mRNA Processing (Canis familiaris)

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1splicing factor SF3BCPSF3'GUU2AFSR protein phosphatasesAFormation of pre-mRNPsFormation of the Spliceosomal C complex(2a)SR-proteinsAG5'U4/U6AAdditional FactorsSR-proteins5' G capU4:U5:U6 tri-snRNP complexexon 2Serine/Argenine Rich Proteins(SR)A3'exon 2Formation of the Spliceosomal E complexU6Spt5Poly(A) polymerase alphaexon 1exon 2RNAi pathway3'Methylation of mRNAexon 2exon 1Additional FactorsSR protein kinasessplicing factor SF3AAGPoly(A)-binding protein IIU2 snRNPP-mRNA Capping(2b)intronSR-binding sites3'5'right click on blue text for detailed informationPiCap BindingPoly(A)pb IIYYYYYYYYsnRNP Sm core complex65CF IIRNA helicase ASR-proteins(3)3'U1 snRNPU1AG5'AFormation of the Spliceosomal E complexRNA helicaseU6 snRNPCF IIsnRNP Sm core complex(1)5'5'CstFPutative Alternative SplicingRegulatorsARnmt (methyltransferase)U2 snRNPFormation of the active Spliceosomal C complexAAUAAAhnRNPsU2U4 snRNPexon 1iPoSR-binding sitesPrimary RNA transcriptmRNA splicing (major pathway)U5AGSR-kinasesAdditional FactorsRegulation ofAlternative SplicingmRNA splice site selectionFormation of the Spliceosomal A complex3'(2c)SF3b14bFormation of the Spliceosomal A complexInternal methylation of mRNAA5'35Poly(A) polAGAAAAAAAPolr2aSR-phosphatasesexon 1YYYYU5CPSFFormation of the Spliceosomal B complexAdditional SR proteinsCstFU2AFexon 25'3'3'U2 snRNPsYYYYexon 1U1 snRNPPYYYYInternal methylation of mRNAUGSR-repressor proteinsAGdegradedUGAccessory Proteinsexon 1(2)5'heterogeneous nuclear ribonucleoproteinsCleavage of mRNA at the 3'-endMisc.U5 snRNPFormation of pre-mRNPsexon 2Lariat Formation and 5'-Splice Site CleavageNote: New participating members shown at each steppre-mRNACACFImRNA 3'-end processingU4mRNA cappingFormation of the Spliceosomal B complexmRNA polyadenylationKinases Phosphorylating RS domains?snRNP Sm core complexRngtt (capping enzyme)CF Isplicesome associated helicases5'Cleavage at the 3'-Splice-Site and Exon LigationProcessing of Intron-Containing Pre-mRNA5'3'5'3'YYYY3'hnRNP regulatorsSUPT5HDHX8SRSF7RNMTSNRPGCSTF2THNRNPMDHX16DHX15SRSF5CPSF2SRSF2PRPF18PRPF8Rnu6PRPF3HNRNPUCD2BP2CLK1CSTF3U5 snRNASNRNP40CSTF1SMC1APSKH1SF3B5SNRPNFUSIP1SNRPBBRUNOL4PRPF4NCBP2HNRPKPRPF4HNRNPABDHX38U4 snRNAPTBP1CPSF4SRSF4CLK3CPSF3SUGP2HNRPA3P1SSFA1FUSU2AF2TMED10SPOPSSFA1SRRM1SF3B2CPSF1LSM7FUSIP1SF3A2SNRPNRBM5RNGTTGMPDICER1PRMT2HNRNPH1RBMXU1 snRNARBM39RNPS1SNRPFPCBP2HNRNPA2B1HNRPA1EFTUD2TXNL4ADHX9SNRPB2SNRPD1HNRNPDATPPRPF4BHNRPLPRMT1PABPN1SNRNP70HNRPCNXF1SFSWAPSRSF1RBM17SREK1TRA2BCELF2SNRPD3DDX20DNAJC8SRPK2NSEP1SNRPAU2AF1PHF5ASF3B4SNRPEPRPF40APRPF6DDX1HNRNPH2CLK2SNRPA1CLK4LSM2CELF1PPM1GPOLR2ACDC40SNRPD2LSM2SFPQNUDT21NCBP1XRN2CLP1RNU2PRPF8CDC40SRPK1SF3B3NONOSSFA1SRSF3SF3B1HNRNPRSRSF9PTBP2SRSF6METTL3CLASRPCSTF2SF3A3SRP54SUGP1PAPOLASF3A1


Description

This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA).

