S1P receptor signal transduction (Canis familiaris)

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Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation.


GenMAPP notes 
Representation of Figure 2. from T. Hla, et al. 2001, Science, 294, pg. 1877
This pathway was inferred from Homo sapiens pathway WP26(r20731) with a 96% conversion rate.

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Ontology Terms



  1. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ; ''Lysophospholipids--receptor revelations.''; Science, 2001 PubMed Europe PMC Scholia


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118659view15:18, 31 May 2021DeSlOntology Term : 'signaling pathway' added !
118658view15:18, 31 May 2021DeSlOntology Term : 'G protein mediated signaling pathway' added !
118657view15:17, 31 May 2021DeSlConnected last unconnected line
118656view15:16, 31 May 2021DeSlAdded description from WP26
118655view15:15, 31 May 2021DeSlCleaned up comments in description
118654view15:14, 31 May 2021DeSlConverted top complex to group, according to lit. ref.
118653view15:12, 31 May 2021DeSlUpdated title according to WP26
118652view15:12, 31 May 2021DeSlRedrawn, structured, converted complexes to groups, as in original (WP26)
87662view08:55, 25 July 2016LindarieswijkOntology Term : 'sphingosine 1-phosphate signaling pathway' added !
68536view22:21, 5 July 2013MaintBotUpdated to 2013 gpml schema
40692view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
31808view12:20, 14 August 2009MaintBotFixed group labels
30767view23:14, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
AKT2GeneProduct449021 (Entrez Gene)
AKT3GeneProduct442964 (Entrez Gene)
ASAH1GeneProduct482897 (Entrez Gene)
GNAI1GeneProduct478227 (Entrez Gene)
GNAI2GeneProduct442957 (Entrez Gene)
GNAI3GeneProduct611810 (Entrez Gene)
MAPK12GeneProduct607023 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK4GeneProduct491690 (Entrez Gene)
MAPK6GeneProduct478311 (Entrez Gene)
MAPK7GeneProduct489532 (Entrez Gene)
PIK3C2BGeneProduct478938 (Entrez Gene)
PLCB1GeneProduct485773 (Entrez Gene)
PLCB2GeneProduct487491 (Entrez Gene)
PLCB3GeneProduct476034 (Entrez Gene)
RACGAP1GeneProduct486549 (Entrez Gene)
S1PR1GeneProduct490138 (Entrez Gene)
S1PR2GeneProduct484959 (Entrez Gene)
S1PR3GeneProduct484199 (Entrez Gene)
S1PR5GeneProduct610828 (Entrez Gene)
SPHK1GeneProduct483329 (Entrez Gene)
SPHK2GeneProduct484401 (Entrez Gene)

Annotated Interactions

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