Complement and Coagulation Cascades (Canis familiaris)

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DegredationZymosan,insulin, etc.Extrinsic pathwayCross-linkedfibrin polymerVascular injuryClassical PathwayCell adhesion,migration,profileration, etcC3b/BbFibrinolytic systemMuscle contraction,Chemotaxis,Phagocyte recruitmentInflammation, etc.ClotPlatelet, monocyte,lymphocyte,endothelial cells,smooth muscle cellsactivation, etcC4b/2aKinin kallikrein systemCoagulation CascadeMediatorsLectin PathwayCollagen,basement membrane,activated platelets, etc.C3aC3bAlternative PathwayCell lysisThrombinC3b/4b, C3b, C3dC4aComplement CascadeC5amembrane attack complexAntibody/antigencomplexC3Convertasefibrin degredationproductsCell adhesion,migration,profileration, etcC6PROCPLATCR2SERPINC1F3H2-BFFibrin monomerCFHC3109821PLGCPB2KNG1F8C4HcSERPINA1C4BPPROS1C1QCA2MC5AR1C8GF5ADNCFIC1QAC1QBF9MASP1SERPIND1F2F12SERPING1TFPILOC480771KLKB1Daf1C2Daf2SERPINE1C1RSERPINF2BradykininCD59APLAUF10SERPINA5C3AR1THBDCRRYFGBBDKRB1C1SCR1F13BMBL1MASP2VWFPLAURC7C9F7F2R


Description

No description

Comments

GenMAPP notes 
http://www.genome.jp/dbget-bin/get pathway?org name=mmu&mapno=04610
GenMAPP remarks 
Adapted from KEGG (see notes)
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP558(r22582) with a 67% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
89195view03:58, 23 August 2016AriuttaOntology Term : 'hemostasis pathway' added !
89194view03:58, 23 August 2016AriuttaOntology Term : 'complement system pathway' added !
89193view03:56, 23 August 2016AriuttaOntology Term : 'coagulation cascade pathway' added !
71454view19:16, 17 October 2013MaintBotAutomated update of data sources
68513view21:57, 5 July 2013MaintBotUpdated to 2013 gpml schema
40665view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
38706view19:28, 23 September 2010AlexanderPico
33957view18:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32259view12:59, 15 August 2009MaintBotFixed text labels
31783view12:12, 14 August 2009MaintBotFixed group labels
31286view20:04, 13 August 2009MaintBotFixed text labels
30741view23:03, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
A2MGeneProduct477699 (Entrez Gene)
ADNGeneProduct
BDKRB1GeneProduct490847 (Entrez Gene)
BradykininMetabolite
C1QAGeneProduct478194 (Entrez Gene)
C1QBGeneProduct487381 (Entrez Gene)
C1QCGeneProduct487382 (Entrez Gene)
C1RGeneProduct477707 (Entrez Gene)
C1SGeneProduct486714 (Entrez Gene)
C2GeneProduct
C3GeneProduct476728 (Entrez Gene)
C3AR1GeneProduct486704 (Entrez Gene)
C4GeneProduct
C4BPGeneProduct
C5AR1GeneProduct442974 (Entrez Gene)
C6GeneProduct479348 (Entrez Gene)
C7GeneProduct489221 (Entrez Gene) MGI:88235 LL:109828
C8GGeneProduct480672 (Entrez Gene)
C9GeneProduct479354 (Entrez Gene)
CD59AGeneProduct
CFHGeneProduct478952 (Entrez Gene)
CFIGeneProduct478515 (Entrez Gene)
CPB2GeneProduct608910 (Entrez Gene)
CR1GeneProduct609328 (Entrez Gene)
CR2GeneProduct490269 (Entrez Gene)
CRRYGeneProduct
Daf1GeneProduct
Daf2GeneProduct
F10GeneProduct476993 (Entrez Gene)
F12GeneProduct489090 (Entrez Gene)
F13BGeneProduct490261 (Entrez Gene)
F2GeneProduct
F2RGeneProduct488942 (Entrez Gene)
F3GeneProduct490153 (Entrez Gene)
F5GeneProduct
F7GeneProduct607661 (Entrez Gene)
F8GeneProduct403875 (Entrez Gene)
F9GeneProduct404015 (Entrez Gene)
FGBGeneProduct475472 (Entrez Gene)
Fibrin monomerMetabolite
H2-BFGeneProduct
HcGeneProduct
KLKB1GeneProduct475624 (Entrez Gene)
KNG1GeneProduct478666 (Entrez Gene)
LOC480771GeneProduct480771 (Entrez Gene)
MASP1GeneProduct488121 (Entrez Gene)
MASP2GeneProduct
MBL1GeneProduct
PLATGeneProduct482840 (Entrez Gene)
PLAUGeneProduct403426 (Entrez Gene)
PLAURGeneProduct476446 (Entrez Gene)
PLGGeneProduct403602 (Entrez Gene)
PROCGeneProduct476104 (Entrez Gene)
PROS1GeneProduct478529 (Entrez Gene)
SERPINA1GeneProduct480422 (Entrez Gene)
SERPINA5GeneProduct480424 (Entrez Gene)
SERPINC1GeneProduct480066 (Entrez Gene)
SERPIND1GeneProduct
SERPINE1GeneProduct403476 (Entrez Gene)
SERPINF2GeneProduct611266 (Entrez Gene)
SERPING1GeneProduct475966 (Entrez Gene)
TFPIGeneProduct403921 (Entrez Gene)
THBDGeneProduct474355 (Entrez Gene)
VWFGeneProduct399544 (Entrez Gene)
109821GeneProduct

Annotated Interactions

No annotated interactions
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