Estrogen signaling (Canis familiaris)

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ActivationMAPKsMitochondrionTranscription Initiation Factors (TIFs)IKKs+pRNA Pol IITFIIDTranslocation+pERETFIIFTFIIAInhibitionTATA Box bindingproteinGene expressionanti apoptosisTIFsNucleusTFIIERNA polymerase II+pGene expression(anti apoptotic)TFIIBHDACsTFIIHHistone Deacetylases (HDACs)POLR2AGTF2H2ILKCREB1BCL2ESR1MAPK1GTF2H4EstradiolGRB2RASTBPCDK7TAF9GPERQ1HG71_CANFAESR1POLR2GMAPK14NFKB1EstradiolJUNSRCPOLR2KESR1POLR2IPRKACAGTF2A2GTF2F2SIN3ABCL2POLR2EEstradiolCREBBPSHC2ESR1GNGT1AKT1ELK1LOC487309GTF2H1MNAT1GTF2E2GTF2E1p300ESR1LOC607662EstradiolCyclic AMPCREB1LOC480957EstradiolLOC478040ESR1SP1POLR2CERCC2ESR1ESR1POLR2JTAF6POLR2FTAF12CHUKERCC3TAF5POLR2HCCNHFOSESR1BRCA1LOC490941IKBKBPIK3CAGTF2A2EstradiolCCND1IKBKGTBPLOC480907EstradiolGNASPOLR2BTAF13BRAFEstradiolGTF2BTAF7LOC475035LOC486589MAPK9NFKB1GNB1NCOR1GTF2H3SOS1Estradiol


Description

Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP712(r29739) with a 91% conversion rate.

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Ontology Terms

 

Bibliography

  1. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.''; J Leukoc Biol, 2008 PubMed Europe PMC
  2. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC
  3. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.''; J Biol Chem, 2006 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
90717view20:21, 13 December 2016KhanspersModified title
88035view13:35, 25 July 2016SusanOntology Term : 'estrogen signaling pathway' added !
74171view14:53, 2 April 2014EgonwUpdated the PubChem-compound data source.
68511view21:55, 5 July 2013MaintBotUpdated to 2013 gpml schema
58841view23:33, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40663view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
33955view18:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32547view13:05, 17 August 2009MaintBotFixed text labels
32228view12:48, 15 August 2009MaintBotFixed text labels
31730view11:57, 14 August 2009MaintBotFixed group labels
31245view19:50, 13 August 2009MaintBotFixed text labels
30673view22:41, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
BCL2GeneProduct403416 (Entrez Gene)
BRAFGeneProduct475526 (Entrez Gene)
BRCA1GeneProduct403437 (Entrez Gene)
CCND1GeneProduct449028 (Entrez Gene)
CCNHGeneProduct479156 (Entrez Gene)
CDK7GeneProduct608441 (Entrez Gene)
CHUKGeneProductENSCAFG00000009588 (Ensembl)
CREB1GeneProduct607922 (Entrez Gene)
CREBBPGeneProduct479866 (Entrez Gene)
Cyclic AMPMetabolite6076 (PubChem-compound)
ELK1GeneProduct491860 (Entrez Gene)
ERCC2GeneProduct493995 (Entrez Gene)
ERCC3GeneProduct476105 (Entrez Gene)
ESR1GeneProduct403640 (Entrez Gene)
EstradiolMetabolite5757 (PubChem-compound)
FOSGeneProduct490792 (Entrez Gene)
GNASGeneProduct403943 (Entrez Gene)
GNB1GeneProduct403912 (Entrez Gene)
GNGT1GeneProduct403895 (Entrez Gene)
GPERGeneProduct480808 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
GTF2A2GeneProduct478327 (Entrez Gene)
GTF2BGeneProduct479960 (Entrez Gene)
GTF2E1GeneProduct488002 (Entrez Gene)
GTF2E2GeneProduct475597 (Entrez Gene)
GTF2F2GeneProduct609164 (Entrez Gene)
GTF2H1GeneProduct476881 (Entrez Gene)
GTF2H2GeneProduct478089 (Entrez Gene)
GTF2H3GeneProduct477446 (Entrez Gene)
GTF2H4GeneProduct606988 (Entrez Gene)
IKBKBGeneProductENSCAFG00000005526 (Ensembl)
IKBKGGeneProductENSCAFG00000019605 (Ensembl)
ILKGeneProduct476836 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
LOC475035GeneProduct475035 (Entrez Gene) HDAC2; histone deacetylase 2
LOC478040GeneProduct478040 (Entrez Gene) HDAC3; histone deacetylase 3
LOC480907GeneProduct480907 (Entrez Gene) HDAC6; histone deacetylase 6
LOC480957GeneProduct480957 (Entrez Gene) HDAC8; histone deacetylase
LOC486589GeneProduct486589 (Entrez Gene) HDAC7A; histone deacetylase 7
LOC487309GeneProduct487309 (Entrez Gene) HDAC1; histone deacetylase 1
LOC490941GeneProduct490941 (Entrez Gene) HDAC5; histone deacetylase 5
LOC607662GeneProduct607662 (Entrez Gene) HDAC4; histone deacetylase 4
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProductENSCAFG00000015421 (Ensembl)
MAPK9GeneProduct474652 (Entrez Gene)
MNAT1GeneProduct480346 (Entrez Gene)
NCOR1GeneProduct479515 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
POLR2AGeneProduct479483 (Entrez Gene)
POLR2BGeneProduct475152 (Entrez Gene)
POLR2CGeneProduct478109 (Entrez Gene)
POLR2EGeneProduct611859 (Entrez Gene)
POLR2FGeneProduct474512 (Entrez Gene)
POLR2GGeneProduct476052 (Entrez Gene)
POLR2HGeneProduct478656 (Entrez Gene)
POLR2IGeneProduct476476 (Entrez Gene)
POLR2JGeneProduct
POLR2KGeneProduct
PRKACAGeneProduct403556 (Entrez Gene)
Q1HG71_CANFAGeneProductENSCAFG00000017298 (Ensembl)
RASGeneProduct
SHC2GeneProduct611955 (Entrez Gene)
SIN3AGeneProduct478372 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
SP1GeneProduct486507 (Entrez Gene)
SRCGeneProduct485864 (Entrez Gene)
TAF12GeneProduct
TAF13GeneProduct476973 (Entrez Gene)
TAF5GeneProduct
TAF6GeneProduct489846 (Entrez Gene)
TAF7GeneProduct487180 (Entrez Gene)
TAF9GeneProduct480815 (Entrez Gene)
TBPGeneProduct611193 (Entrez Gene)
p300GeneProduct

Annotated Interactions

No annotated interactions
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