Tryptophan metabolism (Canis familiaris)

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6-Hydroxyindolelactate2-FormylaminobenzaldehydeIndole-3-acetaldehydeIsophenoxazine5-HydroxykynurenamineIndole-3-acetaldoximeC011443-HydroxyanthranilateN-Acetylindoxyl3-Hydroxykynurenamine5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinateAnthranilate8-Methoxykynurenate5-(2'-Formylethyl)-4,6-dihydroxypicolinate3-MethoxyanthranilateIndole-3-acetate2-Oxoadipate4-(2-Aminophenyl)-2,4-dioxobutanoateQuinolinate3-Hydroxy-L-kynurenineKynurenate3-(2-Aminoethyl)-1H-indol-5-olIndole-3-ethanol2-AminomuconateCinnavalininateAnthranilate2-Formaminobenzoylacetate2-Oxoglutarate4,8-DihydroxyquinolineOxaloacetateL-Tryptophanyl-tRNA3-Methyldioxyindole5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolin6-Hydroxykynurenate5-Hydroxyindoleacetate5-HydroxyindolepyruvateFormylanthranilate7,8-Dihydroxykynurenate(Z)-5-Oxohex-2-enedioate7,8-Dihydro-7,8-dihydroxykynurenate5-Hydroxyindoleacetylglycine3-Indoleglycolaldehyde2-Aminomuconate2-Amino-3-carboxymuconateIndolepyruvate3-Methylindolepyruvate2,3-DihydroxyindoleIndolelactate4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoateGlucobrassicinBenzoate degradation via hydroxylationFormyl-5-hydroxykynurenamine5-MethoxyindoleacetateFormyl-N-acetyl-5-methoxykynurenamineALDH3A2ABP1HSD17B10CYP2C191.1.1.190ALDH9A1CATIDO1CYP1B1GCDHMAOBALDH1A26-HydroxymelatoninGlutaryl-CoA3-IndoleacetonitrileALDH2Cyp2c39PRMT11.14.16.34-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoatePRMT15-(2'-Carboxyethyl)-4,6-DihydroxypicolinateACMSDCYP2J21.5.1.-DDC2.6.1.27RNF251.13.99.3Acetyl-CoA1.1.1.1101.7.3.25-HydroxyindoleacetaldehydeCyp2d2ECHS1N-Methylserotonin2.6.1.274.2.1.842-AminophenolOGDHLOC100683688ACAT1KYNUCyp2b154.1.99.1CYP3A4RNF25WARSHAAOGlycolysis/Gluconeogenesis1.4.3.2Phenylalanine, Tyrosine and Tryptophan metabolismAcetoacetyl-CoAALDH21.13.12.3MDM2UBE3ADDCGCDHTDO2MAOBAANATCYP1A21.13.11.171.13.11.231.2.1.32IDO1CYP1A1CYP2E1MelatoninL-KynurenineMAOBMDM2ALDH1A14,6-Dihydroxyquinoline3.5.1.9CYP2A13Cyp2a2TryptamineN-Methyltryptamine1.14.13.9N-AcetylserotoninINMT4.1.1.-5-Hydroxy-L-tryptophanFormylkynurenineCYP4F12KYNUAldh1a4N-Acetylisatin3.5.1.4DHCR24Benzoate degradation via hydroxylation1.2.1.-DDCCyp2c12TPH1Nicotinate and nicotinamide metabolism3.2.1.147AADATL-TryptophanAADATCrotonoyl-CoA5-Hydroxykynurenine5-MethoxytryptamineIndole3.5.99.5CYP19A1AFMIDPRMT1Aldh1a44.1.1.43MAOBAOX11.14.99.2CYP7B12.1.1.491.10.3.4Cyp2a11.13.11.102.1.1.47ALDH1A2IDO1HADHKYNUALDH3A23.5.5.1LOC1006836881.2.3.73.5.1.491.1.1.1915-Hydroxy-N-formylkynurenineUBE3A2.6.1.27Indole-3-acetamideLOC612477Xanthurenic acidMDM21.14.16.-ALDH9A1UBR5ALDH1A11.3.1.181.13.11.-


