TNF-alpha NF-kB Signaling Pathway (Canis familiaris)

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Proteolytic cleavageERGolgi apparatusSumoylationDephosphorylationReaction through unknown mechanisms/moleculesMTDemethylationActivationTranslocationPalmitoylationGOUbiquitinationLigandDeubiquitinationCY ->NUECReceptorRecruitmentEN(Protein-protein interaction)Endoplasmic reticulumExtracellularMolecular associationCY ->NUCY ->NUEndosomeGlycosylationNucleusDMolecule in the pathwayNUProteins in a complex interactionDeacetylationInhibitionEnzyme complexDesumoylationCY ->NUPMAutophosphorylationPlasma membraneCYMitochondrionAcetylationControlAccession Number: NetPath 9; cellmap:9MethylationCY ->NUCytoplasmPhosphorylationTRADDPSMD13TNIP1WDR68TXLNACHUKCREBBPPMLTNFBIRC2YWHAGFADDNFKBIATNFRSF11APIAS3NFKB1GLG1TRAF6ACTL6ALOC612286IKBKESRCDPF2TRADDKCNQ1HSP90AB1GeneGNB2L1RPL6GSK3BIQGAP2FLNACDC37AZI2RNF216PDCD2TNFRSF8KTN1UNC5CLGTF2IBCL7ALOC487309RPL30PSMC3RELBMAP3K3MAP3K7IP2KPNA3COPS3NFKB1MAP3K7IP3MAP3K8TBK1NALP4PSMD1POLR1BRIPK2STAT1PPP2CANFKBIZKPNA6SMARCE1Gene SymbolCASP10LOC486122POLR1CMTIF2YWHAZHIST3H3PAPOLANFKBIETRAF5YWHAHUBE2IRPL4PTPN11DDX3XPSMD12TRAIPNR2C2PSMD3KPNA2RELGAB1AKT1RELTBK1EIF4A3GeneBCL3CRADDCAV1G3BP2IKBKGFAF1BTRCCHUKTRAF2UBE2D2RELAUBCH5CPOLR1DPKN1PSMC2CUL1BIRC3MAP2K5FBXW11MAP3K7IP1POLR1EGeneLOC475035TNFRIPK1TNFCOMMD1ALPLRELBPOLR2LMAP3K14POLR2HNR2C2MCM7SMARCB1CYLDYWHABUSP11NFKB2MARK2RIPK3IKBKGNFKBIASMARCA4TNFRSF1ARPS11TNFRSF1BLRPPRCCDC34CD3EAPPEBP1TNFGeneTRAF1RPS6KB1RELAAKT2FANCD2RPL8BIRC3SMARCC1AKAP8TNFAIP3PRKACAMCCTNFCSNK2BIKBKAPHSPB1NKIRAS2TNFRSF1ATRAF4PRKCZRPS13NKIRAS1PFDN2SMARCC2IKBKBSUMO1CASP3TANKMCM5BIRC2RNF25NFKBIACAPN3TNFMAP3K2NFKBIBCFLARTIFACSNK2A1USP2RIPK1TRAF2RPS6KA5TRAF1TNIP2TRPC4APCASP7TRAF3TNFRSF1BCASP8TNFRSF1BPSMD7YWHAQPTK2PEG3FBLTNFRSF1ARELALOC480438PSMB5PSMD6DAPRASAL2CSNK2A2SKP1BAG4ZFAND5CASP2POLR1ATRAF2NSMAFTRAF4LOC480907MAP3K3NFKB1PSMC1FKBP5CASP8AP2RELAMAP3K1YWHAE


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 87% conversion rate.

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History

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CompareRevisionActionTimeUserComment
108149view10:36, 29 November 2019FehrhartOntology Term : 'cancer' added !
87779view11:09, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87778view11:08, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68568view22:53, 5 July 2013MaintBotUpdated to 2013 gpml schema
40726view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
34005view18:39, 9 December 2009MaintBotAutomatic update of empty xrefs
32256view12:58, 15 August 2009MaintBotFixed text labels
31777view12:10, 14 August 2009MaintBotFixed group labels
31281view20:02, 13 August 2009MaintBotFixed text labels
30732view23:00, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTL6AGeneProduct478637 (Entrez Gene)
AKAP8GeneProduct474362 (Entrez Gene)
AKT1GeneProduct490878 (Entrez Gene)
AKT2GeneProduct449021 (Entrez Gene)
ALPLGeneProduct403548 (Entrez Gene)
AZI2GeneProduct485632 (Entrez Gene)
BAG4GeneProduct607954 (Entrez Gene)
BCL3GeneProduct612349 (Entrez Gene)
BCL7AGeneProduct486256 (Entrez Gene)
BIRC2GeneProduct479464 (Entrez Gene)
BIRC3GeneProduct489433 (Entrez Gene)
BTRCGeneProduct486851 (Entrez Gene)
CAPN3GeneProduct487518 (Entrez Gene)
CASP10GeneProduct488472 (Entrez Gene)
CASP2GeneProduct482737 (Entrez Gene)
CASP3GeneProduct403567 (Entrez Gene)
CASP7GeneProduct486896 (Entrez Gene)
CASP8GeneProduct488473 (Entrez Gene)
CASP8AP2GeneProduct481921 (Entrez Gene)
CAV1GeneProduct403980 (Entrez Gene)
CD3EAPGeneProduct612284 (Entrez Gene)
CDC34GeneProduct476759 (Entrez Gene)
CDC37GeneProduct484955 (Entrez Gene)
CFLARGeneProduct488471 (Entrez Gene)
CHUKGeneProduct477796 (Entrez Gene)
COMMD1GeneProduct403590 (Entrez Gene)
COPS3GeneProduct479528 (Entrez Gene)
CRADDGeneProduct482604 (Entrez Gene)
CREBBPGeneProduct479866 (Entrez Gene)
CSNK2A1GeneProduct477185 (Entrez Gene)
CSNK2A2GeneProduct478108 (Entrez Gene)
CSNK2BGeneProduct474844 (Entrez Gene)
CUL1GeneProduct475512 (Entrez Gene)
CYLDGeneProduct611649 (Entrez Gene)
DAPGeneProduct607300 (Entrez Gene)
DDX3XGeneProduct480886 (Entrez Gene)
DPF2GeneProduct483743 (Entrez Gene) <