Oxidation by Cytochrome P450 (Bos taurus)

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1Cytochrome P450 genesCYP20A1SubstrateCYP4A11CYP27A1CYPCYB5BFe2+CYP3A4CYPCYPNADP+CYP19A1CYP4F11SubstrateSubstrateCYP4Z1CYB5ACYP7A1CYP4F22NAD+CYP4F3Substrateactivated O2CYP51A1CYP2C19CYP39A1CYP7B1CYP4A22CYB5R3CYP2G1PCYP2C18PORCYP2B6CYP4B1CYP2R1CYB5BCYP3A43CYB5ACYPCYP2U1CYP4X1CYP2W1CYP2F1CYB5R4Fe3+Fe3+O2CYP26B1CYP8B1CYP2E1Fe2+O2CYP24A1CYP46A1Fe2+NADPHCYP1B1CYP27C1CYP2A6CYP1A2CYP1A1CYP11B1CYP21A2CYP27B1CYP11A1CYB5BFe3+CYP4F2SubstrateCYP51A1CYP2C8CYP2A13CYP2S1Fe3+CYP3A5CYP2J2CYP11B2Fe2+CYP26A1CYB5R2CYP26C1NADHCYPCYB5ACYP17A1CYP2A7Substrate-OHMGC127055CYB5R1CYP4F3CYP4F12CYP4V2H2OCYP3A7CYP2C9


Description

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP43(79993) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Niesink, R.J.M, Vries, de, J., Hollinger, M.A.; ''Toxicology; Principles and Applications''; , 1996

History

View all...
CompareRevisionActionTimeUserComment
107055view14:14, 17 September 2019MaintBotChEBI identifier normalization
105991view11:51, 16 August 2019MaintBotHMDB identifier normalization
102463view05:50, 24 December 2018EgonwFixed a data source.
101941view06:26, 19 November 2018EgonwReplaced Wikipedia with Wikidata identifiers.
80775view15:25, 30 June 2015Mkutmonhomology conversion
73517view23:31, 29 January 2014KhanspersModified title
72372view09:55, 13 November 2013EgonwFixed the PubChem-compound database name.
71405view19:01, 17 October 2013MaintBotAutomated update of data sources
70162view00:26, 13 July 2013AlexanderPicoModified title
63345view22:21, 9 May 2013MaintBotUpdated to 2013 gpml schema
58812view23:18, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40519view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
33762view00:03, 9 December 2009MaintBotAutomatic update of empty xrefs
31710view11:52, 14 August 2009MaintBotFixed group labels
30646view22:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CYB5AGeneProductENSBTAG00000012012 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166347
CYB5BGeneProductENSBTAG00000002412 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103018
CYB5R1GeneProductENSBTAG00000019927 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159348
CYB5R2GeneProductENSBTAG00000016142 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166394
CYB5R3GeneProductENSBTAG00000016516 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100243
CYB5R4GeneProductENSBTAG00000013591 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065615
CYP11A1GeneProductENSBTAG00000006934 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140459
CYP11B1GeneProductENSBTAG00000004596 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160882
CYP11B2GeneProductENSBTAG00000004596 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179142
CYP17A1GeneProductENSBTAG00000014335 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148795
CYP19A1GeneProductENSBTAG00000014890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137869
CYP1A1GeneProductENSBTAG00000001021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP1B1GeneProductENSBTAG00000010531 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
CYP20A1GeneProductENSBTAG00000000851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119004
CYP21A2GeneProduct
CYP24A1GeneProductENSBTAG00000002765 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019186
CYP26A1GeneProductENSBTAG00000021118 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095596
CYP26B1GeneProductENSBTAG00000012212 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000003137
CYP26C1GeneProductENSBTAG00000039973 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187553
CYP27A1GeneProductENSBTAG00000013489 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135929
CYP27B1GeneProductENSBTAG00000016906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111012
CYP27C1GeneProductENSBTAG00000038275 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186684
CYP2A13GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197838
CYP2A6GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
CYP2A7GeneProductENSBTAG00000047815 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198077
CYP2B6GeneProductENSBTAG00000003871 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197408
CYP2C18GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108242
CYP2C19GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165841
CYP2C8GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138115
CYP2C9GeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138109
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649
CYP2F1GeneProductENSBTAG00000046805 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197446
CYP2G1PGeneProduct
CYP2J2GeneProductENSBTAG00000013693 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134716
CYP2R1GeneProductENSBTAG00000010419 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186104
CYP2S1GeneProductENSBTAG00000018240 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167600
CYP2U1GeneProductENSBTAG00000012972 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155016
CYP2W1GeneProductENSBTAG00000017701 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073067
CYP39A1GeneProductENSBTAG00000003632 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146233
CYP3A43GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000021461
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP3A5GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106258
CYP3A7GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160870
CYP46A1GeneProductENSBTAG00000035544 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000036530
CYP4A11GeneProductENSBTAG00000000229 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187048
CYP4A22GeneProductENSBTAG00000000229 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162365
CYP4B1GeneProductENSBTAG00000011976 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142973
CYP4F11GeneProductENSBTAG00000038549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171903
CYP4F12GeneProductENSBTAG00000038549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186204
CYP4F22GeneProductENSBTAG00000047933 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171954
CYP4F2GeneProductENSBTAG00000038549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186115
CYP4F3GeneProductENSBTAG00000038549 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186529
CYP4F3GeneProductENSBTAG00000048257 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186526
CYP4V2GeneProductENSBTAG00000021263 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145476
CYP4X1GeneProductENSBTAG00000015647 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186377
CYP4Z1GeneProduct
CYP51A1GeneProductENSBTAG00000001992 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630
CYP7A1GeneProductENSBTAG00000005287 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167910
CYP7B1GeneProductENSBTAG00000001299 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172817
CYP8B1GeneProductENSBTAG00000034106 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000180432
CYPGeneProductENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1559
Fe2+MetaboliteCHEBI:29033 (ChEBI)
Fe3+MetaboliteCHEBI:29034 (ChEBI)
H2OMetaboliteHMDB0002111 (HMDB)
MGC127055GeneProductENSBTAG00000026501 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100197
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
NADP+MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
O2MetaboliteHMDB0001377 (HMDB)
PORGeneProductENSBTAG00000017082 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127948
Substrate-OHQ542929 (Wikidata)
SubstrateQ12119506 (Wikidata)
activated O2Metabolite

Annotated Interactions

No annotated interactions
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