Eicosanoid Synthesis (Canis familiaris)

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112-Hydroperoxy Eicosatetraenoic AcidProstaglandin E2Cell Membrane15-Hydroperoxy Eicosatetraenoic Acid6-Keto-Prostaglandin F2-alphaThromboxane A315-HETEProstaglandin H2PTGESPTGES25-HETEPeroxidase?LTC4SPTGS2ALOX15BPTGDSPeroxidase?5-HPETELeukotriene A4Thromboxane A2PTGS1Leukotriene E4Leukotriene B4ALOX15Prostaglandin I2Arachidonic acid12-HETEALOX12ALOX15Prostaglandin F2aPNPLA8DPEP1PGE2 9-ketoreducPeroxidase?PLA2G6ALOX5Leukotriene C4PLA2G6ALOX5APGGT1PTGISPGD2 11-ketoreducALOX5Prostaglandin D2PLA2G2AThromboxane B2TBXAS1LTA4HALOX5APLeukotriene D4


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 70% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''''; , PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106031view11:55, 16 August 2019MaintBotHMDB identifier normalization
89461view13:12, 15 September 2016Mkutmonremove space in ontology term id
71490view19:19, 17 October 2013MaintBotAutomated update of data sources
68599view23:25, 5 July 2013MaintBotUpdated to 2013 gpml schema
67182view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62729view03:19, 2 May 2013MaintBotUpdated UniProt data source
40758view21:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35480view12:15, 12 February 2010Thomasadded literature
35475view12:13, 12 February 2010ThomasModified description
34030view18:48, 9 December 2009MaintBotAutomatic update of empty xrefs
31722view11:55, 14 August 2009MaintBotFixed group labels
30659view22:36, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB0001193 (HMDB)
ALOX12GeneProduct479476 (Entrez Gene)
ALOX15GeneProduct489458 (Entrez Gene)
ALOX15BGeneProduct489485 (Entrez Gene)
ALOX5GeneProduct477753 (Entrez Gene)
ALOX5APGeneProduct477323 (Entrez Gene)
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
DPEP1GeneProduct479611 (Entrez Gene)
GGT1GeneProduct486400 (Entrez Gene)
LTA4HGeneProduct482611 (Entrez Gene)
LTC4SGeneProduct607316 (Entrez Gene)
Leukotriene A4MetaboliteHMDB0001337 (HMDB)
Leukotriene B4MetaboliteHMDB0001085 (HMDB)
Leukotriene C4MetaboliteHMDB0001198 (HMDB)
Leukotriene D4MetaboliteHMDB0003080 (HMDB)
Leukotriene E4MetaboliteHMDB0002200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct
PLA2G6GeneProduct481256 (Entrez Gene)
PNPLA8GeneProduct475880 (Entrez Gene)
PTGDSGeneProduct403740 (Entrez Gene)
PTGES2GeneProduct609101 (Entrez Gene)
PTGESGeneProduct480698 (Entrez Gene)
PTGISGeneProduct485919 (Entrez Gene)
PTGS1GeneProduct403544 (Entrez Gene)
PTGS2GeneProduct442942 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB0001403 (HMDB)
Prostaglandin F2aMetaboliteHMDB0001139 (HMDB)
Prostaglandin H2MetaboliteHMDB0001381 (HMDB)
Prostaglandin I2MetaboliteHMDB0001335 (HMDB)
TBXAS1GeneProduct482771 (Entrez Gene)
Thromboxane A2MetaboliteHMDB0001452 (HMDB)
Thromboxane B2MetaboliteHMDB0003252 (HMDB)

Annotated Interactions

No annotated interactions
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