Kit Receptor Signaling Pathway (Canis familiaris)

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TranslocationMitochondrionEnzyme complexECEndoplasmic reticulumMTCytoplasmDemethylationERAcetylationNUInhibitionDPM(Protein-protein interaction)ExtracellularDeubiquitinationDephosphorylationProteins in a complex interactionENDeacetylationDGlycosylationEndosomeAccession Number: NetPath 6; cellmap:6Golgi apparatusAutophosphorlationReceptorMolecule in the pathwayDesumoylationMethylationNucleusPlasma MembraneActivationPhosphorylationLigandCY->PMMolecular associationRecruitmentControlp85 complexProteolytic cleavageUbiquitinationGene SymbolCYSumoylationPalmitoylationGOReaction through unknown mechanisms/moleculesSTAT3STAT1FYNMAPK1PLCG1SPRED2HCKABL1YES1PRKCBPLCE1LYNJAK2SOS1DOK1CSF2RBSOCS5SHC1PIK3R2DOK1TRAILR1CRKCBLSTAT5ASTAT5BEP300RPS6KA1MPDZBADGRAPGRB2GRB10PTPN11GRB7RAF1STAP1EPORAKT1RASA1MATKSOCS1INPP5DVAV2PIK3R1KITLGPIK3CGMAP2K1TECPRKCAVAV1CLTCMITFSH3KBP1FGRFESKITSH2B2BTKSRCSPRED1KITLGCBLBCRKLCISHSOCS6SOCS4PTPRUKITPTPN6HRAS


Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath


GenMAPP notes 
NetPath 6; cellmap:6 - Kit Receptor Signaling Pathway. The Kit Receptor signaling pathway was kindly reviewed by Imke Ehlers in Peter Besmer’s lab. This cancer signaling pathway is available at Cancer Cell Map ( and NetPath ( and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (, PandeyLab at Johns Hopkins University ( and Institute of Bioinformatics ( If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks;
This pathway was inferred from Homo sapiens pathway WP304(r21319) with a 88% conversion rate.

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68577view23:03, 5 July 2013MaintBotUpdated to 2013 gpml schema
67424view10:59, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
40735view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35759view00:05, 13 February 2010AlexanderPico
32556view13:07, 17 August 2009MaintBotFixed text labels
31254view19:52, 13 August 2009MaintBotFixed text labels
30690view22:46, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ABL1GeneProduct491292 (Entrez Gene)
AKT1GeneProduct490878 (Entrez Gene)
BADGeneProduct483763 (Entrez Gene)
BTKGeneProduct492019 (Entrez Gene)
CBLBGeneProduct487965 (Entrez Gene)
CISHGeneProduct484757 (Entrez Gene)
CLTCGeneProduct480578 (Entrez Gene)
CRKLGeneProduct608125 (Entrez Gene)
CSF2RBGeneProduct481276 (Entrez Gene)
DOK1GeneProduct483100 (Entrez Gene)
EPORGeneProduct484943 (Entrez Gene)
FESGeneProduct609483 (Entrez Gene)
FGRGeneProduct487341 (Entrez Gene)
FYNGeneProduct475032 (Entrez Gene)
GRAPGeneProduct489534 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GRB7GeneProduct491021 (Entrez Gene)
HCKGeneProduct485828 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
KITGeneProduct403811 (Entrez Gene)
KITLGGeneProduct403507 (Entrez Gene)
LYNGeneProduct477886 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MATKGeneProduct611999 (Entrez Gene)
MITFGeneProduct415126 (Entrez Gene)
MPDZGeneProduct474708 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PLCE1GeneProduct486808 (Entrez Gene)
PLCG1GeneProduct485874 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
PTPN6GeneProduct486717 (Entrez Gene)
PTPRUGeneProduct487328 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RASA1GeneProduct479158 (Entrez Gene)
RPS6KA1GeneProduct487353 (Entrez Gene)
SH2B2GeneProduct489820 (Entrez Gene)
SH3KBP1GeneProduct612797 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS5GeneProduct474581 (Entrez Gene)
SOCS6GeneProduct476171 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
SPRED1GeneProduct487485 (Entrez Gene)
SPRED2GeneProduct481397 (Entrez Gene)
SRCGeneProduct485864 (Entrez Gene)
STAP1GeneProduct482171 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
TECGeneProduct482140 (Entrez Gene)
VAV1GeneProduct485016 (Entrez Gene)
VAV2GeneProduct608060 (Entrez Gene)
YES1GeneProduct490532 (Entrez Gene)

Annotated Interactions

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