Type II interferon signaling (IFNG) (Canis familiaris)

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1TPBORP[P] [P]PlasmaMembrane[P]OORBBBCytoplasmORNucleusOR-P&[P]TAP&OROTPPB[P]ExtracellularSpaceIRF2PSMB9LOC490008IFIT2IRF9STAT1STAT1IRF9STAT1CXCL9JAK2STAT2IFNGIFNGR2HLA-BIRF1STAT1JAK1LOC478170IRF9STAT1JAK1STAT1IFNASOCS1STAT1IFNGR1OAS1GBP1STAT2CXCL10IFNGR1IRF9STAT1IFNB1JAK1SPI1JAK1STAT2EIF2AK2IFNGR1ISG15TAP1IFNGR2HIST2H4NOS2SOCS3JAK2ICAM1STAT1IFNGPTPN11STAT1STAT1STAT1CYBBIFNGPRKCDSTAT1IRF9IFNGIL1BSTAT2IFNGR2STAT1IRF8IFNGR1PTPIRF8IRF9JAK2STAT1STAT1IFNGIFNGR2IRF9IRF4JAK2STAT1


Description

Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP619(r28124) with a 91% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, Freeman TC; ''A logic-based diagram of signalling pathways central to macrophage activation.''; BMC Syst Biol, 2008 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
87829view11:44, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68518view22:02, 5 July 2013MaintBotUpdated to 2013 gpml schema
40672view21:49, 1 March 2011MaintBotRemoved redundant pathway information and comments
33962view18:25, 9 December 2009MaintBotAutomatic update of empty xrefs
32566view13:11, 17 August 2009MaintBotFixed text labels
32245view12:54, 15 August 2009MaintBotFixed text labels
31757view12:05, 14 August 2009MaintBotFixed group labels
31264view19:56, 13 August 2009MaintBotFixed text labels
30705view22:51, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CXCL10GeneProduct478432 (Entrez Gene)
CXCL9GeneProduct
CYBBGeneProduct491825 (Entrez Gene)
EIF2AK2GeneProduct611397 (Entrez Gene)
GBP1GeneProduct490172 (Entrez Gene)
HIST2H4GeneProduct448780 (Entrez Gene)
HLA-BGeneProduct
ICAM1GeneProduct403975 (Entrez Gene)
IFIT2GeneProduct479183 (Entrez Gene)
IFNAGeneProduct
IFNB1GeneProduct481558 (Entrez Gene)
IFNGGeneProduct403801 (Entrez Gene)
IFNGR1GeneProduct476216 (Entrez Gene)
IFNGR2GeneProduct487739 (Entrez Gene)
IL1BGeneProduct403974 (Entrez Gene)
IRF1GeneProduct481500 (Entrez Gene)
IRF2GeneProduct475633 (Entrez Gene)
IRF4GeneProduct
IRF8GeneProduct489673 (Entrez Gene)
IRF9GeneProduct607899 (Entrez Gene)
ISG15GeneProduct479575 (Entrez Gene)
JAK1GeneProduct442952 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
LOC478170GeneProduct478170 (Entrez Gene)
LOC490008GeneProduct490008 (Entrez Gene)
NOS2GeneProduct403822 (Entrez Gene)
OAS1GeneProduct608778 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PSMB9GeneProduct474867 (Entrez Gene)
PTPGeneProduct
PTPN11GeneProduct477488 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SPI1GeneProduct611255 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT2GeneProduct481111 (Entrez Gene)
TAP1GeneProduct

Annotated Interactions

No annotated interactions
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