Wnt Signaling Pathway and Pluripotency (Canis familiaris)

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632Stabilized beta-cateninPluripotencyTRIQ1Tcf/Lef-1Tcf/Lef-1Tcf/Lef-1+p+pTRTRbeta-catenin+pbeta-cateninPromotes PluripotencyTRRecruitment to UnknownUbiquitin Conjugating EnzymeWnt ReceptorsPhosphorylated beta-cateninTRPP2ABIODifferentiationTRCytoskeletonPromotes DifferentiationUbiquitin Taggedbeta-cateninNucleusFrizzled LigandsTR: Transcriptional RegulationProtein Kinase C51FZD8PPP2R2CPRKCEPRKCZWNT11CTBP1NFYANKD1PRKCIPPP2R2APRKD1PPP2R3BAXIN1TCF7L1LRP6FZD7MYCFRAT1WNT6SOX2PRKCQGSK3BFZD10FZD2LEF1TCF7PPP2R5CAPCNLKESRRBPPP2R1AWNT5BCD44WNT9BGrouchoPrkccMAPK10EP300PAFAH1B1LOC100855544MMP7LOC100855811WNT10BCTNNB1PPP2R3APPP2R1BFBXW226S Proteasome DegradationCTBP2LDLRWNT10AWNT3CREBBPRHOACCND1PPP2R2BDVL3PPP2CATCF7L2PPP2R4PPARDWNT3AWNT5ACCND2POU5F1MAP3K7TP53DVL2ZBTB33FZD4PRKCDWNT11FOXD3CCND3NKD2MAPK9WNT4FZD1PPP2CBPRKCARACGAP1PRKCHApoptosisWNT2FZD9CSNK1EWNT16PPP2R5EPLAUFOSL1CTNND1AXIN2WNT7AWNT1PRKCBWNT7BPPM1JWNT2BFZD6FZD3JUNLRP5NANOG


This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.

A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.


This pathway was inferred from Homo sapiens pathway WP399(r45007) with a 86% conversion rate.

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  1. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M; ''Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC
  2. Zhang X, Zhang J, Wang T, Esteban MA, Pei D; ''''; , PubMed Europe PMC
  3. Yi F, Pereira L, Merrill BJ; ''Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.''; Stem Cells, 2008 PubMed Europe PMC
  4. Pereira L, Yi F, Merrill BJ; ''Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.''; Mol Cell Biol, 2006 PubMed Europe PMC
  5. Sato N, Brivanlou AH; ''Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor.''; Methods Mol Biol, 2006 PubMed Europe PMC
  6. ''Kegg version of this pathway''; http://www.genome.jp/kegg/pathway/hsa/hsa04310.html,


