Id Signaling Pathway (Canis familiaris)

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Reaction through unknown mechanisms/moleculesInhibitionPhosphorylationDephosphorylationDeacetylationDDPNucleusAccession Number: NetPath 5; cellmap:5MTCY -> NURecruitmentDActivationAutophosphorylationPalmitoylationExtracellularEnzyme complexGOGolgi apparatusReceptorDGlycosylationNUCytoplasmDUbiquitinationControlDesumoylationEndosomeProteins in a complex interactionENID Gene RegulationProteolytic cleavageDemethylationDeubiquitinationEndoplasmic reticulumLigandSumoylationMolecule in the PathwayTranslocationMolecular association(Protein-protein interaction)PECPlasma membraneAcetylationMitochondriaCYPMethylationERPMPAX8CTNNB1SMAD5PAX2BMP6ACVRL1ATF3SMAD4TERTELK1BMP2ELK4IRS1ID2TCF3ID4ID3BMPR2SMAD3CCNA2LCKMYF5MYF6PI3KSMAD1IGF1ELK3RB1SREBF1FLT1ID1RELAHES1KDRMSCSMAD5IGF1RRASSMAD3ERKID2Gene SymbolMYOGIFI16PAX5MAPKCDK2SMAD4NGFTGFB1SMAD1TCF12EGFCCNE1CD40LGATF3TCRMYOD1RBL2RBL1PSMD4TCF7L2VEGFANFKB1


Inhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA binding capacity. This family of proteins is comprised of IDs 1, 2, 3 and 4. They can be stimulated by ligands such as the Vascular Endothelial Growth Factor (VEGF), TGF beta and the T cell receptor. Source: NetPath


GenMAPP notes 
NetPath 5; cellmap:5 - Id Signaling Pathway

The Id Signaling Pathway was kindly reviewed by Jonathan Perk and other members of Robert Benezra’s lab. This cancer signaling pathway is available at Cancer Cell Map ( and NetPath ( and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (, PandeyLab at Johns Hopkins University ( and Institute of Bioinformatics ( If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks;
This pathway was inferred from Homo sapiens pathway WP53(r20789) with a 71% conversion rate.

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Ontology Terms



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68600view23:26, 5 July 2013MaintBotUpdated to 2013 gpml schema
67356view10:41, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
40760view21:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35752view23:59, 12 February 2010AlexanderPico
34031view18:48, 9 December 2009MaintBotAutomatic update of empty xrefs
31284view20:03, 13 August 2009MaintBotFixed text labels
30737view23:01, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ACVRL1GeneProduct477603 (Entrez Gene)
ATF3GeneProduct612911 (Entrez Gene)
BMP2GeneProduct477162 (Entrez Gene)
CCNA2GeneProduct483845 (Entrez Gene)
CCNE1GeneProduct484610 (Entrez Gene)
CD40LGGeneProduct403468 (Entrez Gene)
CDK2GeneProduct606931 (Entrez Gene)
CTNNB1GeneProduct477032 (Entrez Gene)
EGFGeneProduct403657 (Entrez Gene)
ELK1GeneProduct491860 (Entrez Gene)
ELK3GeneProduct482613 (Entrez Gene)
ELK4GeneProduct488574 (Entrez Gene)
FLT1GeneProduct403727 (Entrez Gene)
Gene SymbolGeneProduct
ID1GeneProduct609779 (Entrez Gene)
ID3GeneProduct403547 (Entrez Gene)
IGF1GeneProduct610255 (Entrez Gene)
IGF1RGeneProduct442951 (Entrez Gene)
IRS1GeneProduct486148 (Entrez Gene)
KDRGeneProduct482154 (Entrez Gene)
LCKGeneProduct478151 (Entrez Gene)
MSCGeneProduct486992 (Entrez Gene)
MYF5GeneProduct482582 (Entrez Gene)
MYF6GeneProduct611531 (Entrez Gene)
MYOD1GeneProduct611940 (Entrez Gene)
MYOGGeneProduct490224 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
NGFGeneProduct403402 (Entrez Gene)
PAX2GeneProduct609228 (Entrez Gene)
PAX5GeneProduct612021 (Entrez Gene)
PAX8GeneProduct403927 (Entrez Gene)
PSMD4GeneProduct100192385 (Entrez Gene)
RB1GeneProduct476915 (Entrez Gene)
RBL1GeneProduct477221 (Entrez Gene)
RBL2GeneProduct478127 (Entrez Gene)
RELAGeneProduct483729 (Entrez Gene)
SMAD1GeneProduct475456 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SMAD4GeneProduct476196 (Entrez Gene)
SMAD5GeneProduct481520 (Entrez Gene)
SREBF1GeneProduct403475 (Entrez Gene)
TCF3GeneProduct485079 (Entrez Gene)
TCF7L2GeneProduct486894 (Entrez Gene)
TERTGeneProduct403412 (Entrez Gene)
TGFB1GeneProduct403998 (Entrez Gene)
VEGFAGeneProduct403802 (Entrez Gene)

Annotated Interactions

No annotated interactions
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