The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated.

5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds.

3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion.

Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule.

Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification

Pathway adapted from http://www.reactome.org.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP411 (r95128) with a 88.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Carmody SR, Wente SR; ''mRNA nuclear export at a glance.''; J Cell Sci, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95765view14:20, 19 January 2018MkutmonHomology conversion update
71483view19:18, 17 October 2013MaintBotAutomated update of data sources
69956view20:51, 11 July 2013MaintBotupdated to 2013 schema
68581view23:08, 5 July 2013MaintBotUpdated to 2013 gpml schema
67493view11:09, 26 June 2013DdiglesOntology Term : 'spliceosome pathway' added !
48160view18:58, 9 May 2012MaintBotUpdating from human to fix xrefs
40740view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35243view19:50, 11 February 2010KhanspersModified description
34015view18:43, 9 December 2009MaintBotAutomatic update of empty xrefs
32569view13:12, 17 August 2009MaintBotFixed text labels
32247view12:54, 15 August 2009MaintBotFixed text labels
31762view12:06, 14 August 2009MaintBotFixed group labels
31267view19:57, 13 August 2009MaintBotFixed text labels
30711view22:53, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
BRUNOL4GeneProductNo homologues found for original id L:56853
CD2BP2GeneProductENSCAFG00000016943 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10421
CDC40GeneProductENSCAFG00000003868 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51362
CELF1GeneProductENSCAFG00000008452 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10658
CELF2GeneProductENSCAFG00000004973 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10659
CLASRPGeneProductENSCAFG00000004587 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11129
CLK1GeneProductENSCAFG00000011929 (Ensembl)
  • PMID: 15010457: Inhibitor John C. Bell, PhD

    Professor, Depts. of Medicine and Biochemistry, Microbiology & Immunology University of Ottawa Career Scientist, Ottawa Regional Cancer Centre Associate Scientist, The Ottawa Hospital Research Institute Telephone: 613-737-7700 ext 6893 Fax: 613-247-3524 Email: John.Bell@orcc.on.ca The control of pre-mRNA splicing by the Clk kinase family

