Nuclear Receptors (Bos taurus)

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1Oxysterols ReceptorNR5 SUPERFAMILYRetinoic Acid Receptor RXRSteroid Hormone ReceptorRetinoic Acid ReceptorNuclear receptor TLXOrphan NuclearReceptorEstrogen ReceptorGlucocorticoid ReceptorNR2 SUPERFAMILYVitamin D3 ReceptorNuclear Receptor RORCoup Transcription FactorNR4 SUPERFAMILYProgesterone ReceptorSteroidogenic ReceptorThyroid ReceptorOrphan Nuclear ReceptorAndrogen ReceptorNR3 SUPERFAMILYOrphan ReceptorHepatocyte Nuclear FactorPeroxisome ProliferatorActivated ReceptorNR0 SUPERFAMILYNR1 SUPERFAMILYOrphan ReceptorNR2F1PPARDRORCPPARANR0B1RXRBretinoicacidNR1D2progesteroneNR1H2NR5A2RXRGESR2PPARGNR2F2THRBNR2E1ESRRBESR1OxysterolsNR1H3RARAROR1VDRestrogenTHRAARNR1I2PGRNR4A1RORAESRRARARGNR2F6THRBRARBNR1I3NR2C2RXRAPPARGNR4A2d3 vitaminsGR-ARARGHNF4ANR5A1


Description

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia (wikipedia:Nuclear_receptor)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP170(71083) with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
80758view15:24, 30 June 2015Mkutmonhomology conversion
69983view21:21, 11 July 2013MaintBot
69982view21:21, 11 July 2013MaintBotupdated to 2013 schema
67528view11:21, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
63480view17:23, 10 May 2013MaintBotupdating gpml
40573view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
35773view00:12, 13 February 2010AlexanderPico
33811view00:21, 9 December 2009MaintBotAutomatic update of empty xrefs
31700view11:49, 14 August 2009MaintBotFixed group labels
30637view22:28, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ARGeneProductENSBTAG00000022255 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:367
ESR1GeneProductENSBTAG00000007159 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2099
ESR2GeneProductENSBTAG00000004498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2100
ESRRAGeneProductENSBTAG00000008645 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2101
ESRRBGeneProductENSBTAG00000012285 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2103
GR-AGeneProductENSBTAG00000019472 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2908
HNF4AGeneProductENSBTAG00000012116 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3172
NR0B1GeneProductENSBTAG00000015532 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:190
NR1D2GeneProductENSBTAG00000018024 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9975
NR1H2GeneProductENSBTAG00000003264 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7376
NR1H3GeneProductENSBTAG00000010681 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10062
NR1I2GeneProductENSBTAG00000019557 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8856
NR1I3GeneProductENSBTAG00000009215 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9970
NR2C2GeneProductENSBTAG00000013716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7182
NR2E1GeneProductENSBTAG00000013991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7101
NR2F1GeneProductENSBTAG00000017599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7025
NR2F2GeneProductENSBTAG00000018007 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7026
NR2F6GeneProductENSBTAG00000011136 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2063
NR4A1GeneProductENSBTAG00000000507 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3164
NR4A2GeneProductENSBTAG00000003650 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4929
NR5A1GeneProductENSBTAG00000009017 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2516
NR5A2GeneProductENSBTAG00000009265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2494
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PGRGeneProductENSBTAG00000024648 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5241
PPARAGeneProductENSBTAG00000008063 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5465
PPARDGeneProductENSBTAG00000017542 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5467
PPARGGeneProductENSBTAG00000001333 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5468
RARAGeneProductENSBTAG00000012500 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5914
RARBGeneProductENSBTAG00000011518 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5915
RARGGeneProductENSBTAG00000007592 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5916
ROR1GeneProductENSBTAG00000012312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4919
RORAGeneProductENSBTAG00000015904 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6095
RORCGeneProductENSBTAG00000017405 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6097
RXRAGeneProductENSBTAG00000017851 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
RXRBGeneProductENSBTAG00000000602 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6257
RXRGGeneProductENSBTAG00000016801 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6258
THRAGeneProductENSBTAG00000010745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7067
THRBGeneProductENSBTAG00000017802 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7068
VDRGeneProductENSBTAG00000016414 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7421
d3 vitaminsMetaboliteCHEBI:73558 (ChEBI)
estrogenMetaboliteCHEBI:50114 (ChEBI)
progesteroneMetaboliteCHEBI:17026 (ChEBI)
retinoic acidMetaboliteCHEBI:26536 (ChEBI)

Annotated Interactions

No annotated interactions
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