MAPK Signaling Pathway (Canis familiaris)

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Scaffold1-7, 9, 11108LegendActivating mutationCalcium channelsHeteromeric G-proteinCalcium channelsProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKTRAF6MEF2CPSRFRPS6KA3PMAP2K3PELK4PRAP1APCRKIL1APDGFBAKT3ECSITMAP3K13RASGRP4MAP3K7PMAPK9PGRB2MKNK1PDUSP1STMN1PELK1PPPEGFRPPP3CBPPP3CCMAP4K1NFATC1PARRB2MAPTPRASGRP1RAP1BPCD14IKBKGBDNFDAXXMAPK10PTNFMOSSTK4MAPK14PIKBKBPPARRB1LRRK2CASP3FLNAPRKACAMAPKAPK2PTNFRSF1AMAP3K14HSPB1PMAP3K20GNA12TGFB1MAP3K1PMAP3K2PMAXPDUSP10RASGRF2MAP4K4PDGFRBTAB1MAP3K4GADD45AWnt signaling pathwayMAP2K5CDC25BPIL1R1RAC2PRKCDPPP5CMAP2K1PPRAC1PTPN7IL1R2TAB2TGFBR1MAPK1PPPTPRRPTPN5PLA2G4DPBRAFNTRK1ATF2PMAP2K4PLPSFOSPRKCGMYCSOS2TGFB2ELK1PMAPK7PDUSP4CACNG3ApoptosisHSPA8MAPK12PMAPK8IP1IP3PPM1ACa2+IL1BELK4PTRAF2MAPK13PTAOK1MAP2K6PDUSP8AKT2MAPKAPK5PRASA2DUSP7PPP3R2FGFR1TGFB3PPP3CAEGFDDIT3PMAP3K6MAP3K8NGFCRKLTAOK2cAMPMAPK3PPMAPK8PNR4A1PCell cyclePRKCAATF4PNTF4PDGFAATF4PNTRK2FASLGPDGFRBPPM1BFGFR2CDC42FGFR3LAMTOR3FGFR4JUNPPJUNDSOS1PHRASRRASPPRPS6KA5PMAP3K12TP53PRRAS2PNFKB1GNG12PLA2G4CPNF1RASGRP2AKT1p53 signaling pathwayRASGRP3RASGRP4RASA1RASGRF1HSPA6Ca2+NTF3RAPGEF2Phosphatidylinositolsignaling systemPRKACBHSPA1APRKACGSTK3DUSP3MAP4K3CHUKPTGFBR2NFKB2MAP4K2RELAMAP2K7PRELBPPP3R1DUSP9NLKPDUSP2DAGDUSP16FASMKNK2PPLA2G4APNFATC3PMAP3K5PMAP3K11PTAOK3DUSP6MAP2K2PPPPP5D1MAPK11PRPS6KA4PMAPKAPK3PRAC3MAPK8IP2MAPK8IP3FLNBFLNCHSPA1BHSPA1LHSPA2MRASPNRASPKRASPRAF1PPLA2G4FPPLA2G4BPLA2G4EPPCACNG2CACNG5CACNG4CACNA2D3CACNG8CACNG7CACNG6CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1SCACNA2D1CACNB1CACNB2CACNB3CACNB4CACNG1CACNA1ICACNA1HCACNA1GCACNA2D2CACNA2D4FGF4FGF1FGF2FGF3FGF4FGF5FGF6FGF7FGF8FGF9FGF10FGF11FGF12FGF13FGF14FGF20FGF21FGF22FGF23FGF18FGF17FGF16FGF19Fibroblast growth factorsFibroblast growthfactorsPAK2PAK1


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP382 (r95114) with a 94.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  2. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  3. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  4. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  5. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  6. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  7. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  8. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC
  9. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  10. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  11. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106039view11:56, 16 August 2019MaintBotHMDB identifier normalization
105691view21:02, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96392view09:52, 12 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95778view14:33, 19 January 2018MkutmonHomology conversion update
72089view21:25, 24 October 2013Mkutmonadded datasource for "Wnt signaling pathway", "Apoptosis" and "Cell cycle"
68578view23:04, 5 July 2013MaintBotUpdated to 2013 gpml schema
67440view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
48169view20:31, 9 May 2012MaintBotUpdating from human to fix xrefs
40736view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35663view22:26, 12 February 2010KhanspersDescription and lit refs
34012view18:42, 9 December 2009MaintBotAutomatic update of empty xrefs
32551view13:06, 17 August 2009MaintBotFixed text labels
32233view12:50, 15 August 2009MaintBotFixed text labels
31740view12:00, 14 August 2009MaintBotFixed group labels
31249view19:51, 13 August 2009MaintBotFixed text labels
30683view22:44, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSCAFG00000018354 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:207
AKT2GeneProductENSCAFG00000005388 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:208
AKT3GeneProductENSCAFG00000015806 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10000
ARRB1GeneProductENSCAFG00000005415 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:408
ARRB2GeneProductENSCAFG00000015905 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:409
ATF2GeneProductENSCAFG00000013332 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1386
ATF4GeneProductENSCAFG00000001324 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:468
ApoptosisPathwayWP254 (WikiPathways)
BDNFGeneProductENSCAFG00000010207 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:627
BRAFGeneProductENSCAFG00000003907 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:673
CACNA1AGeneProductENSCAFG00000016897 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000141837
CACNA1BGeneProductENSCAFG00000019380 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000148408
CACNA1CGeneProductENSCAFG00000016051 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000151067
CACNA1DGeneProductENSCAFG00000008525 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000157388
CACNA1EGeneProductENSCAFG00000013004 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000198216
CACNA1FGeneProductENSCAFG00000015873 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102001
CACNA1GGeneProductENSCAFG00000017120 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000006283
CACNA1HGeneProductENSCAFG00000019596 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196557
CACNA1IGeneProductENSCAFG00000001314 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000100346
CACNA1SGeneProductENSCAFG00000010884 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000081248