    We are studying a family of kinases which we believe provide an interface between intracellular signaling networks and the post-transcriptional mechanism of mRNA splicing. We are performing a structure:function analysis of the three Clk family members to identify domains in the three proteins which are involved in regulating splicing. Using homologous recombination we are generating null strains of mice which are lacking one, two or all three Clk genes. The Clk kinases all possess dual specificity kinase activity and yeast expression systems are being used to produce large amounts of the kinase to perform a detailed analysis of the sites of serine, threonine and tyrosine autophosphorylation within the kinase.
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1195
CLK2GeneProductENSCAFG00000016969 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1196
CLK3GeneProductENSCAFG00000017904 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1198
CLK4GeneProductENSCAFG00000000248 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57396
CLP1GeneProductENSCAFG00000007815 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10978
CPSF1GeneProductENSCAFG00000001600 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:29894
CPSF2GeneProductENSCAFG00000010909 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:53981
CPSF3GeneProductENSCAFG00000003375 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51692
CPSF4GeneProductENSCAFG00000015036 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10898
CSTF1GeneProductENSCAFG00000011914 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1477
CSTF2GeneProductENSCAFG00000017551 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1478
CSTF2TGeneProductENSCAFG00000015567 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23283
CSTF3GeneProductENSCAFG00000007264 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1479
DDX1GeneProductENSCAFG00000003686 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1653
DDX20GeneProductENSCAFG00000013674 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11218
DHX15GeneProductENSCAFG00000016505 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1665
DHX16GeneProductENSCAFG00000000427 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8449
DHX38GeneProductENSCAFG00000020228 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9785
DHX8GeneProductENSCAFG00000014556 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1659
DHX9GeneProductENSCAFG00000013205 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1660
DICER1GeneProductENSCAFG00000017701 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23405
DNAJC8GeneProductNo homologues found for original id L:22826
EFTUD2GeneProductENSCAFG00000014065 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9343
FUSGeneProductENSCAFG00000016862 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2521
FUSIP1GeneProductNo homologues found for original id L:10772
GMPMetabolite85-32-5 (CAS)
HNRNPA2B1GeneProductENSCAFG00000002885 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3181
HNRNPABGeneProductENSCAFG00000000241 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3182
HNRNPDGeneProductENSCAFG00000025045 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3184
HNRNPH1GeneProductENSCAFG00000000336 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3187
HNRNPH2GeneProductENSCAFG00000017693 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3188
HNRNPMGeneProductENSCAFG00000018524 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4670
HNRNPRGeneProductENSCAFG00000013308 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10236
HNRNPUGeneProductENSCAFG00000015835 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3192
HNRPA1GeneProductENSCAFG00000017316 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3178
HNRPA3P1GeneProduct
HNRPCGeneProductENSCAFG00000018380 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3183
HNRPKGeneProductNo homologues found for original id L:3190
HNRPLGeneProductENSCAFG00000005652 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3191
LSM2GeneProductNo homologues found for original id L:57819
LSM7GeneProductENSCAFG00000019409 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51690
METTL3GeneProductENSCAFG00000005657 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:56339
NCBP1GeneProductENSCAFG00000002445 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4686
NCBP2GeneProductENSCAFG00000013100 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:22916
NONOGeneProductENSCAFG00000017071 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4841
NSEP1GeneProductENSCAFG00000002541 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4904
NUDT21GeneProductENSCAFG00000002667 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11051
NXF1GeneProductENSCAFG00000015594 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10482
PABPN1GeneProductENSCAFG00000011482 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8106
PAPOLAGeneProductENSCAFG00000017783 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10914
PCBP2GeneProductNo homologues found for original id L:5094
PHF5AGeneProductENSCAFG00000001090 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:84844
POLR2AGeneProductNo homologues found for original id L:5430
PPM1GGeneProductENSCAFG00000004923 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5496
PRMT1GeneProductENSCAFG00000003589 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3276
PRMT2GeneProductENSCAFG00000012237 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3275
PRPF18GeneProductENSCAFG00000004735 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8559
PRPF3GeneProductENSCAFG00000011820 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9129
PRPF40AGeneProductENSCAFG00000005827 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:55660
PRPF4BGeneProductENSCAFG00000009381 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8899
PRPF4GeneProductENSCAFG00000003224 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9128
PRPF6GeneProductENSCAFG00000013165 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:24148
PRPF8GeneProductENSCAFG00000019221 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10594
PSKH1GeneProductENSCAFG00000020335 (Ensembl)
  • PMID: 12466556
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5681
PTBP1GeneProductENSCAFG00000019693 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5725
PTBP2GeneProductENSCAFG00000020080 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:58155
RBM17GeneProductENSCAFG00000005206 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:84991