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89927view13:35, 6 October 2016EgonwModified description
72127view07:51, 25 October 2013Mkutmonadded datasource to pathway nodes
70197view04:27, 13 July 2013MaintBotupdated to 2013 schema
48154view18:48, 9 May 2012MaintBotUpdating from human to fix xrefs
40659view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33951view18:21, 9 December 2009MaintBotAutomatic update of empty xrefs
32561view13:09, 17 August 2009MaintBotFixed text labels
32242view12:53, 15 August 2009MaintBotFixed text labels
31753view12:03, 14 August 2009MaintBotFixed group labels
31259view19:54, 13 August 2009MaintBotFixed text labels
30698view22:48, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
26S Proteasome DegradationPathwayWP183 (WikiPathways)
APCGeneProduct479139 (Entrez Gene)
AXIN1GeneProduct490099 (Entrez Gene)
AXIN2GeneProduct490903 (Entrez Gene)
ApoptosisPathwayWP254 (WikiPathways)
CCND1GeneProduct449028 (Entrez Gene)
CCND2GeneProduct611782 (Entrez Gene)
CCND3GeneProduct608847 (Entrez Gene)
CD44GeneProduct403939 (Entrez Gene)
CREBBPGeneProduct479866 (Entrez Gene)
CSNK1EGeneProduct474510 (Entrez Gene)
CTBP1GeneProduct612240 (Entrez Gene)
CTBP2GeneProduct100684514 (Entrez Gene)
CTNNB1GeneProduct477032 (Entrez Gene)
CTNND1GeneProduct483489 (Entrez Gene)
DVL2GeneProduct489464 (Entrez Gene)
DVL3GeneProduct478650 (Entrez Gene)
EP300GeneProduct100684945 (Entrez Gene)
ESRRBGeneProduct490798 (Entrez Gene)
FBXW2GeneProduct610990 (Entrez Gene)
FOSL1GeneProduct483724 (Entrez Gene)
FRAT1GeneProduct486819 (Entrez Gene)
FZD1GeneProduct482294 (Entrez Gene)
FZD2GeneProduct490937 (Entrez Gene)
FZD3GeneProduct486093 (Entrez Gene)
FZD4GeneProduct485149 (Entrez Gene)
FZD6GeneProduct403610 (Entrez Gene)
FZD7GeneProduct488478 (Entrez Gene)
FZD9GeneProduct489809 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
LDLRGeneProduct100683160 (Entrez Gene)
LEF1GeneProduct478507 (Entrez Gene)
LOC100855544GeneProduct100855544 (Entrez Gene)
LOC100855811GeneProduct100855811 (Entrez Gene)
LRP5GeneProduct100306933 (Entrez Gene)
LRP6GeneProduct477692 (Entrez Gene)
MAPK10GeneProduct478464 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MMP7GeneProduct489432 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
NKD1GeneProduct487288 (Entrez Gene)
NKD2GeneProduct488070 (Entrez Gene)
NLKGeneProduct491160 (Entrez Gene)
PAFAH1B1GeneProduct480656 (Entrez Gene)
PLAUGeneProduct403426 (Entrez Gene)
POU5F1GeneProduct481709 (Entrez Gene)
PPARDGeneProduct481756 (Entrez Gene)
PPP2CAGeneProduct403608 (Entrez Gene)
PPP2CBGeneProduct482873 (Entrez Gene)
PPP2R1AGeneProduct484335 (Entrez Gene)
PPP2R1BGeneProduct479444 (Entrez Gene)
PPP2R2AGeneProduct477374 (Entrez Gene)
PPP2R2BGeneProduct478053 (Entrez Gene)
PPP2R2CGeneProduct610262 (Entrez Gene)
PPP2R3AGeneProduct485672 (Entrez Gene)
PPP2R4GeneProduct491303 (Entrez Gene)
PPP2R5EGeneProduct480349 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCDGeneProduct494005 (Entrez Gene)
PRKCEGeneProduct609934 (Entrez Gene)
PRKCHGeneProduct490722 (Entrez Gene)
PRKCIGeneProduct478686 (Entrez Gene)
PRKCQGeneProduct478013 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PRKD1GeneProduct609091 (Entrez Gene)
RACGAP1GeneProduct486549 (Entrez Gene)
RHOAGeneProduct403954 (Entrez Gene)
SOX2GeneProduct488092 (Entrez Gene)
TCF7L1GeneProduct612070 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
WNT10AGeneProduct488528 (Entrez Gene)
WNT10BGeneProduct486561 (Entrez Gene)
WNT11GeneProduct485183 (Entrez Gene) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
WNT1GeneProduct486560 (Entrez Gene)
WNT2GeneProduct612141 (Entrez Gene)
WNT2BGeneProduct483220 (Entrez Gene)
WNT3GeneProduct609107 (Entrez Gene)
WNT3AGeneProduct482208 (Entrez Gene)
WNT4GeneProduct612367 (Entrez Gene)
WNT5AGeneProduct484721 (Entrez Gene)
WNT5BGeneProduct486756 (Entrez Gene)
WNT6GeneProduct488527 (Entrez Gene)
WNT7AGeneProduct607180 (Entrez Gene)
WNT7BGeneProduct481206 (Entrez Gene)
WNT9BGeneProduct490919 (Entrez Gene)
ZBTB33GeneProduct100685062 (Entrez Gene)

Annotated Interactions

No annotated interactions
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