Transforming Growth Factor (TGF) Beta Signaling Pathway (Canis familiaris)

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1, 2Co-SmadsCo-smadsCofactorsAccessory receptors:TGFbCofactorR-SmadsRsmadsligands:RepressorsSMAD1TGFB1SKITGFBR2NFKB1LTBP1LEF1JUNZNF423SMAD1SPP1FOSZFYVE9FOXH1TGIFSMAD6EP300EGFBMP4SMAD4SKILSMAD3HRASCREBBPSTAT1ENGRUNX2TGFBR2STAT3TFE3JAK1INHBATGFB1ZEB2SMAD7MAPK9FKBP1ATNFNOGBMP4RUNX3SMAD2MAPK3TGFBR3TNFTHBS1BAMBIIFNGSMAD2SMAD5LIFITGB6FSTSMAD9TGFBR1TGFBR1WNT1SERPINE1CTNNB1


Description

The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.

Comments

GenMAPP remarks 
edited by: Nathan Salomonis
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP560(r30273) with a 86% conversion rate.

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Ontology Terms

 

Bibliography

  1. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC
  2. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
87734view09:35, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87733view09:35, 25 July 2016MirellaKalafatiModified title
68512view21:56, 5 July 2013MaintBotUpdated to 2013 gpml schema
40664view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33956view18:22, 9 December 2009MaintBotAutomatic update of empty xrefs
31778view12:11, 14 August 2009MaintBotFixed group labels
30733view23:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BAMBIGeneProduct487081 (Entrez Gene)
BMP4GeneProduct490695 (Entrez Gene)
CREBBPGeneProduct479866 (Entrez Gene)
CTNNB1GeneProduct477032 (Entrez Gene)
EGFGeneProduct403657 (Entrez Gene)
ENGGeneProduct609166 (Entrez Gene)
EP300GeneProduct
FKBP1AGeneProduct608169 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
FOXH1GeneProduct482098 (Entrez Gene)
FSTGeneProduct479336 (Entrez Gene)
HRASGeneProduct
IFNGGeneProduct403801 (Entrez Gene)
INHBAGeneProduct483245 (Entrez Gene)
ITGB6GeneProduct488368 (Entrez Gene)
JAK1GeneProduct442952 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
LEF1GeneProduct478507 (Entrez Gene)
LIFGeneProduct403449 (Entrez Gene)
LTBP1GeneProduct475720 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
NOGGeneProduct
RUNX2GeneProduct449531 (Entrez Gene)
RUNX3GeneProduct487366 (Entrez Gene)
SERPINE1GeneProduct403476 (Entrez Gene)
SKIGeneProduct489610 (Entrez Gene)
SKILGeneProduct488159 (Entrez Gene)
SMAD1GeneProduct475456 (Entrez Gene)
SMAD2GeneProduct480144 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SMAD4GeneProduct476196 (Entrez Gene)
SMAD5GeneProduct481520 (Entrez Gene)
SMAD6GeneProduct487612 (Entrez Gene)
SMAD7GeneProduct490570 (Entrez Gene)
SMAD9GeneProduct486006 (Entrez Gene)
SPP1GeneProduct478471 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
TFE3GeneProduct491872 (Entrez Gene)
TGFB1GeneProduct403998 (Entrez Gene)
TGFBR1GeneProduct481628 (Entrez Gene)
TGFBR2GeneProduct477039 (Entrez Gene)
TGFBR3GeneProduct490163 (Entrez Gene)
TGIFGeneProduct
THBS1GeneProduct487486 (Entrez Gene) there are 5 types of tsp
TNFGeneProduct403922 (Entrez Gene)
WNT1GeneProduct486560 (Entrez Gene)
ZEB2GeneProduct483909 (Entrez Gene)
ZFYVE9GeneProduct475352 (Entrez Gene)
ZNF423GeneProduct

Annotated Interactions

No annotated interactions
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