Selenium metabolism Selenoproteins (Canis familiaris)

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1-4, 6, 9...RedoxsignallingSeCThyroid hormonemetabolismProtein foldingAUGINORGANIC SedemethylationBody proteinsSe = Selenium, SeMet = SelenoMethionine, SeC = Selcysteine, H2Se = Selenide, GSH = gluthatione, Trx = ThioredoxinGSHSelenoproteinsSe transportand storageORGANIC SeUnkownfunctionnucleusSec tRNA[ser]secSeryl-tRNA[ser](sec)Phosphoseryl-tRNA[ser](sec)STOPcoding regionSelenocysteyl-tRNA secTranscription FactorsSeC BiosynthesisTrXSeCAntioxidantenzymesDietSecsynthesisSelenium binding proteinsmethyl transferaseSBP2DIO2SEPX1SP3JUNTXNRD2Pouf2f1GPX2SeMetSEPP1SelenophosphateSCLYSELSNfe2l2EEFSECGPX1PstkSeCSeMetUGASARS2TXNRD3GPX3SELMSelVSELKRELASEPN1SelenateFOSCremSelTSeleniteNFKB1MethylSelenol MeSeHSEPHS2SelHSarsTXNRD3SELENBP1SEPW1SeleniteSBP2FABP1TRNAU1APSelenateSeCSephs2SelIEEFSECGPX6SELOSp1Sephs1SEPSECSH2SeTXNRD1RPL30DIO1SBP2Sep15TXNRD1Cystathionine g-lyaseDIO3TXNRD2GPX45, 8, 117, 8


* Comments belonging to specific genes on the Selenoprotein pathway
    • TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy.
    • Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase
    • A selenoprotein database exists at:


This pathway was inferred from Homo sapiens pathway WP28(r30051) with a 54% conversion rate.

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  1. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL; ''Biosynthesis of selenocysteine on its tRNA in eukaryotes.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  2. Small-Howard AL, Berry MJ; ''Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes.''; Biochem Soc Trans, 2005 PubMed Europe PMC Scholia
  3. PubMed Europe PMC Scholia
  4. Soda K, Oikawa T, Esaki N; ''Vitamin B6 enzymes participating in selenium amino acid metabolism.''; Biofactors, 1999 PubMed Europe PMC Scholia
  5. Wang H, Zhang J, Yu H; ''Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice.''; Free Radic Biol Med, 2007 PubMed Europe PMC Scholia
  6. Papp LV, Lu J, Holmgren A, Khanna KK; ''From selenium to selenoproteins: synthesis, identity, and their role in human health.''; Antioxid Redox Signal, 2007 PubMed Europe PMC Scholia
  7. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF; ''Effectiveness of selenium supplements in a low-selenium area of China.''; Am J Clin Nutr, 2005 PubMed Europe PMC Scholia
  8. PubMed Europe PMC Scholia
  9. Gromer S, Eubel JK, Lee BL, Jacob J; ''Human selenoproteins at a glance.''; Cell Mol Life Sci, 2005 PubMed Europe PMC Scholia
  10. Boosalis MG; ''The role of selenium in chronic disease.''; Nutr Clin Pract, 2008 PubMed Europe PMC Scholia
  11. Ip C, Hayes C; ''Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection.''; Carcinogenesis, 1989 PubMed Europe PMC Scholia


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106051view11:56, 16 August 2019MaintBotHMDB identifier normalization
87649view08:54, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
71461view19:17, 17 October 2013MaintBotAutomated update of data sources
68525view22:09, 5 July 2013MaintBotUpdated to 2013 gpml schema
62718view03:16, 2 May 2013MaintBotUpdated UniProt data source
58842view23:34, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40679view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
33969view18:27, 9 December 2009MaintBotAutomatic update of empty xrefs
32252view12:56, 15 August 2009MaintBotFixed text labels
31768view12:08, 14 August 2009MaintBotFixed group labels
31273view19:59, 13 August 2009MaintBotFixed text labels
30718view22:55, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CremGeneProduct403887 (Entrez Gene)
Cystathionine g-lyaseGeneProduct
DIO1GeneProduct403635 (Entrez Gene)
DIO2GeneProduct490813 (Entrez Gene)
DIO3GeneProduct612596 (Entrez Gene)
EEFSECGeneProduct476514 (Entrez Gene)
FABP1GeneProduct403619 (Entrez Gene)
FOSGeneProductENSCAFG00000017040 (Ensembl)
GPX1GeneProduct442961 (Entrez Gene)
GPX2GeneProduct480356 (Entrez Gene)
GPX3GeneProduct489179 (Entrez Gene)
JUNGeneProductENSCAFG00000018897 (Ensembl)
MethylSelenol MeSeHMetabolite
NFKB1GeneProduct442859 (Entrez Gene)
Nfe2l2GeneProduct478813 (Entrez Gene)
PstkGeneProduct477855 (Entrez Gene)
RELAGeneProduct483729 (Entrez Gene)
RPL30GeneProduct480751 (Entrez Gene)
SARS2GeneProduct484518 (Entrez Gene)
SCLYGeneProduct477422 (Entrez Gene)
SELENBP1GeneProduct475847 (Entrez Gene)
SELKGeneProduct476586 (Entrez Gene)
SELMGeneProduct611981 (Entrez Gene)
SELOGeneProduct481194 (Entrez Gene)
SELSGeneProduct607791 (Entrez Gene)
SEPHS2GeneProduct489904 (Entrez Gene)
SEPN1GeneProduct612211 (Entrez Gene)
SEPP1GeneProduct479346 (Entrez Gene)
SEPSECSGeneProduct488852 (Entrez Gene)
SEPW1GeneProduct612109 (Entrez Gene)
SEPX1GeneProduct611032 (Entrez Gene)
SP3GeneProduct488405 (Entrez Gene)
SarsGeneProduct490124 (Entrez Gene)
SeCMetaboliteHMDB0003288 (HMDB)
SeMetMetaboliteHMDB0003966 (HMDB)
SelHGeneProduct100303415 (Entrez Gene)
SelIGeneProduct100302747 (Entrez Gene)
SelTGeneProduct477113 (Entrez Gene)
SelVGeneProduct100303414 (Entrez Gene)
SelenophosphateMetaboliteHMDB0006407 (HMDB)
Sep15GeneProduct612493 (Entrez Gene)
Sephs1GeneProduct477999 (Entrez Gene)
Sephs2GeneProduct489904 (Entrez Gene)
Sp1GeneProduct486507 (Entrez Gene)
TRNAU1APGeneProduct478164 (Entrez Gene)
TXNRD1GeneProduct474536 (Entrez Gene)
TXNRD2GeneProduct608155 (Entrez Gene)
TXNRD3GeneProduct484619 (Entrez Gene)

Annotated Interactions

No annotated interactions
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