TCA Cycle (Canis familiaris)

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CytosolMitochondrionDegradation of Fatty AcidsContaining an Odd Number of CarbonsGlycolysisFatty Acid SynthesisElectron Transport ChainGluconeogenesisDegradation of Fatty AcidsContaining an Even Number of CarbonsPDHXPDP1OxaloacetateMDH1FumarateSDHCMalatePDHBSuccinatePDP2PDK2SUCLG2IDH3GFHSDHAIDH3ADLSTPDHA1SUCLA2SUCLG1PDHA2PDK1DLDDLATCSIsocitrateMDH2PDK4LOC479438OGDHOxaloacetateIDH2PCACO2DLDPyruvateSuccinyl-CoAMalatePDK3alpha-KetoglutarateIDH3BCitrateSDHBAcetyl-CoA


The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both Albert Szent-Gyorgyi and Hans Krebs. [From Wikipedia]


This pathway was inferred from Homo sapiens pathway WP78(r28870) with a 93% conversion rate.

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106040view11:56, 16 August 2019MaintBotHMDB identifier normalization
87711view09:11, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
87710view09:10, 25 July 2016MirellaKalafatiOntology Term : 'citric acid cycle pathway' added !
68560view22:45, 5 July 2013MaintBotUpdated to 2013 gpml schema
40718view21:52, 1 March 2011MaintBotRemoved redundant pathway information and comments
33997view18:37, 9 December 2009MaintBotAutomatic update of empty xrefs
32552view13:06, 17 August 2009MaintBotFixed text labels
32234view12:50, 15 August 2009MaintBotFixed text labels
31741view12:00, 14 August 2009MaintBotFixed group labels
31250view19:51, 13 August 2009MaintBotFixed text labels
30684view22:44, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ACO2GeneProduct474487 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
CSGeneProduct474403 (Entrez Gene)
CitrateMetaboliteHMDB0000094 (HMDB)
DLATGeneProduct489406 (Entrez Gene)
DLDGeneProduct403978 (Entrez Gene)
DLSTGeneProduct480388 (Entrez Gene)
FHGeneProduct480092 (Entrez Gene)
FumarateMetaboliteHMDB0000134 (HMDB)
IDH2GeneProduct479043 (Entrez Gene)
IDH3AGeneProduct479066 (Entrez Gene)
IDH3BGeneProduct477177 (Entrez Gene)
IDH3GGeneProduct481081 (Entrez Gene)
IsocitrateMetaboliteHMDB0000193 (HMDB)
LOC479438GeneProduct479438 (Entrez Gene)
MDH1GeneProduct474614 (Entrez Gene)
MDH2GeneProduct482945 (Entrez Gene)
MalateMetaboliteHMDB0000156 (HMDB)
OGDHGeneProduct475499 (Entrez Gene)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
PCGeneProduct483704 (Entrez Gene)
PDHA1GeneProduct480858 (Entrez Gene)
PDHBGeneProduct476574 (Entrez Gene)
PDHXGeneProduct475942 (Entrez Gene)
PDK1GeneProduct476828 (Entrez Gene)
PDK2GeneProduct491075 (Entrez Gene)
PDK3GeneProduct480868 (Entrez Gene)
PDK4GeneProduct482310 (Entrez Gene)
PDP1GeneProduct477941 (Entrez Gene)
PDP2GeneProduct489771 (Entrez Gene)
PyruvateMetaboliteHMDB0000243 (HMDB)
SDHAGeneProduct478634 (Entrez Gene)
SDHBGeneProduct608210 (Entrez Gene)
SDHCGeneProduct478983 (Entrez Gene)
SUCLA2GeneProduct485448 (Entrez Gene)
SUCLG1GeneProduct475775 (Entrez Gene)
SUCLG2GeneProduct476562 (Entrez Gene)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)

Annotated Interactions

No annotated interactions
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