Hepatocyte growth factor receptor signaling (Canis familiaris)

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1CDC42pathwayAKT PathwayExtracellularAP-1RAC1pathwayTranscriptionof Cox2TrancriptionCytoplasmRHOpathwayTranscriptionChanges in Cytoskeletonand Cell mobilityActinAnoikisPTENITGA1CRKLMetSTAT3ELK1CRKPAK1MAPK8MAP2K1PIK3CARASA1MAPK3MAPK1RAP1BPTK2PXNRAP1ARAF1HRASHGFDOCK1MAP4K1PXNGRB2PTK2BSRCMAP2K2SOS1PTK2BFOSPTK2GAB1PTPN11ITGB1RAPGEF1SRCJUNPPP


Signaling pathway of the Hepatocyte Growth Factor Receptor (Homo sapiens) also know as C-Met. The C-Met activation results in the stimulation of a variety of intracellular signalling pathways, which regulate several processes such as: motility, migration, proliferation and invasion.


GenMAPP remarks 
Converted to human by GenMAPP.org
This pathway was inferred from Homo sapiens pathway WP313(r21339) with a 92% conversion rate.

Quality Tags

Ontology Terms



  1. Organ SL, Tsao MS; ''An overview of the c-MET signaling pathway.''; Ther Adv Med Oncol, 2011 PubMed Europe PMC Scholia


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118743view10:55, 1 June 2021DeSlOntology Term : 'Rho/Rac/Cdc42 mediated signaling pathway' added !
118742view10:55, 1 June 2021DeSlOntology Term : 'hepatocyte' added !
118741view10:54, 1 June 2021DeSlConverted "P" to states
118740view10:53, 1 June 2021DeSlConverted unconnected lines to Graphical Lines
118739view10:53, 1 June 2021DeSlRemoved textlabel
118737view10:52, 1 June 2021DeSlConverted ReceptorSquare to MIM binding with lit ref
118736view10:51, 1 June 2021DeSlAdded description from WP313
118036view11:49, 23 May 2021EweitzModified title
87666view08:55, 25 July 2016LindarieswijkOntology Term : 'scatter factor/hepatocyte growth factor signaling pathway' added !
68535view22:20, 5 July 2013MaintBotUpdated to 2013 gpml schema
40691view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
33976view18:30, 9 December 2009MaintBotAutomatic update of empty xrefs
32255view12:57, 15 August 2009MaintBotFixed text labels
31776view12:10, 14 August 2009MaintBotFixed group labels
31280view20:02, 13 August 2009MaintBotFixed text labels
30731view22:59, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CRKLGeneProduct608125 (Entrez Gene)
DOCK1GeneProduct486934 (Entrez Gene) Interim Symbol: Dock1 predicted and Name: dedicator of cyto-kinesis 1 (predicted)
ELK1GeneProduct491860 (Entrez Gene)
FOSGeneProduct490792 (Entrez Gene)
GAB1GeneProduct483808 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
HGFGeneProduct403441 (Entrez Gene)
ITGA1GeneProduct489210 (Entrez Gene)
ITGB1GeneProduct477956 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAP4K1GeneProduct484527 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MetGeneProduct403438 (Entrez Gene)
PAK1GeneProduct607885 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PTENGeneProduct403832 (Entrez Gene)
PTK2GeneProduct475108 (Entrez Gene)
PTK2BGeneProduct486102 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
PXNGeneProduct486299 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RAP1AGeneProduct483225 (Entrez Gene)
RAP1BGeneProduct608981 (Entrez Gene)
RAPGEF1GeneProduct491286 (Entrez Gene)
RASA1GeneProduct479158 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene) Son of sevenless homolog 1 (Drosophila) (predicted)
SRCGeneProduct485864 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)

Annotated Interactions

No annotated interactions
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