Nuclear Receptors (Canis familiaris)

From WikiPathways

Jump to: navigation, search
1Progesterone ReceptorReceptorOrphan ReceptorNR1 SUPERFAMILYNR0 SUPERFAMILYNR2 SUPERFAMILYNuclear receptor TLXSteroidogenic ReceptorGlucocorticoid ReceptorHepatocyte Nuclear FactorCoup Transcription FactorSteroid Hormone ReceptorPeroxisome ProliferatorNR3 SUPERFAMILYRetinoic Acid ReceptorRetinoic Acid Receptor RXRThyroid ReceptorActivated ReceptorNuclear Receptor RORAndrogen ReceptorOrphan ReceptorNR5 SUPERFAMILYOrphan Nuclear ReceptorOrphan NuclearOxysterols ReceptorNR4 SUPERFAMILYEstrogen ReceptorVitamin D3 ReceptorNR3C1NR1H2RARGRARBNR2C2THRBRORCRXRAESR2HNF4ANR2F1ESRRANR5A1VDRPGRPPARGNR4A1NR1I2NR4A2NR2F2NR1D2RXRBNR2F6RARGRXRGPPARANR5A2PPARDROR1ARPPARGNR0B1RARAESRRBESR1THRBNR1H3NR1I3THRARORANR2E1


Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia (wikipedia:Nuclear_receptor)


This pathway was inferred from Homo sapiens pathway WP170(r21037) with a 100% conversion rate.

Quality Tags

Ontology Terms



  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia


View all...
89863view12:34, 6 October 2016MkutmonModified description
69969view21:12, 11 July 2013MaintBot
69968view21:11, 11 July 2013MaintBotupdating to 2013 schema
67529view11:21, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
40738view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35774view00:12, 13 February 2010AlexanderPico
31794view12:16, 14 August 2009MaintBotFixed group labels
30753view23:08, 29 July 2009MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
ARGeneProduct403588 (Entrez Gene)
ESR1GeneProduct403640 (Entrez Gene)
ESR2GeneProduct403639 (Entrez Gene)
ESRRAGeneProduct403169 (Entrez Gene)
ESRRBGeneProduct490798 (Entrez Gene)
HNF4AGeneProduct485884 (Entrez Gene)
NR0B1GeneProduct491804 (Entrez Gene)
NR1D2GeneProduct485643 (Entrez Gene)
NR1H2GeneProduct610057 (Entrez Gene)
NR1H3GeneProduct483625 (Entrez Gene)
NR1I2GeneProduct403482 (Entrez Gene)
NR1I3GeneProduct488653 (Entrez Gene)
NR2C2GeneProduct484641 (Entrez Gene)
NR2E1GeneProduct475017 (Entrez Gene)
NR2F1GeneProduct488908 (Entrez Gene)
NR2F2GeneProduct479026 (Entrez Gene)
NR2F6GeneProduct609720 (Entrez Gene)
NR3C1GeneProduct478047 (Entrez Gene)
NR4A1GeneProduct403897 (Entrez Gene)
NR4A2GeneProduct478754 (Entrez Gene)
NR5A1GeneProduct609642 (Entrez Gene)
NR5A2GeneProduct490252 (Entrez Gene)
PGRGeneProduct403621 (Entrez Gene)
PPARAGeneProduct403654 (Entrez Gene)
PPARDGeneProduct481756 (Entrez Gene)
PPARGGeneProduct403606 (Entrez Gene)
RARAGeneProduct480526 (Entrez Gene)
RARBGeneProduct477045 (Entrez Gene)
RARGGeneProduct486508 (Entrez Gene)
ROR1GeneProduct489557 (Entrez Gene)
RORAGeneProduct478328 (Entrez Gene)
RORCGeneProduct483205 (Entrez Gene)
RXRAGeneProduct491278 (Entrez Gene)
RXRBGeneProduct481735 (Entrez Gene)
RXRGGeneProduct478989 (Entrez Gene)
THRAGeneProduct403601 (Entrez Gene)
THRBGeneProduct403599 (Entrez Gene)
VDRGeneProduct486588 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools