Monoamine GPCRs (Canis familiaris)

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Gs PathwayAdrenergicReceptorsDopamineReceptorsMuscarinicAcetylcholine ReceptorsGs PathwayGq/G11 PathwaySerotoninReceptorsHistamineReceptorsGi/Go PathwayDRD3ADRA1BHTR7HRH1HTR5BHTR1BCHRM4NorepinephrineHTR1DHTR1ACHRM1DRD4HTR1EADRA1DADRA1AHistamineHTR6MuscarineCHRM2DopamineDRD2ADRA2BHRH2DRD1EpinephrineADRB2SerotoninHTR2AHTR2BADRA2CHTR2CADRB3CHRM3CHRM5DRD5ADRB1Acetylcholine HTR4HTR5AHTR1FADRA2A


Description

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: Wikipedia


Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. Monoamine neurotransmitters

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP58(r20799) with a 72% conversion rate.

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
106064view11:57, 16 August 2019MaintBotHMDB identifier normalization
98236view12:36, 14 August 2018EgonwReplace a PubChem SID with a PubChem CID.
96089view19:08, 15 February 2018KhanspersModified description
87856view11:54, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
87855view11:53, 25 July 2016ElisaOntology Term : 'G protein mediated signaling pathway' added !
74179view15:43, 2 April 2014EgonwUpdated the PubChem-substance data source.
71458view19:16, 17 October 2013MaintBotAutomated update of data sources
68523view22:07, 5 July 2013MaintBotUpdated to 2013 gpml schema
40677view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
33967view18:27, 9 December 2009MaintBotAutomatic update of empty xrefs
32270view13:04, 15 August 2009MaintBotFixed text labels
31803view12:19, 14 August 2009MaintBotFixed group labels
31298view20:10, 13 August 2009MaintBotFixed text labels
30762view23:12, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADRA1AGeneProduct403866 (Entrez Gene)
ADRA1BGeneProduct403962 (Entrez Gene)
ADRA1DGeneProduct552897 (Entrez Gene)
ADRA2AGeneProduct486888 (Entrez Gene)
ADRA2BGeneProduct611658 (Entrez Gene)
ADRA2CGeneProduct488793 (Entrez Gene)
ADRB1GeneProduct493972 (Entrez Gene)
ADRB2GeneProduct403910 (Entrez Gene)
ADRB3GeneProduct442979 (Entrez Gene)
Acetylcholine MetaboliteHMDB0000895 (HMDB)
CHRM1GeneProduct483776 (Entrez Gene)
CHRM2GeneProduct403858 (Entrez Gene)
CHRM3GeneProduct403827 (Entrez Gene)
CHRM4GeneProduct611314 (Entrez Gene)
CHRM5GeneProduct487472 (Entrez Gene)
DRD1GeneProduct489110 (Entrez Gene)
DRD2GeneProduct403701 (Entrez Gene)
DRD3GeneProduct487984 (Entrez Gene)
DRD4GeneProduct448805 (Entrez Gene)
DRD5GeneProduct488824 (Entrez Gene)
DopamineMetabolite
EpinephrineMetaboliteHMDB0000068 (HMDB)
HRH1GeneProduct403813 (Entrez Gene)
HRH2GeneProduct403812 (Entrez Gene)
HTR1AGeneProduct487230 (Entrez Gene)
HTR1BGeneProduct403741 (Entrez Gene)
HTR1DGeneProduct403963 (Entrez Gene)
HTR1EGeneProduct481907 (Entrez Gene)
HTR1FGeneProduct
HTR2AGeneProduct403882 (Entrez Gene)
HTR2BGeneProduct403881 (Entrez Gene)
HTR2CGeneProduct450240 (Entrez Gene)
HTR4GeneProduct489198 (Entrez Gene)
HTR5AGeneProduct482814 (Entrez Gene)
HTR5BGeneProduct
HTR6GeneProduct487402 (Entrez Gene)
HTR7GeneProduct477762 (Entrez Gene)
HistamineMetabolite
MuscarineMetabolite9308 (PubChem-compound)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
SerotoninMetabolite

Annotated Interactions

No annotated interactions
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