Synthesis and Degradation of Ketone Bodies (Canis familiaris)

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Fatty acid beta-oxidationPyruvate metabolismGlycolysis(HMG-CoA cycle)Fatty acid metabolism* pathway-regulated enzymes: HMG-CoA synthase, mtSterol biosynthesisOXCT13-Hydroxy-3-methylglutaryl-CoABDH1HMGCS2HMGCLAcetoacetyl-CoAACAT13-Hydroxy-butyrateAcetyl-CoAAcetoacetateAcetyl-CoA


Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: Wikipedia


GenMAPP notes 
Ketogenesis (Human)
GenMAPP remarks 
Adapted from KEGG
This pathway was inferred from Homo sapiens pathway WP311(r21335) with a 55% conversion rate.

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68565view22:50, 5 July 2013MaintBotUpdated to 2013 gpml schema
67673view11:47, 26 June 2013DdiglesOntology Term : 'ketone bodies metabolic pathway' added !
48300view04:08, 18 May 2012KhanspersUpdating PubChem xrefs
48299view04:07, 18 May 2012MaintBotAutomatic update of PubChem xrefs
40723view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
35381view09:21, 12 February 2010Thomasadded literature, fixed metabolite xrefs
35371view09:15, 12 February 2010ThomasModified description
34002view18:38, 9 December 2009MaintBotAutomatic update of empty xrefs
30703view22:50, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
3-Hydroxy-3-methylglutaryl-CoAMetabolite1553-55-5 (CAS)
3-Hydroxy-butyrateMetabolite441 (PubChem-compound)
ACAT1GeneProduct489421 (Entrez Gene)
AcetoacetateMetabolite6971017 (PubChem-compound)
Acetoacetyl-CoAMetabolite1420-36-6 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
BDH1GeneProduct488037 (Entrez Gene)
HMGCLGeneProduct478187 (Entrez Gene)
HMGCS2GeneProduct607923 (Entrez Gene)
OXCT1GeneProduct479347 (Entrez Gene)

Annotated Interactions

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