird5RpII33Cdk7ERHDAC7ATfIIBDsor1EstradiolJraPI3KGbeta13FTfIIFbetaTaf5Rpb11EstradiolEstradiolHDAC4CREBRpII215IlkERdrkMat1CBPERird5Src64BELKCREBGNGT1ERTfIIEbeta


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 62% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC
  2. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC
  3. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106089view11:59, 16 August 2019MaintBotHMDB identifier normalization
90715view20:20, 13 December 2016KhanspersModified title
88036view13:35, 25 July 2016SusanOntology Term : 'estrogen signaling pathway' added !
79410view20:39, 21 March 2015KhanspersModified title
79409view20:39, 21 March 2015Khanspersupdate schema
79408view20:39, 21 March 2015KhanspersReverted to version '00:19, 21 February 2013' by Khanspers
68727view22:02, 6 July 2013MaintBotUpdated to 2013 gpml schema
58866view00:19, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48289view23:52, 17 May 2012MaintBotAutomatic update of PubChem xrefs
40903view22:35, 1 March 2011MaintBotRemoved redundant pathway information and comments
34160view21:09, 9 December 2009MaintBotAutomatic update of empty xrefs
32276view13:06, 15 August 2009MaintBotFixed text labels
31812view12:21, 14 August 2009MaintBotFixed group labels
31304view20:11, 13 August 2009MaintBotFixed text labels
30771view23:18, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BCL2GeneProduct
BRCA1GeneProduct
C-FOSGeneProduct
CBPGeneProduct31669 (Entrez Gene)
CCND1GeneProduct
CREBGeneProduct
Cdk7GeneProduct31441 (Entrez Gene)
CycHGeneProduct40429 (Entrez Gene)
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
Dsor1GeneProductFBgn0010269 (Ensembl)
ELKGeneProduct37047 (Entrez Gene)
ERGeneProduct248548 (Entrez Gene)
EstradiolMetaboliteHMDB0000151 (HMDB)
G-salpha60AGeneProduct37805 (Entrez Gene)
GNGT1GeneProduct
GPR30GeneProduct
Gbeta13FGeneProduct32544 (Entrez Gene)
HDAC2GeneProductHDAC2; histone deacetylase 2
HDAC4GeneProduct32278 (Entrez Gene) HDAC4; histone deacetylase 4
HDAC5GeneProductHDAC5; histone deacetylase 5
HDAC6GeneProduct32461 (Entrez Gene) HDAC6; histone deacetylase 6
HDAC7AGeneProductHDAC7A; histone deacetylase 7
HDAC8GeneProductHDAC8; histone deacetylase
Hdac3GeneProduct44446 (Entrez Gene) HDAC3; histone deacetylase 3
IlkGeneProduct53573 (Entrez Gene)
JNKsGeneProduct
JraGeneProduct36057 (Entrez Gene)
Mat1GeneProduct36130 (Entrez Gene)
N-CoRGeneProduct
PI3KGeneProduct
PKACAGeneProduct
PKB/AktGeneProduct
POLR2KGeneProduct
Ras85DGeneProductFBgn0003205 (Ensembl)
RelGeneProduct41087 (Entrez Gene)
RpII140GeneProduct41721 (Entrez Gene)
RpII15GeneProduct41741 (Entrez Gene)
RpII18GeneProduct48312 (Entrez Gene)
RpII215GeneProduct32100 (Entrez Gene)
RpII33GeneProduct34796 (Entrez Gene)
Rpb11GeneProduct35043 (Entrez Gene)
Rpb5GeneProduct36160 (Entrez Gene)
Rpb7GeneProduct261631 (Entrez Gene)
Rpb8GeneProduct40415 (Entrez Gene)
Rpd3GeneProduct38565 (Entrez Gene) HDAC1; histone deacetylase 1
SHCGeneProduct44052 (Entrez Gene)
SP1GeneProduct31913 (Entrez Gene)
Sin3AGeneProduct36382 (Entrez Gene)
SosGeneProduct34790 (Entrez Gene)
Src64BGeneProduct48973 (Entrez Gene)
Ssl1GeneProduct40509 (Entrez Gene)
Taf12GeneProduct41406 (Entrez Gene)
Taf13GeneProduct35297 (Entrez Gene)
Taf5GeneProduct47900 (Entrez Gene)
Taf6GeneProduct40134 (Entrez Gene)
Taf7GeneProduct40934 (Entrez Gene)
TbpGeneProduct37476 (Entrez Gene)
TfIIA-SGeneProduct42822 (Entrez Gene)
TfIIBGeneProduct34430 (Entrez Gene)
TfIIEalphaGeneProduct39313 (Entrez Gene)
TfIIEbetaGeneProduct38527 (Entrez Gene)
TfIIFbetaGeneProduct41290 (Entrez Gene)
Tfb1GeneProduct36598 (Entrez Gene)
Tfb2GeneProduct39688 (Entrez Gene)
Tfb4GeneProduct33294 (Entrez Gene)
XpdGeneProduct37414 (Entrez Gene)
drkGeneProduct36497 (Entrez Gene)
e(y)1GeneProduct32762 (Entrez Gene)
hayGeneProduct39202 (Entrez Gene)
ird5GeneProductFBgn0024222 (Ensembl)
keyGeneProductFBgn0041205 (Ensembl)
nejGeneProduct43856 (Entrez Gene)
p38GeneProduct
phlGeneProduct31221 (Entrez Gene)
rlGeneProductFBgn0003256 (Ensembl)

Annotated Interactions

No annotated interactions
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