RBM39GeneProductENSCAFG00000008327 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9584
RBM5GeneProductENSCAFG00000010866 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10181
RBMXGeneProductENSCAFG00000018962 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:27316
RNGTTGeneProductENSCAFG00000003089 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8732
RNMTGeneProductENSCAFG00000000172 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8731
RNPS1GeneProductENSCAFG00000019397 (Ensembl)
  • PMID: 14729963
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10921
RNU2GeneProduct
  • GenBank sequence: K00027
  • No homologues found for original id L:6066
Rnu6RnaGenBank sequence: M10329
SF3A1GeneProductENSCAFG00000012559 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10291
SF3A2GeneProductENSCAFG00000019414 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8175
SF3A3GeneProductENSCAFG00000003222 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10946
SF3B1GeneProductENSCAFG00000010826 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23451
SF3B2GeneProductENSCAFG00000013033 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10992
SF3B3GeneProductENSCAFG00000020151 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23450
SF3B4GeneProductENSCAFG00000011617 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10262
SF3B5GeneProductENSCAFG00000032495 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:83443
SFPQGeneProductENSCAFG00000017608 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6421
SFSWAPGeneProductENSCAFG00000006625 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6433
SMC1AGeneProductENSCAFG00000016241 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8243
SNRNP40GeneProductENSCAFG00000011149 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9410
SNRNP70GeneProductENSCAFG00000003711 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6625
SNRPA1GeneProductENSCAFG00000010564 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6627
SNRPAGeneProductENSCAFG00000005091 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6626
SNRPB2GeneProductENSCAFG00000024887 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6629
SNRPBGeneProductENSCAFG00000031109 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6628
SNRPD1GeneProductENSCAFG00000018247 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6632
SNRPD2GeneProductENSCAFG00000004403 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6633
SNRPD3GeneProductENSCAFG00000013864 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6634
SNRPEGeneProductENSCAFG00000002085 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6635
SNRPFGeneProductENSCAFG00000031151 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6636
SNRPGGeneProductNo homologues found for original id L:6637
SNRPNGeneProductENSCAFG00000030577 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6638
SPOPGeneProductENSCAFG00000016942 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8405
SREK1GeneProductENSCAFG00000007560 (Ensembl)
  • PMID: 14559993. SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region. Previously, we showed that SRrp86 could regulate alternative splicing by both positively and negatively modulating the activity of other SR proteins and that the unique EK domain could inhibit both constitutive and alternative splicing. These functions were most consistent with the model in which SRrp86 functions by interacting with and thereby modulating the activity of target proteins. To identify the specific proteins that interact with SRrp86, we used a yeast two-hybrid library screen and immunoprecipitation coupled to mass spectrometry. We show that SRrp86 interacts with all of the core SR proteins, as well as a subset of other splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72. In contrast to previous results that showed activation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of SRrp86. Overall, we conclude that not only does SRrp86 regulate SR protein activity but that it is, in turn, regulated by other splicing factors to control alternative splice site selection.
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:140890
SRP54GeneProductENSCAFG00000013331 (Ensembl)
  • PMID: 14729963
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6729
SRPK1GeneProductENSCAFG00000001364 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6732
SRPK2GeneProductENSCAFG00000004057 (Ensembl)
  • PMID: 12773558
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6733
SRRM1GeneProductENSCAFG00000012933 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10250
SRSF1GeneProductENSCAFG00000017430 (Ensembl)
  • Antagonist splicing factor
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6426
SRSF2GeneProductENSCAFG00000005147 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6427
SRSF3GeneProductENSCAFG00000001414 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6428
SRSF4GeneProductENSCAFG00000011669 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6429
SRSF5GeneProductENSCAFG00000016589 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6430
SRSF6GeneProductENSCAFG00000009289 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6431
SRSF7GeneProductENSCAFG00000029620 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6432
SRSF9GeneProductENSCAFG00000010314 (Ensembl)
  • PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8683
SSFA1GeneProductENSCAFG00000018660 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4809
SUGP1GeneProductENSCAFG00000014314 (Ensembl)
  • inferred from: SURP 2, G patch protein, UniProt:O60378
  • Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57794
SUGP2GeneProductENSCAFG00000014431 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10147
SUPT5HGeneProductENSCAFG00000005469 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6829
TMED10GeneProductENSCAFG00000017034 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10972
TRA2BGeneProductENSCAFG00000013345 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6434
TXNL4AGeneProductENSCAFG00000000008 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10907
U1 snRNARnaGenBank sequence: J00645
U2AF1GeneProductENSCAFG00000010572 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7307
U2AF2GeneProductENSCAFG00000002551 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11338
U4 snRNARnaGenBank sequence: M10328, M18004
U5 snRNARnaGenBank sequence: AB021173
XRN2GeneProductENSCAFG00000005185 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:22803

Annotated Interactions

No annotated interactions
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