Cell cycle (Canis familiaris)

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1e+u-pp16,15,18,19+pDNAp21Securinpathway+pTranscription Factor E2FGrowth Factor withdrawalmediated+p+p+p(Start)G2e+pMeDNA biosynthesisMCM (Mini-ChromosomeMaintenance) complexCondensin+peeS-phase proteinsUbiquitinSeparinMAPKApoptosis+p+pHDAC+pG1DNAGrowth Factor+p+p+u+p+pproteolysisDNA damage checkpointsignalingSR-point+up27,57+pHistone Deacetylases+u-pORC (OriginRecognition complex)+u+p+pMPEG1RBL1ORC5LCCNA2CCNA2CDK4CHEK2APC/CCDK2CDKN1BPCNARB1E2FSKP2BUB1BLOC478040MCM6CCNA1CDC6CCNB2BUB3ARFATMMCM514-3-3SCFORCLOC486589GSK3BSMAD3LOC480907MCM7PTTG1PTTG2ATRUBE2FMAD2L1SMAD4CCNE2CDK2E2F1E2F3CDC25BSMC1ACCND3CDC2PRKDCDBF4ORC3LESPL1LOC607662CDK6SKP2MDM2MCM2CCNB3YWHAGORC4LTP53CCNB1CDC45LCDKN1ABUB1CCNE1MAD1L1CDC7CDC14ACDH1E2F2ORC2LPKMYT1WEE1LOC487309LOC475035TGFB1CCNHCDC25ARB1CDC2GeneProductCDC14BMCM3MAD2L2ABL1CDK2ORC6LLOC490941CCND2RBL1E2F6TFDP1E2F4GADD45ASCFMCM4CCNA1CDKN2AE2F5MENPTTG3MCMTBC1D8RB1CDC20APC/CLOC480957CDC25CORC1LEP300CHEK1PLK1


(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 80% conversion rate.

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Ontology Terms



  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia


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111030view21:36, 1 July 2020L DupuisConverted interactions to graphical lines in outlines
86993view14:38, 15 July 2016MkutmonOntology Term : 'cell cycle pathway' added !
71456view19:16, 17 October 2013MaintBotAutomated update of data sources
68515view21:59, 5 July 2013MaintBotUpdated to 2013 gpml schema
62716view03:16, 2 May 2013MaintBotUpdated UniProt data source
40668view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
35372view09:16, 12 February 2010MartijnVanIerselModified description
33960view18:24, 9 December 2009MaintBotAutomatic update of empty xrefs
32275view13:06, 15 August 2009MaintBotFixed text labels
31810view12:21, 14 August 2009MaintBotFixed group labels
31303view20:11, 13 August 2009MaintBotFixed text labels
30769view23:15, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ABL1GeneProduct491292 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:
ATMGeneProduct479450 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:]
ATRGeneProduct477101 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
BUB1GeneProductBUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProduct608350 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3GeneProduct477857 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1GeneProduct477302 (Entrez Gene) CCNA1; cyclin A1
CCNA2GeneProduct483845 (Entrez Gene) CCNA2; cyclin A2
CCNB1GeneProductCCNB1; cyclin B1
CCNB2GeneProduct478324 (Entrez Gene) CCNB2; cyclin B2
CCNB3GeneProduct449494 (Entrez Gene) CCNB3; cyclin B
CCND2GeneProduct611782 (Entrez Gene) CCND2; cyclin D2
CCND3GeneProduct608847 (Entrez Gene) CCND3; cyclin D3
CCNE1GeneProduct484610 (Entrez Gene) CCNE1; cyclin E
CCNE2GeneProduct487057 (Entrez Gene) CCNE2; cyclin E
CCNHGeneProduct479156 (Entrez Gene) CCNH; cyclin H
CDC14AGeneProduct479926 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CDC14BGeneProduct476294 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC20GeneProduct482534 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC2GeneProduct488997 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDC25AGeneProduct484780 (Entrez Gene) CDC25A; cell division cycle 25A [EC:]
CDC25BGeneProduct485790 (Entrez Gene) CDC25B; cell division cycle 25B [EC:]
CDC25CGeneProduct610456 (Entrez Gene) CDC25C; cell division cycle 25C [EC:]
CDC45LGeneProduct486421 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProduct480527 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProduct479955 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDH1GeneProduct442858 (Entrez Gene)
CDK2GeneProduct606931 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProduct481131 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProduct609920 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProduct474890 (Entrez Gene)
CDKN1BGeneProduct403429 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct100271861 (Entrez Gene)
CHEK1GeneProduct609767 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHEK2GeneProduct486338 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
DBF4GeneProduct475219 (Entrez Gene) ASK; activator of S phase kinas
E2F1GeneProduct485839 (Entrez Gene) E2F1; E2F transcription factor 1
E2F2GeneProductE2F2; E2F transcription factor 2
E2F3GeneProduct488239 (Entrez Gene) E2F3; E2F transcription factor 3
E2F4GeneProduct611243 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2F5GeneProduct611103 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2F6GeneProduct609996 (Entrez Gene) E2F6; E2F transcription factor 6
EP300GeneProductEP300; E1A binding protein p300
ESPL1GeneProduct607879 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
GSK3BGeneProduct478575 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:]
LOC475035GeneProduct475035 (Entrez Gene) HDAC2; histone deacetylase 2
LOC478040GeneProduct478040 (Entrez Gene) HDAC3; histone deacetylase 3
LOC480907GeneProduct480907 (Entrez Gene) HDAC6; histone deacetylase 6
LOC480957GeneProduct480957 (Entrez Gene) HDAC8; histone deacetylase
LOC486589GeneProduct486589 (Entrez Gene) HDAC7A; histone deacetylase 7
LOC487309GeneProduct487309 (Entrez Gene) HDAC1; histone deacetylase 1
LOC490941GeneProduct490941 (Entrez Gene) HDAC5; histone deacetylase 5
LOC607662GeneProduct607662 (Entrez Gene) HDAC4; histone deacetylase 4
MAD1L1GeneProduct609673 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L1GeneProduct476070 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2GeneProduct487443 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCM2GeneProduct484622 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MCM3GeneProduct481839 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
MCM4GeneProduct477871 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
MCM5GeneProduct610519 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
MCM6GeneProduct476131 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
MCM7GeneProduct479737 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MDM2GeneProduct403693 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MPEG1GeneProduct475960 (Entrez Gene)
ORC1LGeneProduct475351 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
ORC2LGeneProduct478868 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
ORC3LGeneProduct474991 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
ORC4LGeneProduct476141 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
ORC5LGeneProduct609937 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
ORC6LGeneProduct482492 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PCNAGeneProduct477166 (Entrez Gene) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProduct490050 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProduct489971 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProduct474176 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:]
PTTG1GeneProduct479307 (Entrez Gene) PTTG1; pituitary tumor-transforming
PTTG2GeneProductPTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProduct476915 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
RBL1GeneProduct477221 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
SKP2GeneProduct489228 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
SMAD3GeneProduct610902 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProduct476196 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1AGeneProduct480928 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8GeneProduct474551 (Entrez Gene)
TFDP1GeneProduct607720 (Entrez Gene) TFDP1; transcription factor Dp-1
TGFB1GeneProduct403998 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
UBE2FGeneProduct477421 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
WEE1GeneProduct476847 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:]
YWHAGGeneProduct489818 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
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