CACNA2D1GeneProductENSCAFG00000006339 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000153956
CACNA2D2GeneProductENSCAFG00000010431 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000007402
CACNA2D3GeneProductENSCAFG00000008211 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000157445
CACNA2D4GeneProductNo homologues found for original id En:ENSG00000151062
CACNB1GeneProductENSCAFG00000016510 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000067191
CACNB2GeneProductENSCAFG00000004474 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000165995
CACNB3GeneProductENSCAFG00000008857 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000167535
CACNB4GeneProductENSCAFG00000005773 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000182389
CACNG1GeneProductENSCAFG00000011372 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000108878
CACNG2GeneProductENSCAFG00000029809 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000166862
CACNG3GeneProductENSCAFG00000017571 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = H:CACNG3
CACNG4GeneProductNo homologues found for original id En:ENSG00000075461
CACNG5GeneProductENSCAFG00000031724 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000075429
CACNG6GeneProductENSCAFG00000002704 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000130433
CACNG7GeneProductENSCAFG00000002705 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000105605
CACNG8GeneProductENSCAFG00000032667 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000142408
CASP3GeneProductENSCAFG00000007750 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:836
CD14GeneProductNo homologues found for original id L:929
CDC25BGeneProductENSCAFG00000006175 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:994
CDC42GeneProductENSCAFG00000014707 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:998
CHUKGeneProductENSCAFG00000009588 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000213341
CRKGeneProductENSCAFG00000019157 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1398
CRKLGeneProductENSCAFG00000015188 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1399
Ca2+MetaboliteHMDB0000464 (HMDB)
Cell cyclePathwayWP179 (WikiPathways)
DAGMetaboliteCHEBI:18035 (ChEBI)
DAXXGeneProductENSCAFG00000000981 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1616
DDIT3GeneProductENSCAFG00000030112 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1649
DUSP10GeneProductENSCAFG00000013641 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11221
DUSP16GeneProductENSCAFG00000013274 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000111266
DUSP1GeneProductENSCAFG00000029826 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1843
DUSP2GeneProductENSCAFG00000023317 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158050
DUSP3GeneProductENSCAFG00000028570 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000108861
DUSP4GeneProductENSCAFG00000030240 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1846
DUSP6GeneProductENSCAFG00000006100 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1848
DUSP7GeneProductENSCAFG00000032027 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1849
DUSP8GeneProductENSCAFG00000010009 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000184545
DUSP9GeneProductENSCAFG00000019241 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000130829
ECSITGeneProductENSCAFG00000017334 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51295
EGFGeneProductENSCAFG00000011532 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1950
EGFRGeneProductENSCAFG00000003465 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1956
ELK1GeneProductENSCAFG00000015178 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2002
ELK4GeneProductENSCAFG00000010144 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158711
FASGeneProductENSCAFG00000015712 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:355
FASLGGeneProductENSCAFG00000014678 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:356
FGF10GeneProductENSCAFG00000032695 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000070193
FGF11GeneProductENSCAFG00000028562 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000161958
FGF12GeneProductENSCAFG00000031187 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000114279
FGF13GeneProductENSCAFG00000032672 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000129682
FGF14GeneProductENSCAFG00000005926 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102466
FGF16GeneProductENSCAFG00000029141 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196468
FGF17GeneProductENSCAFG00000009749 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000158815
FGF18GeneProductENSCAFG00000016903 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000156427
FGF19GeneProductENSCAFG00000010693 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000162344
FGF1GeneProductENSCAFG00000031965 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000113578
FGF20GeneProductENSCAFG00000006845 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000078579
FGF21GeneProductENSCAFG00000003904 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000105550
FGF22GeneProductENSCAFG00000019707 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000070388
FGF23GeneProductENSCAFG00000015365 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000118972