Description

This pathway describes the metabolism of tryptophan, an essential amino acid. Original pathway was converted from rat to human using ortholog information. Edited by Sebastien Burel

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP465(r45056) with a 58% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
106044view11:56, 16 August 2019MaintBotHMDB identifier normalization
104909view19:18, 24 June 2019KhanspersModified description
104908view19:18, 24 June 2019Khanspersremoved genmapp comments
104822view12:57, 19 June 2019FehrhartModified description
85637view15:35, 4 June 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
71451view19:16, 17 October 2013MaintBotAutomated update of data sources
68501view21:45, 5 July 2013MaintBotUpdated to 2013 gpml schema
48151view18:46, 9 May 2012MaintBotUpdating from human to fix xrefs
40652view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33945view18:18, 9 December 2009MaintBotAutomatic update of empty xrefs
32559view13:08, 17 August 2009MaintBotFixed text labels
32240view12:52, 15 August 2009MaintBotFixed text labels
31750view12:03, 14 August 2009MaintBotFixed group labels
31257view19:53, 13 August 2009MaintBotFixed text labels
30695view22:47, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1.1.1.110GeneProduct
1.1.1.190GeneProduct
1.1.1.191GeneProduct
1.10.3.4GeneProduct
1.13.11.-GeneProduct
1.13.11.10GeneProduct
1.13.11.17GeneProduct
1.13.11.23GeneProduct
1.13.12.3GeneProduct
1.13.99.3GeneProduct
1.14.13.9GeneProduct
1.14.16.-GeneProduct
1.14.16.3GeneProduct
1.14.99.2GeneProduct
1.2.1.-GeneProduct
1.2.1.32GeneProduct
1.2.3.7GeneProduct
1.3.1.18GeneProduct
1.4.3.2GeneProduct
1.5.1.-GeneProduct
1.7.3.2GeneProduct
2-AminophenolMetabolite95-55-6 (CAS) 2-Aminophenol
2.1.1.47GeneProduct
2.1.1.49GeneProduct
2.6.1.27GeneProduct
3-IndoleacetonitrileMetabolite771-51-7 (CAS) 3-Indoleacetonitrile
3.2.1.147GeneProduct
3.5.1.4GeneProduct
3.5.1.49GeneProduct
3.5.1.9GeneProduct
3.5.5.1GeneProduct
3.5.99.5GeneProduct
4,6-DihydroxyquinolineMetaboliteHMDB0004077 (HMDB)
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoateMetaboliteHMDB0004083 (HMDB)
4.1.1.-GeneProduct
4.1.1.43GeneProduct
4.1.99.1GeneProduct
4.2.1.84GeneProduct
5-(2'-Carboxyethyl)-4,6-DihydroxypicolinateMetaboliteHMDB0006794 (HMDB)
5-Hydroxy-L-tryptophanMetaboliteHMDB0000472 (HMDB)
5-Hydroxy-N-formylkynurenineMetaboliteHMDB0004086 (HMDB)
5-HydroxyindoleacetaldehydeMetaboliteHMDB0004073 (HMDB)
5-HydroxykynurenineMetabolite484-78-6 (CAS)
5-MethoxytryptamineMetabolite608-07-1 (CAS)
6-HydroxymelatoninMetabolite2208-41-5 (CAS)
AADATGeneProduct486059 (Entrez Gene)
AANATGeneProduct483331 (Entrez Gene)
ABP1GeneProduct475536 (Entrez Gene)
ACAT1GeneProduct489421 (Entrez Gene)
