1, 2Co-SmadsCo-smadsCofactorsAccessory receptors:TGFbCofactorR-SmadsRsmadsligands:RepressorsSMAD1TGFB1SKITGFBR2NFKB1LTBP1LEF1JUNZNF423SMAD1SPP1FOSZFYVE9FOXH1TGIFSMAD6EP300EGFBMP4SMAD4SKILSMAD3HRASCREBBPSTAT1ENGRUNX2TGFBR2STAT3TFE3JAK1INHBATGFB1ZEB2SMAD7MAPK9FKBP1ATNFNOGBMP4RUNX3SMAD2MAPK3TGFBR3TNFTHBS1BAMBIIFNGSMAD2SMAD5LIFITGB6FSTSMAD9TGFBR1TGFBR1WNT1SERPINE1CTNNB1