FGF2GeneProductENSCAFG00000003996 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138685
FGF3GeneProductENSCAFG00000010688 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000186895
FGF4GeneProductENSCAFG00000029983 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000075388
FGF5GeneProductENSCAFG00000008886 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138675
FGF6GeneProductENSCAFG00000015361 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000111241
FGF7GeneProductENSCAFG00000014923 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000140285
FGF8GeneProductENSCAFG00000009918 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000107831
FGF9GeneProductENSCAFG00000029890 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000102678
FGFR1GeneProductENSCAFG00000005970 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2260
FGFR2GeneProductENSCAFG00000012374 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000066468
FGFR3GeneProductENSCAFG00000014993 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000068078
FGFR4GeneProductENSCAFG00000016518 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000160867
FLNAGeneProductENSCAFG00000019521 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2316
FLNBGeneProductENSCAFG00000007603 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000136068
FLNCGeneProductENSCAFG00000001585 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000128591
FOSGeneProductENSCAFG00000017040 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2353
GADD45AGeneProductENSCAFG00000029474 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1647
GNA12GeneProductENSCAFG00000029596 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2768
GNG12GeneProductENSCAFG00000028654 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000172380
GRB2GeneProductENSCAFG00000030297 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:2885
HRASGeneProductENSCAFG00000031029 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000174775
HSPA1AGeneProductNo homologues found for original id L:3303
HSPA1BGeneProductNo homologues found for original id En:ENSG00000204388
HSPA1LGeneProductENSCAFG00000000639 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000204390
HSPA2GeneProductENSCAFG00000016031 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000126803
HSPA6GeneProductNo homologues found for original id En:ENSG00000173110
HSPA8GeneProductENSCAFG00000001886 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3312
HSPB1GeneProductENSCAFG00000013544 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3315
IKBKBGeneProductENSCAFG00000005526 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3551
IKBKGGeneProductENSCAFG00000019605 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8517
IL1AGeneProductENSCAFG00000007245 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3552
IL1BGeneProductENSCAFG00000007249 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3553
IL1R1GeneProductENSCAFG00000002147 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3554
IL1R2GeneProductENSCAFG00000002152 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7850
IP3MetaboliteCHEBI:16595 (ChEBI)
JUNDGeneProductENSCAFG00000023338 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3727
JUNGeneProductENSCAFG00000018897 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3725
KRASGeneProductENSCAFG00000011428 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3845
LAMTOR3GeneProductENSCAFG00000029975 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8649
LPSMetaboliteCHEBI:16412 (ChEBI)
LRRK2GeneProductENSCAFG00000009926 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000188906
MAP2K1GeneProductENSCAFG00000017298 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5604
MAP2K2GeneProductENSCAFG00000019138 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5605
MAP2K3GeneProductENSCAFG00000018530 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5606
MAP2K4GeneProductENSCAFG00000017851 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6416
MAP2K5GeneProductENSCAFG00000017454 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5607
MAP2K6GeneProductENSCAFG00000010758 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5608
MAP2K7GeneProductENSCAFG00000031522 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5609
MAP3K11GeneProductENSCAFG00000013415 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4296
MAP3K12GeneProductENSCAFG00000006918 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7786
MAP3K13GeneProductENSCAFG00000013230 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9175
MAP3K14GeneProductENSCAFG00000013774 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000006062
MAP3K1GeneProductENSCAFG00000006917 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4214
MAP3K20GeneProductENSCAFG00000013140 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51776
MAP3K2GeneProductENSCAFG00000004528 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10746
MAP3K4GeneProductENSCAFG00000000760 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4216
MAP3K5GeneProductENSCAFG00000000251 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4217
MAP3K6GeneProductENSCAFG00000012144 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9064
MAP3K7GeneProductENSCAFG00000003123 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6885
MAP3K8GeneProductENSCAFG00000003980 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1326
