Apoptosis Modulation by HSP70 (Bos taurus)

From WikiPathways

Jump to: navigation, search
1-8MitochondrionCELL SURVIVALProteasomeApoptosomeSTRESSDegradation of proteinsDegradation ofIk alpha(activation of NFkB)NFKB1CASP3CASP9TNFRSF1ANF-kB PathwayFADDMAPK10BID2CASP7AIFM1HSPA1AHSPA1AFADDRIPK1CYCSFASLGCASP2HSPA1ACASP8FASAPAF1CASP6CASP8ApoptosisMAP3K1CYCSTNF-alpha


Description

This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP384(67054) with a 84.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.''; Oncogene, 2003 PubMed Europe PMC Scholia
  2. Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  3. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  4. Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
  5. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.''; FEBS Lett, 1998 PubMed Europe PMC Scholia
  6. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  7. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.''; EMBO J, 1998 PubMed Europe PMC Scholia
  8. Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.''; FASEB J, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
98546view20:52, 14 September 2018KhanspersModified description
98539view20:49, 14 September 2018Khanspersremoved GenMAPP comments
98538view20:49, 14 September 2018KhanspersModified description
98537view20:49, 14 September 2018KhanspersModified description
80857view15:28, 30 June 2015Mkutmonhomology conversion
72060view17:22, 24 October 2013Mkutmonupdated annotation for APAF1
72024view12:47, 24 October 2013Mkutmonfixed unconnected lines
67052view10:00, 26 June 2013Christine ChichesterOntology Term : 'apoptotic cell death pathway' added !
63306view20:54, 9 May 2013MaintBotUpdated to 2013 gpml schema
62054view08:38, 24 April 2013Andra
40607view19:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
33844view00:33, 9 December 2009MaintBotAutomatic update of empty xrefs
32532view13:00, 17 August 2009MaintBotFixed text labels
32219view12:45, 15 August 2009MaintBotFixed text labels
31715view11:53, 14 August 2009MaintBotFixed group labels
31230view19:44, 13 August 2009MaintBotFixed text labels
30651view22:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AIFM1GeneProductENSBTAG00000006838 (Ensembl)
  • Apoptosis Inducing Factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9131
APAF1GeneProductENSBTAG00000021661 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:317
ApoptosisPathwayWP254 (WikiPathways)
BID2GeneProductENSBTAG00000013988 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:637
CASP2GeneProductENSBTAG00000018159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:835
CASP3GeneProductENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:836
CASP6GeneProductENSBTAG00000012537 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:839
CASP7GeneProductENSBTAG00000006615 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:840
CASP8GeneProductENSBTAG00000015718 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:841
CASP9GeneProductENSBTAG00000002472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:842
CYCSGeneProductENSBTAG00000022613 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54205
FADDGeneProductENSBTAG00000018274 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8772
FASGeneProductENSBTAG00000010785 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:355
FASLGGeneProductENSBTAG00000032808 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117560
HSPA1AGeneProductHomologyConvert: Multiple homologues found: En:ENSBTAG00000025441;En:ENSBTAG00000025441;
MAP3K1GeneProductENSBTAG00000013790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
MAPK10GeneProductENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
NF-kB PathwayPathway
NFKB1GeneProductENSBTAG00000020270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
RIPK1GeneProductENSBTAG00000006378 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8737
TNF-alphaGeneProduct
TNFRSF1AGeneProductENSBTAG00000004211 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7132

Annotated Interactions

No annotated interactions
Personal tools