IL-2 Signaling Pathway (Canis familiaris)

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DPhosphorylationCYCY -> NUInhibitionDDDAcetylationEndoplasmic reticulumMolecular associationSumoylationAccession Number: NetPath 14CY -> NUTranslocationDENNucleusNucleusMethylationGOCY -> NUMTEnzyme complexGlycosylationERProteolytic cleavageAutophosphorylationDeubiquitinationDUbiquitinationDesumoylationNUGolgi apparatusCY -> NUMT(Protein-protein interaction)CY -> NUDCY -> NUDNUPMControlDLigandDDeacetylationMolecule in the pathwayDProteins in a complex interactionCY -> PMReceptorDephosphorylationActivationPalmitolyationMitochondrionReactions through unknown mechanisms/moleculesCytoplasmDemethylationExtracellularRecruitmentCY -> NUCY -> NUDPhosphorylationPM -> CYEndosomeGene SymbolPlasma membraneECSTAT5APIK3R2PTPN11SHBPTK2BYBX1ICAM1AKT1CD53IL2RAMAPK9YBX1SOS1JAK2AKT1MKNK1FYNRELAGRB2ETS1LYNIL2BCL2RELANFKB1NR3C1PIK3CBLCKNFKB1SYKMAPK3PTPN6MAPK3IRS2GAB2EIF3BITM2BAKT1IFNA1IL2VAV1MAPK8IL2TERTSOCS3IL2RGSTAT5BSOCS1TERTCRKPIK3CDSTAMIL2CBLPLCB1PRKCZSTAT5BIL2RBSHC1STAT1MTOREIF4EIRS1GNB2L1STAT3RAF1MAPKAPK2ETS2MAPK1PIK3CGLOC480438PIK3R1STAT5AJAK3CREB1NMICRKLCRKRPS6KB1IL2HRASCISHCHUKMAP2K1MAP2K2MAPK1FOXO3ASTAM2JAK1MAPK14PIK3CARAF1


IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, you must cite the NetPath website until the pathway is published.


This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 94% conversion rate.

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89851view12:18, 6 October 2016Mkutmonremove GenMAPP notes
89847view12:16, 6 October 2016MkutmonModified description
73856view00:57, 26 February 2014MaintBotupdated schema
67366view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
40686view21:50, 1 March 2011MaintBotRemoved redundant pathway information and comments
35785view06:21, 13 February 2010MaintBotAdded description
32539view13:02, 17 August 2009MaintBotFixed text labels
31237view19:46, 13 August 2009MaintBotFixed text labels
30660view22:36, 29 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
BCL2GeneProduct403416 (Entrez Gene)
CD53GeneProduct610454 (Entrez Gene)
CHUKGeneProduct477796 (Entrez Gene)
CISHGeneProduct484757 (Entrez Gene)
CREB1GeneProduct607922 (Entrez Gene)
CRKLGeneProduct608125 (Entrez Gene)
EIF3BGeneProduct479766 (Entrez Gene)
EIF4EGeneProduct487870 (Entrez Gene)
ETS1GeneProduct489287 (Entrez Gene)
ETS2GeneProduct487761 (Entrez Gene)
FYNGeneProduct475032 (Entrez Gene)
GAB2GeneProduct485167 (Entrez Gene)
GNB2L1GeneProduct480818 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
HRASGeneProduct403735 (Entrez Gene)
ICAM1GeneProduct403975 (Entrez Gene)
IL2GeneProduct403989 (Entrez Gene)
IL2RAGeneProduct403870 (Entrez Gene)
IL2RBGeneProduct403439 (Entrez Gene)
IL2RGGeneProduct403851 (Entrez Gene)
IRS1GeneProduct486148 (Entrez Gene)
IRS2GeneProduct485548 (Entrez Gene)
ITM2BGeneProduct476916 (Entrez Gene)
JAK1GeneProduct442952 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
JAK3GeneProduct610004 (Entrez Gene)
LCKGeneProduct478151 (Entrez Gene)
LOC480438GeneProduct480438 (Entrez Gene)
LYNGeneProduct477886 (Entrez Gene)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MAPKAPK2GeneProduct490263 (Entrez Gene)
MKNK1GeneProduct482509 (Entrez Gene)
MTORGeneProduct478232 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
NMIGeneProduct476146 (Entrez Gene)
NR3C1GeneProduct478047 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PLCB1GeneProduct485773 (Entrez Gene)
PRKCZGeneProduct479577 (Entrez Gene)
PTK2BGeneProduct486102 (Entrez Gene)
PTPN11GeneProduct477488 (Entrez Gene)
PTPN6GeneProduct486717 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RELAGeneProduct483729 (Entrez Gene)
RPS6KB1GeneProduct480580 (Entrez Gene)
SHBGeneProduct481619 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
SOCS1GeneProduct490006 (Entrez Gene)
SOCS3GeneProduct442949 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
STAM2GeneProduct476150 (Entrez Gene)
STAMGeneProduct477990 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
STAT3GeneProduct490967 (Entrez Gene)
STAT5AGeneProduct490968 (Entrez Gene)
STAT5BGeneProduct490969 (Entrez Gene)
SYKGeneProduct484196 (Entrez Gene)
TERTGeneProduct403412 (Entrez Gene)
VAV1GeneProduct485016 (Entrez Gene)
YBX1GeneProduct479011 (Entrez Gene)

Annotated Interactions

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