ActivationMAPKsMitochondrionTranscription Initiation Factors (TIFs)IKKs+pRNA Pol IITFIIDTranslocation+pERETFIIFTFIIAInhibitionTATA Box bindingproteinGene expressionanti apoptosisTIFsNucleusTFIIERNA polymerase II+pGene expression(anti apoptotic)TFIIBHDACsTFIIHHistone Deacetylases (HDACs)POLR2AGTF2H2ILKCREB1BCL2ESR1MAPK1GTF2H4EstradiolGRB2RASTBPCDK7TAF9GPERQ1HG71_CANFAESR1POLR2GMAPK14NFKB1EstradiolJUNSRCPOLR2KESR1POLR2IPRKACAGTF2A2GTF2F2SIN3ABCL2POLR2EEstradiolCREBBPSHC2ESR1GNGT1AKT1ELK1LOC487309GTF2H1MNAT1GTF2E2GTF2E1p300ESR1LOC607662EstradiolCyclic AMPCREB1LOC480957EstradiolLOC478040ESR1SP1POLR2CERCC2ESR1ESR1POLR2JTAF6POLR2FTAF12CHUKERCC3TAF5POLR2HCCNHFOSESR1BRCA1LOC490941IKBKBPIK3CAGTF2A2EstradiolCCND1IKBKGTBPLOC480907EstradiolGNASPOLR2BTAF13BRAFEstradiolGTF2BTAF7LOC475035LOC486589MAPK9NFKB1GNB1NCOR1GTF2H3SOS1Estradiol