MAP4K1GeneProductENSCAFG00000005874 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:11184
MAP4K2GeneProductENSCAFG00000014216 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000168067
MAP4K3GeneProductENSCAFG00000006426 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8491
MAP4K4GeneProductENSCAFG00000002162 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9448
MAPK10GeneProductENSCAFG00000009396 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5602
MAPK11GeneProductNo homologues found for original id En:ENSG00000185386
MAPK12GeneProductENSCAFG00000000685 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6300
MAPK13GeneProductENSCAFG00000001382 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5603
MAPK14GeneProductENSCAFG00000001378 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:1432
MAPK1GeneProductENSCAFG00000015421 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5594
MAPK3GeneProductENSCAFG00000018974 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5595
MAPK7GeneProductENSCAFG00000018202 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5598
MAPK8GeneProductENSCAFG00000006551 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5599
MAPK8IP1GeneProductENSCAFG00000009363 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000121653
MAPK8IP2GeneProductENSCAFG00000000568 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000008735
MAPK8IP3GeneProductENSCAFG00000019513 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000138834
MAPK9GeneProductENSCAFG00000000395 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5601
MAPKAPK2GeneProductENSCAFG00000011432 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9261
MAPKAPK3GeneProductENSCAFG00000010281 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000114738
MAPKAPK5GeneProductENSCAFG00000008745 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8550
MAPTGeneProductENSCAFG00000013670 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4137
MAXGeneProductENSCAFG00000016212 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4149
MEF2CGeneProductENSCAFG00000008302 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4208
MKNK1GeneProductENSCAFG00000004205 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:8569
MKNK2GeneProductENSCAFG00000019429 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000099875
MOSGeneProductENSCAFG00000007046 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4342
MRASGeneProductENSCAFG00000007541 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:22808
MYCGeneProductENSCAFG00000001086 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4609
NF1GeneProductENSCAFG00000018592 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000196712
NFATC1GeneProductENSCAFG00000000011 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4772
NFATC3GeneProductENSCAFG00000020324 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000072736
NFKB1GeneProductENSCAFG00000010730 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4790
NFKB2GeneProductENSCAFG00000010155 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000077150
NGFGeneProductENSCAFG00000009739 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000134259
NLKGeneProductENSCAFG00000018650 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:51701
NR4A1GeneProductENSCAFG00000007338 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3164
NRASGeneProductENSCAFG00000009532 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4893
NTF3GeneProductENSCAFG00000015278 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000185652
NTF4GeneProductENSCAFG00000003838 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000225950
NTRK1GeneProductENSCAFG00000016528 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:4914
NTRK2GeneProductENSCAFG00000001380 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000148053
PAK1GeneProductENSCAFG00000004956 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5058
PAK2GeneProductENSCAFG00000013067 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5062
PDGFAGeneProductENSCAFG00000011193 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000197461
PDGFBGeneProductENSCAFG00000001356 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5155
PDGFRBGeneProductENSCAFG00000018214 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000113721
PLA2G4AGeneProductENSCAFG00000013778 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000116711
PLA2G4BGeneProductENSCAFG00000009735 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000243708
PLA2G4CGeneProductNo homologues found for original id En:ENSG00000105499
PLA2G4DGeneProductENSCAFG00000024815 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000159337
PLA2G4EGeneProductENSCAFG00000024908 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000188089
PLA2G4FGeneProductENSCAFG00000009914 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000168907
PPM1AGeneProductENSCAFG00000015603 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5494
PPM1BGeneProductENSCAFG00000002535 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5495
PPP3CAGeneProductENSCAFG00000010644 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5530
PPP3CBGeneProductENSCAFG00000014818 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5532
PPP3CCGeneProductENSCAFG00000009390 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5533