ACMSDGeneProduct476125 (Entrez Gene)
AFMIDGeneProduct609011 (Entrez Gene)
ALDH1A1GeneProduct476323 (Entrez Gene)
ALDH1A2GeneProduct478319 (Entrez Gene)
ALDH2GeneProduct610941 (Entrez Gene)
ALDH3A2GeneProduct479518 (Entrez Gene)
ALDH9A1GeneProduct478991 (Entrez Gene)
AOX1GeneProduct608820 (Entrez Gene)
Acetoacetyl-CoAMetaboliteC00332 (KEGG Compound)
Acetyl-CoAMetabolite72-89-9 (CAS) Acetyl-CoA
Aldh1a4GeneProduct
Benzoate degradation via hydroxylationPathway
CATGeneProduct403474 (Entrez Gene)
CYP19A1GeneProduct494003 (Entrez Gene)
CYP1A1GeneProduct100686778 (Entrez Gene)
CYP1A2GeneProduct494010 (Entrez Gene)
CYP1B1GeneProduct483038 (Entrez Gene)
CYP2A13GeneProduct484494 (Entrez Gene)
CYP2C19GeneProduct415122 (Entrez Gene)
CYP2E1GeneProduct415128 (Entrez Gene)
CYP2J2GeneProduct610195 (Entrez Gene)
CYP3A4GeneProduct
CYP4F12GeneProduct
CYP7B1GeneProduct486973 (Entrez Gene)
Crotonoyl-CoAMetaboliteC00877 (KEGG Compound)
Cyp2a1GeneProduct
Cyp2a2GeneProduct
Cyp2b15GeneProduct
Cyp2c12GeneProduct
Cyp2c39GeneProduct
Cyp2d2GeneProduct
DDCGeneProduct606852 (Entrez Gene)
DHCR24GeneProduct489573 (Entrez Gene) predicted
ECHS1GeneProduct480828 (Entrez Gene)
FormylkynurenineMetabolite1022-31-7 (CAS) Formylkynurenine
GCDHGeneProduct476696 (Entrez Gene) predicted
Glutaryl-CoAMetaboliteC00527 (KEGG Compound)
Glycolysis/GluconeogenesisPathwayWP534 (WikiPathways)
HAAOGeneProduct611728 (Entrez Gene)
HADHGeneProduct478506 (Entrez Gene)
HSD17B10GeneProduct480930 (Entrez Gene)
IDO1GeneProduct475574 (Entrez Gene)
INMTGeneProduct
Indole-3-acetamideMetabolite879-37-8 (CAS) Indole-3-acetamide
IndoleMetabolite120-72-9 (CAS)
KYNUGeneProduct483907 (Entrez Gene)
L-KynurenineMetabolite343-65-7 (CAS) L-Kynurenine
L-TryptophanMetabolite73-22-3 (CAS)
LOC100683688GeneProduct100683688 (Entrez Gene)
LOC612477GeneProduct612477 (Entrez Gene)
MAOBGeneProduct403451 (Entrez Gene)
MDM2GeneProduct403693 (Entrez Gene)
MelatoninMetaboliteHMDB0001389 (HMDB)
N-AcetylisatinMetabolite574-17-4 (CAS) N-Acetylisatin
N-AcetylserotoninMetabolite1210-83-9 (CAS) N-Acetylserotonin
N-MethylserotoninMetaboliteHMDB0004369 (HMDB)
N-MethyltryptamineMetaboliteCHEBI:28136 (ChEBI)
Nicotinate and nicotinamide metabolismPathway
OGDHGeneProduct475499 (Entrez Gene)
PRMT1GeneProduct476411 (Entrez Gene)
Phenylalanine, Tyrosine and Tryptophan metabolismPathway
RNF25GeneProduct478912 (Entrez Gene)
TDO2GeneProduct475476 (Entrez Gene)
TPH1GeneProduct611956 (Entrez Gene)
TryptamineMetabolite61-54-1 (CAS)
UBE3AGeneProduct479010 (Entrez Gene)
UBR5GeneProduct475055 (Entrez Gene)
WARSGeneProduct480435 (Entrez Gene)
Xanthurenic acidMetaboliteHMDB0000881 (HMDB)

Annotated Interactions

No annotated interactions
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