Wnt Signaling Pathway (Canis familiaris)

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1Recruitment to UnknownBCytoskeleton-CateninTranscriptional ActivationApoptosisUbiquitin Conjugating EnzymePhosphorylatedPUbiquitin TaggedB - CateninFrizzled Ligands26S Proteasome DegredationNucleusWNT7AMAPK9FBXW2FZD9APCWNT3AWNT5BPAFAH1B1PRKCIMYCFZD10PRKCQRHOACCND3PPP2R5EFRAT1MAPK10WNT5APLAUDVL3WNT2PRKCZFZD7DVL2WNT7BPRKCAPRKCDRAC1WNT11GSK3BFZD3FZD1FZD5WNT10APRKD1AXIN1CCND1WNT6WNT3CTNNB1FOSL1FZD8DVL1PRKCHFZD6CCND2TCF-1/LEFWNT16PRKCGJUNWNT10BPPP2R5CWNT16WNT1SFRP4WNT4FZD2PRKCBCSNK1EWNT2BLDLRPRKCE


Description

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP428(r28695) with a 90% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
79839view08:06, 18 April 2015EgonwAdded two missing gene identifiers.
79430view23:44, 21 March 2015Khanspersupdate schema
79429view23:44, 21 March 2015KhanspersReverted to version '11:58, 26 June 2013' by Khanspers
68563view22:48, 5 July 2013MaintBotUpdated to 2013 gpml schema
67748view11:58, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
40721view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35129view13:40, 11 February 2010Thomasconnected line
35121view13:25, 11 February 2010Thomasadded literature
35111view13:17, 11 February 2010ThomasModified description
34000view18:38, 9 December 2009MaintBotAutomatic update of empty xrefs
32565view13:10, 17 August 2009MaintBotFixed text labels
32244view12:53, 15 August 2009MaintBotFixed text labels
31756view12:04, 14 August 2009MaintBotFixed group labels
31263view19:56, 13 August 2009MaintBotFixed text labels
30704view22:50, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
APCGeneProduct479139 (Entrez Gene)
AXIN1GeneProduct490099 (Entrez Gene)
CCND1GeneProduct449028 (Entrez Gene)
CCND2GeneProduct611782 (Entrez Gene)
CCND3GeneProduct608847 (Entrez Gene)
CSNK1EGeneProduct474510 (Entrez Gene)
CTNNB1GeneProduct477032 (Entrez Gene)
DVL1GeneProduct489593 (Entrez Gene)
DVL2GeneProduct489464 (Entrez Gene)
DVL3GeneProduct478650 (Entrez Gene)
FBXW2GeneProduct610990 (Entrez Gene)
FOSL1GeneProduct483724 (Entrez Gene)
FRAT1GeneProduct
FZD10GeneProduct486232 (Entrez Gene)
FZD1GeneProduct482294 (Entrez Gene)
FZD2GeneProduct490937 (Entrez Gene)
FZD3GeneProduct486093 (Entrez Gene)
FZD5GeneProduct488493 (Entrez Gene)
FZD6GeneProduct403610 (Entrez Gene)
FZD7GeneProduct488478 (Entrez Gene)
FZD8GeneProduct
FZD9GeneProduct489809 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene) MOUSE:KG38 MOUSE
JUNGeneProduct609429 (Entrez Gene)
LDLRGeneProduct100683160 (Entrez)
MAPK10GeneProduct478464 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
PAFAH1B1GeneProduct480656 (Entrez Gene)
PLAUGeneProduct403426 (Entrez Gene)
PPP2R5CGeneProduct480436 (Entrez Gene)
PPP2R5EGeneProduct480349 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCEGeneProduct609934 (Entrez Gene)
PRKCGGeneProduct484316 (Entrez Gene)
PRKCHGeneProduct490722 (Entrez Gene)
PRKCIGeneProduct478686 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PRKD1GeneProduct609091 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RHOAGeneProduct403954 (Entrez Gene)
SFRP4GeneProduct483258 (Entrez Gene)
TCF-1/LEFGeneProduct478507 (Entrez)
WNT10AGeneProduct488528 (Entrez Gene)
WNT10BGeneProduct486561 (Entrez Gene)
WNT11GeneProduct485183 (Entrez Gene)
WNT1GeneProduct486560 (Entrez Gene)
WNT16GeneProduct612328 (Entrez Gene)
WNT2GeneProduct612141 (Entrez Gene)
WNT2BGeneProduct483220 (Entrez Gene)
WNT3GeneProduct609107 (Entrez Gene)
WNT3AGeneProduct482208 (Entrez Gene)
WNT4GeneProduct612367 (Entrez Gene)
WNT5AGeneProduct484721 (Entrez Gene)
WNT5BGeneProduct486756 (Entrez Gene)
WNT6GeneProduct488527 (Entrez Gene)
WNT7AGeneProduct607180 (Entrez Gene)
WNT7BGeneProduct481206 (Entrez Gene)

Annotated Interactions

No annotated interactions
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