ACE Inhibitor Pathway (Canis familiaris)

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1Cell MembraneACEAldosteroneAGTR2KNG1BDKRB2ACE InhibitorAngiotensin IAGTR1ACEAngiotensin IIBradykininNOS3AGTREN


The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (


This pathway was inferred from Homo sapiens pathway WP554(r30178) with a 88% conversion rate.

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Ontology Terms



  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC


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106052view11:57, 16 August 2019MaintBotHMDB identifier normalization
85435view09:40, 15 May 2016Egonw
85432view09:37, 15 May 2016EgonwQuick edit to datanode annotation or property
71478view19:18, 17 October 2013MaintBotAutomated update of data sources
68571view22:57, 5 July 2013MaintBotUpdated to 2013 gpml schema
67017view09:54, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
57077view20:14, 20 January 2013EgonwUsed "PubChem-compound"
40729view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35049view09:36, 11 February 2010Thomasremoved genmapp notes (invalid link)
35041view09:29, 11 February 2010ThomasModified description
34008view18:41, 9 December 2009MaintBotAutomatic update of empty xrefs
31769view12:08, 14 August 2009MaintBotFixed group labels
30720view22:56, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ACE InhibitorMetaboliteCHEBI:35457 (ChEBI)
ACEGeneProduct610668 (Entrez Gene)
AGTGeneProduct403783 (Entrez Gene)
AGTR1GeneProduct403836 (Entrez Gene)
AGTR2GeneProduct403835 (Entrez Gene)
AldosteroneMetaboliteC01780 (KEGG Compound)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
BDKRB2GeneProduct403658 (Entrez Gene)
BradykininMetaboliteHMDB0004246 (HMDB)
KNG1GeneProduct478666 (Entrez Gene)
NOS3GeneProduct403784 (Entrez Gene)
RENGeneProduct403838 (Entrez Gene)

Annotated Interactions

No annotated interactions
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