PPP3R1GeneProductNo homologues found for original id L:5534
PPP3R2GeneProductNo homologues found for original id L:5535
PPP5CGeneProductENSCAFG00000004313 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5536
PPP5D1GeneProductNo homologues found for original id En:ENSG00000230510
PRKACAGeneProductENSCAFG00000016488 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5566
PRKACBGeneProductENSCAFG00000020319 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000142875
PRKACGGeneProductNo homologues found for original id En:ENSG00000165059
PRKCAGeneProductENSCAFG00000011326 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000154229
PRKCDGeneProductENSCAFG00000008689 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5580
PRKCGGeneProductENSCAFG00000002713 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5582
PTPN5GeneProductENSCAFG00000009391 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:84867
PTPN7GeneProductENSCAFG00000010591 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5778
PTPRRGeneProductENSCAFG00000023742 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5801
Phosphatidylinositol signaling systemPathway
RAC1GeneProductENSCAFG00000015716 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5879
RAC2GeneProductENSCAFG00000001508 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5880
RAC3GeneProductNo homologues found for original id En:ENSG00000169750
RAF1GeneProductENSCAFG00000004951 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5894
RAP1AGeneProductENSCAFG00000013686 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5906
RAP1BGeneProductNo homologues found for original id L:5908
RAPGEF2GeneProductENSCAFG00000008719 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000109756
RASA1GeneProductENSCAFG00000008410 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5921
RASA2GeneProductENSCAFG00000007674 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5922
RASGRF1GeneProductENSCAFG00000014053 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000058335
RASGRF2GeneProductENSCAFG00000008744 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:5924
RASGRP1GeneProductENSCAFG00000008674 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10125
RASGRP2GeneProductENSCAFG00000014309 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000068831
RASGRP3GeneProductENSCAFG00000005870 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000152689
RASGRP4GeneProductENSCAFG00000005909 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000171777
RELAGeneProductENSCAFG00000013334 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000173039
RELBGeneProductENSCAFG00000004597 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000104856
RPS6KA3GeneProductENSCAFG00000013171 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6197
RPS6KA4GeneProductENSCAFG00000031793 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000162302
RPS6KA5GeneProductENSCAFG00000017543 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9252
RRAS2GeneProductENSCAFG00000008396 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000133818
RRASGeneProductENSCAFG00000003604 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000126458
SOS1GeneProductENSCAFG00000006340 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000115904
SOS2GeneProductENSCAFG00000014275 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6655
SRFGeneProductENSCAFG00000001829 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6722
STK3GeneProductENSCAFG00000000484 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:6788
STK4GeneProductENSCAFG00000009615 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000101109
STMN1GeneProductENSCAFG00000029191 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:3925
TAB1GeneProductENSCAFG00000001332 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:10454
TAB2GeneProductENSCAFG00000000373 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:23118
TAOK1GeneProductENSCAFG00000018898 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:57551
TAOK2GeneProductENSCAFG00000017039 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:9344
TAOK3GeneProductENSCAFG00000009924 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000135090
TGFB1GeneProductENSCAFG00000005014 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7040
TGFB2GeneProductENSCAFG00000010815 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7042
TGFB3GeneProductENSCAFG00000017101 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7043
TGFBR1GeneProductENSCAFG00000002528 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7046
TGFBR2GeneProductENSCAFG00000005449 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7048
TNFGeneProductENSCAFG00000000517 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7124
TNFRSF1AGeneProductENSCAFG00000015197 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = En:ENSG00000067182
TP53GeneProductENSCAFG00000016714 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7157
TRAF2GeneProductENSCAFG00000019541 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7186
TRAF6GeneProductENSCAFG00000006813 (Ensembl) Homology Mapping from Homo sapiens to Canis familiaris: Original ID = L:7189
Wnt signaling pathwayPathwayWP428 (WikiPathways)
cAMPMetaboliteHMDB0000058 (HMDB)
p53 signaling pathwayPathway

Annotated Interactions

No annotated interactions
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