Integrin-mediated cell adhesion (Canis familiaris)

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Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP185(r21067) with a 84% conversion rate.

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Ontology Terms



  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia


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71477view19:18, 17 October 2013MaintBotAutomated update of data sources
68570view22:55, 5 July 2013MaintBotUpdated to 2013 gpml schema
67400view10:56, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
62725view03:18, 2 May 2013MaintBotUpdated UniProt data source
40728view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35600view15:45, 12 February 2010ThomasModified description
35593view15:41, 12 February 2010Thomasadded literature
34007view18:40, 9 December 2009MaintBotAutomatic update of empty xrefs
31795view12:16, 14 August 2009MaintBotFixed group labels
30754view23:08, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2GeneProduct449021 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
AKT3GeneProduct442964 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
ARAFGeneProduct491857 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
ARHGEF7GeneProduct485552 (Entrez Gene) ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
BCAR1GeneProduct479648 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
BRAFGeneProduct475526 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10GeneProduct607311 (Entrez Gene) CAPN10; calpain 10 [EC:
CAPN11GeneProduct609624 (Entrez Gene) CAPN11; calpain 11 [EC:]
CAPN1GeneProduct483745 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:]
CAPN2GeneProduct480118 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:]
CAPN3GeneProduct487518 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:]
CAPN5GeneProduct485175 (Entrez Gene) CAPN5; calpain
CAPN6GeneProduct492068 (Entrez Gene) CAPN6; calpain 6 [EC:]
CAPN7GeneProduct477062 (Entrez Gene) CAPN7; calpain 7 [EC:
CAPN9GeneProduct608044 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:
CAPNS1GeneProduct611746 (Entrez Gene) CAPNS1; calpain small subunit 1 [EC:]
CAV1GeneProduct403980 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
CAV2GeneProduct475294 (Entrez Gene) CAV2; caveolin 2
CAV3GeneProduct484671 (Entrez Gene) CAV3; caveolin 3
CDC42GeneProduct607535 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
CRKGeneProductCRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CSKGeneProduct487649 (Entrez Gene) CSK; c-src tyrosine kinase [EC:]
DOCK1GeneProduct486934 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
FYNGeneProduct475032 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
GIT2GeneProduct477520 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
GRB2GeneProduct483312 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
ILKGeneProduct476836 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10GeneProduct608287 (Entrez Gene)
ITGA11GeneProduct478353 (Entrez Gene)
ITGA1GeneProduct489210 (Entrez Gene)
ITGA2GeneProduct489208 (Entrez Gene)
ITGA2BGeneProduct403789 (Entrez Gene)
ITGA4GeneProduct488429 (Entrez Gene)
ITGA5GeneProduct486493 (Entrez Gene)
ITGA6GeneProduct478800 (Entrez Gene)
ITGA7GeneProduct481097 (Entrez Gene)
ITGA8GeneProduct487119 (Entrez Gene)
ITGA9GeneProduct477021 (Entrez Gene)
ITGADGeneProduct607096 (Entrez Gene)
ITGAEGeneProduct480659 (Entrez Gene)
ITGALGeneProduct489905 (Entrez Gene)
ITGAMGeneProduct489928 (Entrez Gene)
ITGAVGeneProduct488437 (Entrez Gene)
ITGAXGeneProduct489929 (Entrez Gene)
ITGB1GeneProduct477956 (Entrez Gene)
ITGB2GeneProduct403770 (Entrez Gene)
ITGB3GeneProduct403788 (Entrez Gene)
ITGB4GeneProduct483318 (Entrez Gene)
ITGB5GeneProduct608977 (Entrez Gene)
ITGB6GeneProduct488368 (Entrez Gene)
ITGB7GeneProduct477598 (Entrez Gene)
ITGB8GeneProduct475253 (Entrez Gene)
LOC476352GeneProduct476352 (Entrez Gene) SHC3; neuronal Sh
MAP2K1GeneProduct478347 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2GeneProduct611939 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
MAP2K3GeneProduct489547 (Entrez Gene) MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5GeneProductMAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6GeneProduct480454 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK10GeneProduct478464 (Entrez Gene)
MAPK12GeneProduct607023 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MAPK1GeneProduct477575 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK4GeneProduct491690 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK6GeneProduct478311 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAPK7GeneProduct489532 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2GeneProduct477187 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
PAK1GeneProduct607885 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
PAK2GeneProduct612814 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3GeneProduct492067 (Entrez Gene) PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4GeneProduct484513 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6GeneProduct487490 (Entrez Gene) PAK6; p21(CDKN1A)-activated kinase
PDPK1GeneProduct479875 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
PIK3R2GeneProduct609956 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
PTK2GeneProduct475108 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
PXNGeneProduct486299 (Entrez Gene) PXN; paxillin
RAC1GeneProduct403955 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2GeneProduct481271 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3GeneProductRAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAF1GeneProduct484648 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1AGeneProduct483225 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAP1BGeneProduct608981 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RAPGEF1GeneProduct491286 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RHOGeneProduct493763 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
ROCK1GeneProduct480181 (Entrez Gene) ROCK1; Rho-associated coiled-coil containing protein kinase
ROCK2GeneProduct482970 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
SEPP1GeneProduct479346 (Entrez Gene) SEPP1; selenoprotein P plasma
SHC1GeneProduct490439 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SORBS1GeneProductSH3D5; SH3-domain protein 5 (ponsin
SOS1GeneProduct483042 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SRCGeneProduct485864 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
TLN1GeneProduct474759 (Entrez Gene) TLN1; talin 1
TNS1GeneProduct488519 (Entrez Gene) TNS; tensi
VASPGeneProduct403936 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
VAV2GeneProduct608060 (Entrez Gene) VAV2; vav 2 oncogene
VAV3GeneProduct479921 (Entrez Gene) VAV3; vav 3 oncogene
VCLGeneProductVCL; vinculin
ZYXGeneProduct482736 (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions
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