G1 to S cell cycle control (Canis familiaris)

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1origin recognition complexDNA replicationCell cycle DNA replication genesbpG2 Phase-M phasepDegradationcakCheckpointE2fTTTCC/GCGCRbCyclin Esphosphorylation of proteinsinvolved in G1/S transitionG1/S transition CyclinDependent KinasesG1/S transition PhasebuCyclinDCyclin DsG1 PhaseeG1/S Cell CyclepDNA polymerasespinactiveG1 CyclinDependant Cyclasesppdp1euuORC1CCND2CDKN1CPRIM2ORC2TFDP2ORC5CREB1TFDP1MYT1CDK7MDM2RPA1CDKN1AMCM3ATMCDKN1BCDC25AWEE1MCM4ATF6BCDKE2F4CDK2RB1CDKE2F6CDKN2APOLA2RB1CDK6CDKN2CCCNB1CREB3L4E2F5CREB3CDK1POLETFDP1MCM6PRIM1ORC4ORC6CCNE1E2F1MCM2PCNAMYCCCNE1CDK4CDC45RPA3RPA2E2F2CCNHCDKN2BCDKN2DCCNG2CCND3CREB3L3CDK6MCM7GADD45AE2fCCNE2MCM5TP53ORC3CCNE1CCND1TP53E2F3E2fCDK7CDK4MNAT1POLE2CREB3L1RB1CDK2RBL1CCNA1CdKCyclinDCdK


Description

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP45 (r95145) with a 90.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95748view13:54, 19 January 2018MkutmonHomology conversion update
68574view23:00, 5 July 2013MaintBotUpdated to 2013 gpml schema
67266view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
48155view18:50, 9 May 2012MaintBotUpdating from human to fix xrefs
40732view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35826view22:00, 17 February 2010KhanspersModified description
34010view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
32271view13:05, 15 August 2009MaintBotFixed text labels
31805view12:19, 14 August 2009MaintBotFixed group labels
31299view20:10, 13 August 2009MaintBotFixed text labels
30764view23:13, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF6BGeneProductENSCAFG00000000761 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1388
ATMGeneProductENSCAFG00000014454 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:472
CCNA1GeneProductENSCAFG00000006189 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8900
CCNB1GeneProductENSCAFG00000009965 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:891
CCND1GeneProductENSCAFG00000010700 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:595
CCND2GeneProductENSCAFG00000015381 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:894
CCND3GeneProductENSCAFG00000001618 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:896
CCNE1GeneProductENSCAFG00000007614 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:898
CCNE2GeneProductENSCAFG00000009408 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9134
CCNG2GeneProductENSCAFG00000008685 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:901
CCNHGeneProductENSCAFG00000008374 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:902
CDC25AGeneProductENSCAFG00000012919 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:993
CDC45GeneProductENSCAFG00000014571 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8318
CDKGeneProduct
CDK1GeneProductENSCAFG00000012904 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:983
CDK2GeneProductENSCAFG00000000082 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1017
CDK4GeneProductENSCAFG00000000280 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1019
CDK6GeneProductENSCAFG00000001998 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1021
CDK7GeneProductENSCAFG00000007748 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1022
CDKN1AGeneProductENSCAFG00000029853 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1026
CDKN1BGeneProductENSCAFG00000013244 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1027
CDKN1CGeneProductNo homologues found for original id L:1028
CDKN2AGeneProductNo homologues found for original id L:1029
CDKN2BGeneProductENSCAFG00000001680 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1030
CDKN2CGeneProductENSCAFG00000028905 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1031
CDKN2DGeneProductNo homologues found for original id L:1032
CREB1GeneProductENSCAFG00000013510 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1385
CREB3GeneProductENSCAFG00000002203 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10488
CREB3L1GeneProductENSCAFG00000009282 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:90993
CREB3L3GeneProductENSCAFG00000019126 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:84699
CREB3L4GeneProductENSCAFG00000017395 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:148327
E2F1GeneProductENSCAFG00000007435 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1869
E2F2GeneProductENSCAFG00000013273 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1870
E2F3GeneProductENSCAFG00000031036 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1871
E2F4GeneProductENSCAFG00000020375 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1874
E2F5GeneProductENSCAFG00000008628 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1875
E2F6GeneProductENSCAFG00000023799 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1876
E2fGeneProduct
GADD45AGeneProductENSCAFG00000029474 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1647
MCM2GeneProductENSCAFG00000004052 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4171
MCM3GeneProductENSCAFG00000002196 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4172
MCM4GeneProductENSCAFG00000006598 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4173
MCM5GeneProductENSCAFG00000001709 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4174
MCM6GeneProductENSCAFG00000005143 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4175
MCM7GeneProductENSCAFG00000014748 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4176
MDM2GeneProductENSCAFG00000000418 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4193
MNAT1GeneProductENSCAFG00000015639 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4331
MYCGeneProductENSCAFG00000001086 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4609
MYT1GeneProductENSCAFG00000013222 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4661
ORC1GeneProductENSCAFG00000003744 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4998
ORC2GeneProductENSCAFG00000012060 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4999
ORC3GeneProductENSCAFG00000003080 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23595
ORC4GeneProductENSCAFG00000005522 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5000
ORC5GeneProductENSCAFG00000004146 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5001
ORC6GeneProductENSCAFG00000003683 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23594
PCNAGeneProductENSCAFG00000006030 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5111
POLA2GeneProductENSCAFG00000013677 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23649
POLE2GeneProductNo homologues found for original id L:5427
POLEGeneProductENSCAFG00000006215 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5426
PRIM1GeneProductENSCAFG00000000142 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5557
PRIM2GeneProductENSCAFG00000023267 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5558
RB1GeneProductENSCAFG00000004436 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5925
RBL1GeneProductENSCAFG00000008696 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5933
RPA1GeneProductENSCAFG00000019249 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6117
RPA2GeneProductENSCAFG00000011979 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6118
RPA3GeneProductENSCAFG00000000261 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6119
TFDP1GeneProductENSCAFG00000006384 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7027
TFDP2GeneProductENSCAFG00000007742 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7029
TP53GeneProductENSCAFG00000016714 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7157
WEE1GeneProductENSCAFG00000007416 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7465

Annotated Interactions

No annotated interactions
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