Endochondral Ossification (Canis familiaris)

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1, 2CartilageWNT signalingcanonical / non-canonicalDyingFull differentiationMineralisationBMPsOsteoblasticdifferentiationGsProliferationRemoval of extracellular matrixand invasion by bone cellsVascular invastionHypertrophyChondrocyte proliferationRemoval of cartilage matrixCathepsinsand Calpains?Chondrocyte (pre)hypertrophyBoneintegrinsChondrocyte deathFGFR3ENPP1SERPINH1PLAUCAB39LOC607662RUNX2PTCHCOL2A1BMP7CarminerinCTSL2FrzB-1NKX3-2KIF3ATriiodothyroninecAMPIGF1RRUNX2MGPADAMTS4MEF2CThyroid hormoneAKT1FGF18GLI3CHST11PRKACAPLATMMP13SOX5TIMP3SOX9ACANSLC38A2ADAMTS1IGF1TGFB1FGF2IGF2DDR2RUNX3MMP9BMPR1ATGFB1PTHLHHMGCS1PTH1RVEGFAGrowth hormoneCALM1STAT1THRASOX6THRALOC475245COL10A1ALPLIFT88PTCH1TNAPBMP6GHRCDKN1CRUNX2ADAMTS5PTHFGFR1IHHSPP1Thyroid hormoneSTAT5BTGFB2Oxygen


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 79% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107091view14:17, 17 September 2019MaintBotChEBI identifier normalization
106059view11:57, 16 August 2019MaintBotHMDB identifier normalization
87972view13:17, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72215view12:54, 27 October 2013EgonwFixed the ChEBI database name.
72175view22:18, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
68505view21:49, 5 July 2013MaintBotUpdated to 2013 gpml schema
40656view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33948view18:20, 9 December 2009MaintBotAutomatic update of empty xrefs
32264view13:02, 15 August 2009MaintBotFixed text labels
31791view12:15, 14 August 2009MaintBotFixed group labels
31292view20:07, 13 August 2009MaintBotFixed text labels
30750view23:07, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACANGeneProduct403828 (Entrez Gene)
ADAMTS1GeneProduct
ADAMTS4GeneProduct488651 (Entrez Gene)
ADAMTS5GeneProduct487713 (Entrez Gene)
AKT1GeneProduct490878 (Entrez Gene)
ALPLGeneProduct403548 (Entrez Gene)
BMP6GeneProduct
BMP7GeneProduct477270 (Entrez Gene)
BMPR1AGeneProduct489077 (Entrez Gene)
CAB39GeneProduct477403 (Entrez Gene)
CALM1GeneProduct480416 (Entrez Gene)
CDKN1CGeneProduct
CHST11GeneProduct481299 (Entrez Gene)
COL10A1GeneProduct611118 (Entrez Gene)
COL2A1GeneProduct403826 (Entrez Gene)
CTSL2GeneProduct403708 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
CarminerinGeneProduct
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
DDR2GeneProduct478987 (Entrez Gene)
ENPP1GeneProduct476153 (Entrez Gene)
FGF18GeneProduct611641 (Entrez Gene)
FGF2GeneProduct
FGFR1GeneProduct475582 (Entrez Gene)
FGFR3GeneProduct488808 (Entrez Gene)
FrzB-1GeneProduct
GHRGeneProduct403721 (Entrez Gene)
GLI3GeneProduct483244 (Entrez Gene)
Growth hormoneGeneProduct
HMGCS1GeneProduct479344 (Entrez Gene)
IFT88GeneProduct477345 (Entrez Gene)
IGF1GeneProduct610255 (Entrez Gene)
IGF1RGeneProduct442951 (Entrez Gene)
IGF2GeneProduct483664 (Entrez Gene)
IHHGeneProduct488533 (Entrez Gene)
KIF3AGeneProduct474675 (Entrez Gene)
LOC475245GeneProduct475245 (Entrez Gene) PMID: 17097081
LOC607662GeneProduct607662 (Entrez Gene)
MEF2CGeneProduct479155 (Entrez Gene)
MGPGeneProduct611039 (Entrez Gene)
MMP13GeneProduct403763 (Entrez Gene)
MMP9GeneProduct403885 (Entrez Gene)
NKX3-2GeneProduct488822 (Entrez Gene)
OxygenMetaboliteHMDB0001377 (HMDB)
PLATGeneProduct482840 (Entrez Gene)
PLAUGeneProduct403426 (Entrez Gene)
PRKACAGeneProduct403556 (Entrez Gene)
PTCHGeneProduct
PTCH1GeneProduct484137 (Entrez Gene)
PTH1RGeneProduct403779 (Entrez Gene)
PTHGeneProduct403986 (Entrez Gene)
PTHLHGeneProduct403987 (Entrez Gene)
RUNX2GeneProduct449531 (Entrez Gene)
RUNX3GeneProduct487366 (Entrez Gene)
SERPINH1GeneProduct485187 (Entrez Gene)
SLC38A2GeneProduct486596 (Entrez Gene)
SOX5GeneProduct486635 (Entrez Gene)
SOX6GeneProduct476871 (Entrez Gene)
SOX9GeneProduct403464 (Entrez Gene)
SPP1GeneProduct478471 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
TGFB1GeneProduct403998 (Entrez Gene)
TGFB2GeneProduct488596 (Entrez Gene)
THRAGeneProduct403601 (Entrez Gene)
TIMP3GeneProduct481289 (Entrez Gene)
TNAPGeneProduct
Thyroid hormoneMetaboliteCHEBI:60311 (ChEBI)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetaboliteCHEBI:24864 (ChEBI)
VEGFAGeneProduct403802 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions
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